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protease-activated receptor-1

Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.

Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.

... Material and Methods Animals PAR-1-deficient mice were established by Connolly et al (9) and were studied in the C57BL/6 background. We used only male animals, aged 10-12 weeks, and weighing 31.0 ± 2.5 g at the ...

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Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells.

Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells.

... Real-time analysis of PAR1-G αi1 association and desensitization. Kinetic analysis showed that thrombin-induced BRET increase between G αi1 -Rluc and PAR1-YFP occurred rapidly (t1/2 = 4.3 ± 0.6 s, n=13) (Fig. 5A). This ...

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Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model

Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model

... ubiquitous receptor present in platelets, endothelial and epithelial cells, neurons, fibroblasts, smooth muscle cells, leukocytes and tumor cell lines ...a receptor involved in many physiological processes ...

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Rat protease-activated receptor–1 (rPAR1) expression and characterization in Sf9 cells

Rat protease-activated receptor–1 (rPAR1) expression and characterization in Sf9 cells

... this receptor and coupling to Gα s yields an increase in intracellular calcium through the release of Ca 2+ from intracellular stores ...is activated secondary to intracellular Ca 2+ release from ...

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Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism

Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism

... In that setting, thrombin appears as a most impor- tant candidate, since IBD patients exhibit abnormalities in coagulation and fibrinolysis, have an increased throm- bin generation and a significant presence of this ...

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Increased mucosal thrombin is associated with Crohn's disease and causes inflammatory damage through Protease-Activated Receptors activation

Increased mucosal thrombin is associated with Crohn's disease and causes inflammatory damage through Protease-Activated Receptors activation

... We then investigated whether the proinflammatory effects of thrombin administered into the colon of mice were dependent on the activation of PAR1, the first identified thrombin receptor. 27 , 28 We first used a ...

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Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1

Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1

... F IG . 5. SUMO-1 expression enhances PR-SRC-1 interaction in vivo. The effect of SUMO-1 on the formation of PR-SRC-1 complexes was analyzed by the two-hybrid system in CV-1 cells. The ...

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Resistance testing in children changing human immunodeficiency virus type 1 protease inhibitor

Resistance testing in children changing human immunodeficiency virus type 1 protease inhibitor

... Objective. To assess genotypic and phenotypic resistance testing in HIV-1-infected children failing a first protease inhibitor (PI) therapy. Methods. In a multicenter observational study 21 children, ages 3 ...

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Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2

Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2

... Nicolas Cénac, Anne Marie Coelho, Cathy Nguyen, Steven Compton, Patricia Andrade-Gordon, Wallace K Macnaughton, John L Wallace, Morley D.. Hollenberg, Nigel W Bunnett, Rafael Garcia Vill[r] ...

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Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma.

Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma.

... after 1 day of differentiation coincident with cell cycle entry ...days 1-2 and decreased thereafter, whereas expression of PPARγ increased strongly from day 1 through the end of ...

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Skeletal muscle Heat shock protein 60 increases after endurance training and induces peroxisome proliferator-activated receptor gamma coactivator 1 α1 expression

Skeletal muscle Heat shock protein 60 increases after endurance training and induces peroxisome proliferator-activated receptor gamma coactivator 1 α1 expression

... α 1, or a co-activating activity of Hsp60 on the promoter of the PGC1 α1 gene has not yet been described in the ...AMPKα 1, AMPKα 2, p-AMPKα , 4 HNE, MnSOD, and TFAM in both skeletal muscle tissue (soleus) ...

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NRIP1 (nuclear receptor interacting protein 1)

NRIP1 (nuclear receptor interacting protein 1)

... nuclear receptor mediated gene expression including gene expression mediated by the estrogen receptor, liver X receptor, PPARs, steroidogenic factor 1 (SF1) and ...

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Complex receptor-ligand dynamics control the response of the VEGF system to protease injury

Complex receptor-ligand dynamics control the response of the VEGF system to protease injury

... VEGF receptor interac- tions in a more complex manner (Figure ...(Model 1), VEGFf did not increase overall VEGF binding to VEGFR2 and had only a limited ...

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Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain

Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain

... Surprisingly, in the TNBS colitis model the colo- rectal hyperalgesia was augmented by blocking PAR-4 with an antagonist. This suggests the presence of an endogenous activation of PAR-4 in colonic inflamma- tion, ...

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Current concepts regarding the HTLV-1 receptor complex.

Current concepts regarding the HTLV-1 receptor complex.

... the receptor complex are up-regu- lated on most transformed ...HTLV-1 receptor complex is present on cell lines from nearly all known vertebrate species [36]: most available established cell lines ...

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Peroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A

Peroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A

... (Figure 1) is used to produce fireproof epoxy resins used in the manufacture of computer motherboards and other electronics; and it has been found in the environment (de Wit et ...(Figure 1) is also used as ...

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Peroxisome Proliferator-Activated Receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

Peroxisome Proliferator-Activated Receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

... lanes 1, 2) and hPPAR␥-transduced cells ...lanes 1, 3) or with a flag-tagged substrate for ␥-secretase, representing the C-terminal 100 amino acids from APP (APP C100-flag) ...

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Expression and regulation of protease nexin-1 and plasminogen activators in bovine ovarian follicles

Expression and regulation of protease nexin-1 and plasminogen activators in bovine ovarian follicles

... The objective of this study xvas to determine if celi-specific and temporal regulation ofPN-l and PA expression and secretion contribute to follicular developrnent and ovulation in catti[r] ...

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Tachykinin NK1 receptors are involved in proteinase-activated receptor-2-mediated visceral hyperalgesia in rats

Tachykinin NK1 receptors are involved in proteinase-activated receptor-2-mediated visceral hyperalgesia in rats

... Bruno Guiard, Nicolas Cenac, Rafael Garcia Villar, Anne-Marie Coelho, Jean Fioramonti, Lionel Bueno. To cite this version:[r] ...

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Tachykinin NK1 receptors are involved in proteinase-activated receptor (PAR)-2-mediated colonic inflammation in mice

Tachykinin NK1 receptors are involved in proteinase-activated receptor (PAR)-2-mediated colonic inflammation in mice

... Version preprint Comment citer ce document : Cenac, N., Guiard, B., Garcia Villar, R., Fioramonti, J., Bueno, L. (2001). Tachykinin NK1 receptors are involved in proteinase-activated receptor ...

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