Protein-Ligand interactions
Development of chemogenomic approaches for prediction of protein - ligand interactions
... with protein information, and the ulti- mate goal is to identify all possible interactions between ligands and proteins of the ...the protein-ligand space makes any systematic experimental ...
160
Rapid and easy development of versatile tools to study protein/ligand interactions
... hybrid protein BlaP CHBD to calculate the relative equi- librium association constant (K r ) of CHBD to insoluble chitin and to quantify the amount of bound protein by measuring the free and immobilised ...
9
A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR
... molecules solved in complex with EthR show a large diversity of chemical structures that were.. split up into several chemical clusters3[r] ...
43
en fr Study of the effects of glycation on protein-ligand interactions in diabetes and atherosclerosis : the link between albumin and liraglutide and between apolipoprotein A1 and its binding partners Etude des effets de la glycation sur les interactions protéine-ligand dans le cadre du diabète et de l’athérosclérose : la liaison entre l’albumine et le liraglutide et entre l’apolipoprotéine A1 et ses partenaires de liaison
... 28 sont les plus affectées. La glycation touche également de nombreuses autres protéines du sang (globulines, complément C3…). Ainsi, la glycation de l’apolipoprotéine A1, constituant majoritaire des lipoprotéines de ...
236
Accurate Representation of Protein-Ligand Structural Diversity in the Protein Data Bank (PDB)
... Keywords: protein-ligand complexes; dataset; clustering; structural alignment; refinement ...Introduction Protein structures are the support of essential biological ...the Protein Data Bank ...
18
Solid-State 17O NMR Spectroscopy of Large Protein-Ligand Complexes
... for protein–ligand complexes as large as 300 kDa per ligand with 90 % 17 O enrichment and a data-acquisition time of 48 ...probing protein–ligand ...
5
MoMA-LigPath: A web server to simulate protein-ligand unbinding
... Protein-ligand interactions taking place far away from the active site, during ligand binding or release, may determine molecular specificity and ...these interactions with experimental ...
7
Sliding tethered ligands add topological interactions to the toolbox of ligand-receptor design
... D D Figure 8 | Net attractive forces induced by STLs mediated specific interactions. Force profiles obtained on approach (circles) and on separation (all other symbols) after subtraction of DLVO contribution on the ...
9
Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology
... targeting protein-protein interactions (PPIs) that predominantly rely on designing scaffolds for accurately mimicking protein secondary structure, for targeting ...
22
study of the multivalent carbohydrate/protein interactions on silicon biosensors
... Mots-clés: interactions glycane-protéine; biopuce à glycanes; silicium cristallin; silicium amorphe carboné; exaltation plasmonique de la fluorescence; spectroscopie infrarouge quantitative; chimie ...
164
Dual-color fluorescence lifetime correlation spectroscopy to quantify protein-protein interactions in live cell.
... A way of getting rid of the bleed-through is the so-called switching method or pulsed interleaved excitation (Müller et al., 2005; Thews et al., 2005; Takahashi et al., 2008). In this method, two alternating laser beams ...
18
Non-classical ligand-independent regulation of Go protein by an orphan Class C GPCR
... Here we addressed the role of scaffolding and signaling of GPR158. We show that RGS7 interacts in the proximal part of the C-terminal intracellular domain, while Gao interacts downstream of this site with two of the ...
43
Characterization of a novel class of anti-HCV agents targeting protein-protein interactions
... pairwise interactions between HCV proteins In a previous work with an aim of identifying new functional HCV protein interactions (232), all possible interaction combinations between pairs of HCV ...
123
From Protein Corona to Colloidal Self-Assembly: The Importance of Protein Size in Protein-Nanoparticle Interactions
... Size-Dependent Protein–Nanoparticle Interactions in Citrate-Stabilized Gold Nanoparticles: The Emergence of the Protein ...Aude. Protein Corona Composition of Silica Nanoparticles in Complex ...
42
LeView: automatic and interactive generation of 2D diagrams for biomacromolecule/ligand interactions.
... water-mediated interactions involving the ligand or ion, with up to four bridging water molecules, are not dis- played by default but can be added to the diagram through the ...i.e. ligand atoms ...
8
ClpX interactions with ClpP, SspB, protein substrate and nucleotide
... protein, these data suggest that ATP binding leads to structural changes in the central pore. In principle, changes in tryptophan fluorescence could also reflect assembly of subunits into hexamers. However, our ...
167
Drug/protein interactions studied by time-resolved fluorescence spectroscopy
... transport protein in the human ...the protein microenvironment playing a significant role in the conformational relaxation of FBP, which is more restricted in the case of the (R)- ...
5
Generation of a versatile BiFC ORFeome library for analyzing protein-protein interactions in live Drosophila
... visualize interactions in the overlapping expression domain of the two protein ...bait protein (for example Hox-Gal4 ...Gal4 protein in the overlapping expression domain of the two enhancers, ...
25
Structural basis for Fe–S cluster Assembly and tRNA thiolation mediated by IscS protein–protein interactions
... other protein-protein combinations with IscS, including IscU-CyaY (Figure S6B) [13,14], IscU-IscX (Figure S6C), TusA-IscX (Figure S6D), and TusA-CyaY (Figure ...
19
en fr Computational approaches to molecular recognition : from host-guest to protein-ligand binding Approches computationnelles de la reconnaissance moleculaire : l'analyse de la liaison hôte-invite et protéine-ligand
... R E S U M É l e c o n t e x t e La reconnaissance moléculaire représente un événement central dans de nombreux pro- cessus chimiques et biologiques pertinents. Dans le domaine biologique, un exemple de re- connaissance ...
105