protease-activated receptor
Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer
... CA. Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary ...proteinase-activated receptor-1 signaling affords protection from ...
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Dexamethasone prevents visceral hyperalgesia but not colonic permeability increase induced by luminal protease-activated receptor-2 agonist in rats
... Version postprint Comment citer ce document : Roka, R., Ait-Belgnaoui, A., Cartier, C., Garcia Villar, R., FIORAMONTI, J., Eutamene, H., Bueno, L. (2007). Dexamethasone prevents visceral hyperalgesia but not colonic ...
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Activation of protease-activated receptor-2 increases in vitro jejunal muscle responses to cholinergic and tachykinergic stimulation in rats
... Version postprint Comment citer ce document : Chambert, N., Garcia Villar, R., Cenac, N., Guiard, B., Fioramonti, J., Bueno, L. (2001). Activation of protease-activated receptor-2 increases in vitro ...
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Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease-activated receptor-2 and cyclooxygenase-2
... of protease-activated receptor-2 (PAR-2) and a subse- quent increase in COX-2 expression, a finding adding further importance to the role of COX-2 as an important actor for myogenesis in situation of ...
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Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells.
... RESULTS Protease-activated receptor type 1 (PAR1) and G αi1 protein fused to energy acceptor and donor ...PAR1-YFP activated signaling pathways in similar way than the wild- type ...
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Protease-activated receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation
... the Protease- Activated Receptor (PAR) family ...are activated through proteolytic cleavage of their extracellular N-terminal domain, thereby creating a new N-terminal fragment that serves as ...
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Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism
... The recent development of human colon organoid cultures allows pharmacological testing of compounds in three-dimensional (3D) primary cell cultures in com- plex human epithelia (Sato et al., 2011; Crespo et al., 2017). ...
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Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model
... and snap frozen. RNA was extracted and furin transcript levels were determined using RT-PCR. Significant differences in furin transcript levels were observed between treated and untreated mice based on a Student T-test ...
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Rat protease-activated receptor–1 (rPAR1) expression and characterization in Sf9 cells
... this receptor and coupling to Gα s yields an increase in intracellular calcium through the release of Ca 2+ from intracellular stores ...is activated secondary to intracellular Ca 2+ release from ...
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Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.
... Abstract Thrombin inhibition protects against liver fibrosis. However, it is not known whether thrombin profibrogenic effect is due to effects on blood coagulation or to signaling via protease- activated ...
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Intracellular trafficking of protease : Activated Receptor 2 (PAR2) by members of sorting nexins family
... upon protease activation is a challenge especially in systems where more than one receptor is ...for protease-stimulated activation of the ...
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Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
... Mice monocolonized with P. aeruginosa PA14 WT had a higher presence of bacteria within the mucus layer, suggesting that bacterial elastase is also used for mucus invasion. This encroachment toward the mucosal surface was ...
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Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage.: Dual effects of ALK on apoptosis : a new dependence receptor
... ALK receptor kinase is not tyrosine phosphorylated, and actively enhances or triggers apoptosis, whereas kinase activation, induced by a ligand or constitutive as in NPM-ALK, decreases ...ALK receptor ...
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Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens <em>in vitro-</em> and <em>in vivo-</em>induced murine osteoarthritis
... coupled receptor 40 (GPR40) are proposed as attractive therapeutic targets to counteract inflammation and cartilage degradation observed in ...acid receptor (FFAR), G-protein coupled receptor 40, ...
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Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism
... We previously demonstrated that PPARs and were expressed constitutively in rat synovial fibroblasts and that PPAR agonists inhibited TNF and IL-1 gene expression through interaction with the NF- B signaling pathway (28). ...
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A role for peroxisome proliferator-activated receptor gamma in resveratrol-induced colon cancer cell apoptosis.
... Proliferator-Activated Receptor gamma) in colon cancer cells, we sought to determine the implication of this nuclear transcription factor in resveratrol-induced ...
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Colonic luminal proteases activate colonocyte proteinase-activated receptor-2 and regulate paracellular permeability in mice
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential
... Abstract In the era of precision medicine, treatments that target specific modifiable characteristics of high‑risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. ...
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Tachykinin NK1 receptors are involved in proteinase-activated receptor (PAR)-2-mediated colonic inflammation in mice
... Version preprint Comment citer ce document : Cenac, N., Guiard, B., Garcia Villar, R., Fioramonti, J., Bueno, L. (2001). Tachykinin NK1 receptors are involved in proteinase-activated receptor ...
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Tachykinin NK1 receptors are involved in proteinase-activated receptor-2-mediated visceral hyperalgesia in rats
... Bruno Guiard, Nicolas Cenac, Rafael Garcia Villar, Anne-Marie Coelho, Jean Fioramonti, Lionel Bueno. To cite this version:[r] ...
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