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pyruvate dehydrogenase

E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity

E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity

... | pyruvate | muscle | endurance T he pyruvate dehydrogenase (PDH) complex (PDC) is a mi- tochondrial multimeric complex that catalyzes the oxidative decarboxylation of pyruvate into acetyl-CoA ...

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Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

... Jerry W. Shay 4 , Xavier Coumoul 1,2 , Robert Barouki 1,2 , Chantal Benelli 1,2 , Laurence Huc 5,6 & Sylvie Bortoli 1,2 Resveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-inflammatory ...

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E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis

E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis

... Controls Pyruvate Metabolism in Keratinocytes Through Transcrip- tional Regulation of the E2 Subunit of the Pyruvate Dehydrogenase Complex ...mitochondrial pyruvate dehydrogenase (PDH) ...

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Increased mtPDH activity through antisense inhibition of mitochondrial pyruvate dehydrogenase kinase enhances inflorescence initiation, and inflorescence growth and harvest index at elevated CO2 in Arabidopsis thaliana

Increased mtPDH activity through antisense inhibition of mitochondrial pyruvate dehydrogenase kinase enhances inflorescence initiation, and inflorescence growth and harvest index at elevated CO2 in Arabidopsis thaliana

... ( Baud et al., 2008 ) owing to the amount of tissue required, and 1.5 mL of extraction buffer. After vortexing and the initial 20 min centrifugation step, the resulting supernatant was brownish and turbid, unlike the ...

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Pyruvate dehydrogenase deficiency presenting as intermittent isolated acute ataxia

Pyruvate dehydrogenase deficiency presenting as intermittent isolated acute ataxia

... Case reports Patient 1, born at term to unrelated parents, had a normal neonatal period and early development. He walked without support at 12 months. At 18 months, he was admitted for acute ataxia during an upper ...

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Seed-Specific Overexpression of the Pyruvate Transporter BASS2 Increases Oil Content in Arabidopsis Seeds

Seed-Specific Overexpression of the Pyruvate Transporter BASS2 Increases Oil Content in Arabidopsis Seeds

... provide pyruvate through glycolytic reactions in the ...to pyruvate by cytosolic pyruvate kinase ( Andre et ...into pyruvate by plastidial pyruvate kinase. Plastidial pyruvate ...

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PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis

PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis

... represses pyruvate oxidation via inhibition of pyruvate dehydrogenase (PDH; a complex of three enzymes that converts pyruvate into acetyl-CoA) and, hence, influences the switch from glucose ...

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Pyruvate formate-lyase and a novel route of eukaryotic ATP-synthesis in Chlamydomonas mitochondria

Pyruvate formate-lyase and a novel route of eukaryotic ATP-synthesis in Chlamydomonas mitochondria

... Lys 1216 –His 1303 ). The PFO sequence inferred from the gene model exhibits four highly conserved PFO motifs including two [4Fe-4S] ferre- doxins, and the iron-sulfur binding region signature (Prosite PS00198) FIGURE 6. ...

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Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase

Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase

... the pyruvate branch point, the parental cells converted 51% of the pyruvate pool into acetyl-CoA via the pyruvate dehydrogenase, 48% to lactate via lactate dehydrogenase and the ...

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Glycolytic pyruvate kinase moonlighting activities in DNA replication initiation and elongation

Glycolytic pyruvate kinase moonlighting activities in DNA replication initiation and elongation

... the pyruvate dehydrogenase (PdhC) and related enzymes were shown to inhibit replication initiation and/or bind to the origin region or to replication enzymes (the helicase DnaC and the primase DnaG) (Laffan ...

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Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase.

Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase.

... Background Pyruvate dehydrogenase complex (PDHc) deficiency most often occurs as an isolated enzyme defect caused by muta- tions in X-linked PDHA1 [MIM 300502] and associates with a spectrum of clinical ...

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Étude de l'implication des navettes du pyruvate découlant du métabolisme mitochondrial du glucose dans la régulation de la sécrétion d'insuline par les cellules bêta pancréatiques

Étude de l'implication des navettes du pyruvate découlant du métabolisme mitochondrial du glucose dans la régulation de la sécrétion d'insuline par les cellules bêta pancréatiques

... Discussion Using the siRNA technology in transfected cells, we observed that reduced IDHc expression results in stimulation of GIIS without affecting basal secretion, KCl-induced insulin release, the total cellular ...

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Biotransformation of CL-20 by a dehydrogenase enzyme from Clostridium sp. EDB2

Biotransformation of CL-20 by a dehydrogenase enzyme from Clostridium sp. EDB2

... a dehydrogenase class of enzyme from anaerobic bacterial strain EDB2 biotransformed CL-20 via three different path- ways which were previously not known in biological sys- ...

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Mechanism of control of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase by threonine

Mechanism of control of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase by threonine

... 100 m M L -malate-KOH, pH 8.0. Production of aspartate semialdehyde was initiated by the addition of 30 ␮g of pure A. thaliana monofunc- tional AK (overproduced and purified in our laboratory) 2 and 70 ␮g of pure A. ...

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The Plant Short-Chain Dehydrogenase (SDR) superfamily:genome-wide inventory and diversification patterns

The Plant Short-Chain Dehydrogenase (SDR) superfamily:genome-wide inventory and diversification patterns

... xanthoxin dehydrogenase (abscissic acid biosynthesis) [39,40], rice diterpenoid momilactone synthase A [41], mint (Mintha sativa) isopiperitenol dehydrogenase [42], Forsythia intermedia secoisolariciresinol ...

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Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population

Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population

... Pyruvate kinase (PK) catalyzes the last rate-limiting step of glycolysis. There are two genes in humans that code for pyruvate kinases, the liver/erythrocyte-specific enzyme (PKLR) and the muscle specific ...

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Thermal activation of 'allosteric- like' large-scale motions in a eukaryotic Lactate Dehydrogenase

Thermal activation of 'allosteric- like' large-scale motions in a eukaryotic Lactate Dehydrogenase

... fully applied to systems that exhibit long-range signaling modes via domain displacement, as in the case of the NHERF1 25 , Taq polymerase 23 , and Phosphoglycerate Kinase 26 , as well as to Alcohol Dehydrogenase, ...

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Functional characterization of SlscADH1, a fruit-ripening associated short-chain alcohol dehydrogenase of tomato

Functional characterization of SlscADH1, a fruit-ripening associated short-chain alcohol dehydrogenase of tomato

... González-Guzmán M, Apostolova N, Bellés JM, Barrero JM, Piqueras P, Ponce MR, et al. The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde. Plant Cell ...

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Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

... Pyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in all organisms, with tight regulation by multiple metabolites. Yet the allosteric ...

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"CODE PK", vers un registre national des patients déficitaires en pyruvate kinase intraérythrocytaire. À propos des 60 premiers patients inclus

"CODE PK", vers un registre national des patients déficitaires en pyruvate kinase intraérythrocytaire. À propos des 60 premiers patients inclus

... PARTIE 1 : Déficit en pyruvate kinase intraérythrocytaire, notions fondamentales La fonction première de l’hématie est le transport d’oxygène vers les tissus. Pendant les 120 jours au cours desquels elle circule ...

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