Radionuclide therapy
Theranostic Approach for Metastatic Pigmented Melanoma Using ICF15002, a Multimodal Radiotracer for Both PET Imaging and Targeted Radionuclide Therapy
... INSERM, U1196, F-91405, Orsay, France Abstract PURPOSE: This work reports, in melanoma models, the theranostic potential of ICF15002 as a single fluorinated and iodinated melanin-targeting compound. METHODS: Studies were ...
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Introduction to Radiobiology of Targeted Radionuclide Therapy
... receptor radionuclide therapy (PRRT) started to be assessed in the 70–80s and led to the devel- opment of 90 Y-DOTATATE and 90 Y-DOTATOC that are currently used for the treatment of neuroendocrine ...the ...
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Multi-scale dosimetry for targeted radionuclide therapy optimisation
... defined, and the absorbed dose to the bladder, the bladder wall and the uterus is scored. The source spatial distribution in the LR–SS model coincided with the bladder voxels. For both high resolution models, the source ...
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Impact of Mouse Model on Pre-Clinical Dosimetry in Targeted Radionuclide Therapy
... Abstract Introduction: Small animal dosimetry serves as an important link in establishing a relationship between absorbed dose and biological effect during pre-clinical targeted radionuclide therapy. ...
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Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
... Conclusion The dimensions and 3D shape of early brain metastasis and their associated blood vessels were used to build an in silico replica. The model was designed to mimic targeting of VCAM-1, an endothelial marker of ...
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en fr Development of a new anti-cancer agent for targeted radionuclide therapy : ß- radiolabeled RAFT-RGD. Le RAFT-RGD radiomarqué avec un émetteur °- comme nouvel agent de radiothérapie interne vectorisée
... Il est très difficile de traiter toutes les séries lorsque les tumeurs ont le même volume car les tumeurs ne poussent pas de la même manière entre les séries malgré certaine[r] ...
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Radiopharmaceutical dosimetry in targeted radionuclide therapy
... The different steps of clinical dosimetry in this context includes the determination of the calibration factor of imaging systems, image acquisition and reconstruction, segmentation of[r] ...
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MSPT : Motion Simulator for Proton Therapy
... Proton Therapy Based on the dose prescribed by a physician and the volumes previously defined, a physicist or a dosimetrist will produce a treatment plan defining the gantry angles and the control files of the ...
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Photodynamic therapy of cancer: an update.
... Head and Neck Tumors PDT has been successfully employed to treat early carcinomas of the oral cavity, pharynx, and larynx, preserving normal tissue and vital functions of speech and swallowing. 180 Multiple institutions ...
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Formalizing the Cardiac Pacemaker Resynchronization Therapy
... In 2003 Tony Hoare suggested a verification grand challenge for computing research. In similar vein, a real ten year-old, sanitized pacemaker specification [ 3 ] was used by the Software Quality Research Laboratory at ...
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Hormonal therapy and depression: are we overlooking an important therapeutic alternative?: Hormonal therapy and depression
... first-line therapy by 69% of experts for first episodes of mild and moderate depression occurring at perimenopause, antidepressants being recommended as the second ...
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Personalising metformin therapy: a clinician's perspective
... Therefore, instead of prescribing metformin to every person with type 2 diabetes, a valuable alternative might be to select the more appropriate patients for this pharmacological approach. For a long time, the physician ...
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The mangrove pump: The tidal flushing of animal burrows in a tropical mangrove forest determined from radionuclide budgets
... Rn daughters, and 222 Rn activity is determined by dis- criminating the 222 Rn-daughter decays in energy-specific windows. The spatial distribution of 222 Rn in the creek was recorded by continuously sampling whilst ...
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Stochastic analysis of the effect of spatial variability of diffusion parameters on radionuclide transport in low permeability clay layer
... between 21 % smaller and 3 % larger in the heterogeneous model. The radionuclide activity flowing through the upper clay-aquifer is between 25 % smaller and 2.5 % larger. DISCUSSION A model with a heterogeneous ...
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Gene Therapy for ALS—A Perspective
... gene therapy open a new perspective to treat this disorder—particularly for the characterized genetic ...Gene therapy approaches, involving the delivery of antisense oligonucleotides into the central ...
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Image-guided therapy: evolution and breakthrough.
... particle therapy) exploits heavy protons and has the advantage over photons or lighter particles to penetrate deeply in the body while transferring almost all the energy at the end of their ...proton ...
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Gene therapy of primary T cell immunodeficiencies.
... Extending our present experience The results achieved to date have provided proof of concept for gene therapy of SCIDs and WAS. It will be critical to see whether the SIN vectors are indeed as safe as expected in ...
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Computer simulation of neutron capture therapy.
... However, the thermal neutron flux and boron capture dose rate decrease faster than the fast neutron dose rate, resulting in a decrease in beam effectiveness... These material[r] ...
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Computer simulation of neutron capture therapy
... However, the thermal neutron flux and boron capture dose rate decrease faster than the fast neutron dose rate, resulting in a decrease in beam effectiveness... These material[r] ...
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Accelerator-based boron neutron capture therapy
... For the purpose of this thesis, the term Accelerator-Based BNCT (AB-BNCT) will be used to describe the production of neutrons through charged particle induced react[r] ...
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