Replication timing
DNA replication timing data corroborate in silico human replication origin predictions
... the replication timing ratio t r at the 83 putative ...in replication timing ratio between the borders and the center of the 38 replication domains of length L 1 ...
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Replication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell lines.
... of replication domains presenting gradients of replication fork polarity, we establish (i) that the replication fork polarity and the compositional skew are proportional to each other, (ii) that the ...
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Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm
... Replication timing profiles have also been used to identify replica- tion domains along ...constant timing regions (CTRs) using algorithms designed to delimit regions of locally flat profile, such as ...
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Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.
... Principal Findings: Here we show that in young proliferating embryonic fibroblasts (MEFs) the Polycomb Repressive Complex 2 (PRC2) member EZH2 together with PRC1 members BMI1 and M33 are strongly expressed and localized ...
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Efficient, quick and easy-to-use DNA replication timing analysis with START-R suite
... DNA replication must be faithful and follow a well- defined spatiotemporal program closely linked to transcriptional activity, epigenomic marks, intranu- clear structures, mutation rate and cell fate determi- ...
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Low rate of replication fork progression lengthens the replication timing of a locus containing an early firing origin
... genome replication in eukaryotic cells and its correlation with gene activity has been ...of replication timing. To evaluate replication schedule accuracy, we detailed the replicational ...
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Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome.
... Constant Timing Regions One possible mechanism for explaining why an equal proportion of rightward and leftward moving forks replicate a CTR is that it does not contain origins and is passively replicated from an ...
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Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cells
... Replication timing analysis 10-20 millions of exponentially growing mammalian cells (with DMSO or aphidicolin) were incubated with 0.5mM BrdU (Abcam, #142567), protected from light, at 37°C for 90 minutes. ...
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Replication timing of 10 developmentally regulated genes in Physarum polycephalum
... of Physarumr this is deduced from the preferential hybridization of 32P-labelled cDNAs to the HL DNA after in vivo bromodeoxyuridine incorporation for the first 40min in S-phase. T=EcoR1[r] ...
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Replication landscape of the human genome
... with replication direction, suggesting that mutational asymmetry of the leading and lagging strands led to skew accumulation over evolutionary times 14 ...of replication (in germline cells) across N-shaped ...
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Cholcystite aigue : Quel timing et quelle voie d'abord pour la cholcystectomie
... Dans les dernières années, plusieurs essais randomisés et méta-analyses (tableau 1) ont été réalisées pour déterminer le timing pour réaliser la cholécystectomie. Elles tendent toutes à privilégier une ...
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The Optimal Timing of CEO Compensation
... optimal timing of compensation results from a tradeoff between the progressive accumulation of noise in the stock price process over time on the one hand, and pro- gressive learning by outside investors on the ...
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Developmental Timing of Mammalian Limb Diversification
... Here, we show how the Longshanks model can be used to address three key topics in vertebrate limb skeletal evo- lution: (1) the developmental timing of morphological variation, (2) the c[r] ...
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Timing of Intervention in Aortic Stenosis.
... This leads to the question of how best to as- sess risk among patients with aortic stenosis, formulate a follow-up plan, decide on the timing of intervention, and devise a management strat- egy. Given that there ...
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Actual share repurchases, timing and liquidity
... I. Timing and liquidity hypotheses A. Timing or price support The explanation most frequently put forward for stock repurchases is the information- signaling ...managerial timing ability on the Hong ...
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Solving the Telomere Replication Problem
... the replication fork through the telomeric tract is probably one of the riskiest processes that occurs during chromosome ...a replication fork encounters when approaching the telomeric chromatin, and we ...
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Topoisomerase 1 suppresses replication stress and genomic instability by preventing interference between replication and transcription.
... persistent replication defects 5, 6 and acts as a selective pressure to inactivate p53 7 ...of replication stress in precancerous cells is currently ...of replication fork stalling in mammalian ...
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Long-term care and births timing
... As such, this paper pertains to several branches of the literature. First of all, it complements the existing literature on LTC and family games. That literature already emphasized the crucial role played by the age of ...
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Micro replication by injection-compression molding
... / La version de cette publication peut être l’une des suivantes : la version prépublication de l’auteur, la version acceptée du manuscrit ou la version de l’éditeur. For the publisher’[r] ...
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Content replication in mobile wireless networks
... Conclusion and perspectives Conclusion With the advance in new wireless technology, mobile devices have been widely used in human daily life as a multi-functional equipment for entertainment and information purpose. ...
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