Protease-activated receptors
Protease-Activated Receptors in the Intestine: Focus on Inflammation and Cancer
... France Protease-activated receptors (PARs) belong to the G protein-coupled receptor (GPCR) ...physiologically activated after proteolytic cleavage of their N-terminal domain by ...these ...
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Increased mucosal thrombin is associated with Crohn's disease and causes inflammatory damage through Protease-Activated Receptors activation
... We then investigated whether the proinflammatory effects of thrombin administered into the colon of mice were dependent on the activation of PAR1, the first identified thrombin receptor. 27 , 28 We first used a ...
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Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model
... Abstract Human metapneumovirus (hMPV) infection causes acute respiratory tract infections (RTI) which can result in hospitalization of both children and adults. To date, no antiviral or vaccine is available for this ...
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Protease-activated receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation
... Abstract Toxoplasma gondii is a widespread intracellular parasite, which naturally enters the organism via the oral route and cross the intestinal barrier to disseminate. In addition to neuronal and ocular pathologies, ...
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Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells.
... 2005). Protease-activated receptors (PARs) are a family of 4 different receptors that are activated by various proteases (Hollenberg and Compton, 2002; Macfarlane et ...the ...
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Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.
... via protease- activated receptors ...of activated fibrogenic cells (64% and 79% decrease in PAR-1 +/- and PAR-1 -/- mice, respectively, ...
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Protease Activity Assay in Fly Intestines
... *For correspondence: gallet@unice.fr [Abstract] The intestine is a central organ required for the digestion of food, the absorption of nutrients and for fighting against aggressors ingested along with the food. ...
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Rat hepatocytes express functional P2X receptors.: Rat hepatocytes express functional P2X receptors
... P2 receptors. There are several types of P2 receptors: ligand-gated cationic channels or P2X receptors, and G protein-coupled P2Y ...P2Y receptors are expressed by all cell types [1, 6, 8-9] ...
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The proline-rich motif of the proDer p 3 allergen propeptide is crucial for protease-protease interaction.
... Spontaneous hydrolysis of all proline mutants occurred upon desalting. Mass spectrometry permitted to independently monitor the different truncated forms during the activation process of proDer p 3 by Der p 1. For the ...
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Keratinolytic protease genes in Bacillus pumilus strain C4 - Enhancement of extracellular protease production and molecular screening
... Analysis of the protein fraction related to protease activity produced by Bacillus pumilus C4 through nLC-ESIMS/MS followed by Mascot database search confirmed that the two genes ker1 an[r] ...
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ADAM28: Another ambivalent protease in cancer
... ambivalent protease in cancer? ADAM28 is overexpressed by carcinoma cells in multiple cancer types: breast cancer [ 9 , 12 , 13 ], renal cell carcinoma [ 58 ], non-small cell lung carcinoma (NSCLC) [ 59 , 60 ], ...
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General molecular biology and architecture of nuclear receptors.: Transcriptional regulation by nuclear receptors
... Heterodimers can adopt various polarities when bound to different REs, and RXR can be positioned either upstream or downstream of the heterodimer partner. This relative orientation and its impact on the transcriptional ...
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Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease
... rhomboid protease YqgP interacts with the membrane-bound ATP-dependent proces- sive metalloprotease FtsH and cleaves MgtE, the major high- affinity magnesium transporter in ...sic protease activity, YqgP ...
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Protein crystallogenesis of the arrowhead protease inhibitor-A
... The catalytic triad is part of an extensive hydrogen bonding network. It spans the active site cleft, with Ser195 on one side and Asp102 and His57 on the other (Figure 3). Generally, hydrogen bonds are shown between the ...
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Chemokine receptors in allergic diseases
... Chemokine receptors in food allergy IgE-mediated food allergies induce various symptoms and can affect the skin, the intestine, and the lungs. They are trig- gered by food allergens, which are usually harmless for ...
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A long-lasting calcium-activated nonselective cationic current is generated by synaptic stimulation or exogenous activation of group I metabotropic glutamate receptors in CA1 pyramidal neurons.
... CAN is modulated by divalent cations, and (3) a high-frequency stimulation (HFS) synaptically generates a slow inward current through mGluRs, once glutamate and GABA ionotropic receptors have been blocked. This ...
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AMP-Activated Protein Kinase Signalling
... 22. Didier, S.; Sauve, F.; Domise, M.; Buee, L.; Marinangeli, C.; Vingtdeux, V. AMP-activated protein kinase controls immediate early genes expression following synaptic activation through the pka/creb pathway. ...
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Electrophysiology of ionotropic GABA receptors
... Membrane resistivity (ρ) is equal to the transmembrane potential (ΔE) divided by the intensity (I) of the current passing through a unit of membrane surface: ρ = ΔE × S/I (where S is the area of the membrane domain). The ...
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Death receptors as targets in cancer
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Protease inhibition as new therapeutic strategy for GI diseases
... Both trypsin and tryptase have been shown to activate PAR 2 . 85 In all animal studies investigating by which mechanisms tryptase, trypsin or IBS patient biopsy supernatants were causing increased permeability, neuron ...
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