receptor signaling
Adenosine receptor signaling: a key to opening the blood–brain door
... ARs signaling initiates changes in cytoskeletal organization and cell ...junctions, signaling induced by A 1 and A 2A recep- tor agonists altered the expression level of tight junction proteins such as ...
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The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells
... transferrin receptor (TfR), showed that the complex and regulated trafficking of the protein depends on its cytosolic ...immune receptor signaling and modulation of inflammatory ...
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The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies
... 5-HT 6 receptor agonist, WAY181187 (Loiseau et al., 2008). Again, this contradicts the data of another study which showed a significant improvement of working memory in rats treated with EMD386088 or with the ...
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The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate
... T-cell receptor (TCR) αβ heterodimer on their cell surface that can recognize foreign or self-protein-derived peptides presented by the major histocompatibility complex (MHC) class-I or ...
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TRAIL receptor signaling and therapeutic option in bone tumors: the trap of the bone microenvironment.
... death receptor-induced apoptosis and abroga- tion of TRAIL resistance in vitro lead to in- creased tumor cell sensitivity to TRAIL and the concomitant inhibition of Ewing’s sarcoma growth ...death receptor ...
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Gene Structure, Expression, and 5-HT2B Receptor Signaling
... target receptor by acting at a site other than the native ligand-binding site ...specific signaling pathway, have been ...endogenous signaling through the 5-HT 2 ...
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Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex
... V2R expression and purification The optimized sequence of the human V2R was cloned into a pFastBac1 vector (Invitrogen) for insect cell expression. To facilitate expression and purification of the V2R construct used for ...
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Reciprocal Effects of Fibroblast Growth Factor Receptor Signaling on Dengue Virus Replication and Virion Production
... FGFR Signaling Pathway Among the HDFs identified in this kinome screen, knockdown of FGFR4 showed a robust reduction of viral ...FGFR signaling pathway, we selected this hit for further ...FGFR ...
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Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma.
... BCR signaling in MCL was recently investigated using a high-throughput phospho-proteomic technique which identified more than 300 tyrosine- phosphorylated proteins ...BCR signaling even in absence of anti- ...
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Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells
... TLR signaling has been extensively studied in macrophages/monocytes in the context of the cell membrane localized TLR4 [ 22 – 24 ...TBK1 signaling and production of type I IFNs, however, they showed an ...
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Prostaglandin EP2 receptor signaling protects human trabecular meshwork cells from apoptosis induced by ER stress through down-regulation of p53
... system where its neuronal activation promotes neuroprotective functions while microglial activation induces neuroinflammation [27]. In addition, EP2 receptor plays a pivotal role in tumorigenesis. In particular, ...
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A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation
... TCR-dependent signaling pathways upon antigen recogni- tion [ 19 ...TCR signaling leads to transient Erk activation and favors Th2/Treg differentiation, whereas stronger TCR signaling leads to ...
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Modulation of T cell antigen receptor signaling in CD8+ T lymphocytes following priming with homeostatic and inflammatory cytokines
... The percent of cytokine-primed and naïve 8.3-NOD CD8+ T cells which formed conjugates with the NRP-A7 peptide-loaded RMAS-Kd cells was divided by the percent ofthose cells which formed[r] ...
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Pre-B Cell Receptor Signaling Induces Immunoglobulin κ Locus Accessibility by Functional Redistribution of Enhancer-Mediated Chromatin Interactions
... interleukin-7 receptor (IL-7R) signals to drive proliferative expansion of IgH m + large pre-B cells ...Subsequently, signaling through the pre-BCR downstream adapter Slp65 (SH2-domain-containing leukocyte ...
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Targeting 5-HT 2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling after Myocardial Infarction
... Supplemental Figure 9: 5-HT 2B antagonism does not alter cardiac structure or function following. 19[r] ...
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Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling.
... BCR signaling pathway represents an attractive target in therapy for several types of B-cell lymphoma, and there is intensive search for surrogate markers that can serve as predictors of response and to understand ...
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Estrogen receptor signaling as a target for novel breast cancer therapeutics
... CXCR4 receptor may induce a “feed forward” loop, leading to phosphorylation of both ERs through Erk activation, a mechanism which could explain BC cell growth and Tam resistance ...
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Estrogen receptor signaling as a target for novel breast cancer therapeutics.: new targets in estradiol receptor-positive breast cancers
... 14 accelerated cell proliferation. IGF I and II are secreted in practically all epithelial cells, and the binding of IGFI to IGF-1R increases tumor growth and development. Furthermore IGF-1R and the insulin receptors ...
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The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling
... LUBAC, Signaling, Lymphoma, NF-κB INTRODUCTION The engagement of antigen receptors in B and T lymphocytes assembles a large signaling complex of CARMA1 (also called CARD11), BCL10, and MALT1 (the CBM ...
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Cellular defense processes regulated by pathogen-elicited receptor signaling
... TLR-4 signaling network, but how its individual pathway activities work together to determine cell death-versus-survival fate remains ...TLR-4 signaling network in determining its outputs, and sought to ...
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