Proprotein convertases
The multifaceted proprotein convertases PC7 and furin : identification of new substrates and physiological relevance
... The proprotein convertases play key roles in both health and disease states by cleavage of precursor proteins (440), which results in the bioactivation of proteins, but sometimes may also generate cleaved ...
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Characterization of Endoproteolytic Processing of Dynorphins by Proprotein Convertases using Mouse Spinal Cord S9 Fractions and Mass Spectrometry
... Full-length peptides, BDyn and Dyn A, were incubated for 30 minutes in mouse spinal cord S9 fractions and following the reaction termination, supernatant were analyzed [r] ...
32
Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System
... Interestingly, even though the infection was shown to be productive for both variants in primary CNS cultures from BALB/c mice, there was a significant increase in the total amount of in[r] ...
25
The role of protein convertases in bigdynorphin and dynorphin A metabolic pathway
... proteolysis. Proprotein convertases (PCs) are widely expressed in the central nervous system and specifically cleave at C-terminal of either a pair of basic amino acids, or a single basic ...
126
The Role of a Proprotein Convertase Inhibitor in Reactivation of Tumor-Associated Macrophages and Inhibition of Glioma Growth
... a proprotein conver- tases inhibitor. Proprotein convertases process immature pro- teins into functional proteins, with several of them having a role in immune cell activation and ...the ...
17
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model
... * Corresponding author Abstract Background: The secretory basic amino acid-specific proprotein convertases (PCs) have often been associated with cancer/metastasis. By controlling the cleavage of ...
9
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: In vivo mouse model
... * Corresponding author Abstract Background: The secretory basic amino acid-specific proprotein convertases (PCs) have often been associated with cancer/metastasis. By controlling the cleavage of ...
9
The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways
... but is necessary for its proteolytic cleavage at a neutral pH, possibly in early endosomes or in a pre-endosomal compartment such as the ER, Golgi, or plasma membrane 30 . This finding is consistent with the reported ...
14
Utilisation du ribozyme delta pour évaluer les fonctions spécifiques des proprotéines convertases dans un contexte cellulaire normal ou pathologique
... En effet, bien qu'aucun defaut cellulaire n'ait jusqu'a maintenant ete identifie chez nos cellules |3TC-3 deficientes en PC2, les cellules DU145 avec une expression [r] ...
209
Mécanisme de ciblage des prohormones convertases vers les granules de sécrétion denses
... CPE preferentially binds sphingolipids and cholesterol-rich membrane fractions (60) while both the prohormone convertases PC1/3 (46) and PC2 (47) bind liposomes enriched in sphingolipids and cholesterol. The lipid ...
192
Letter From Le May and Cariou Regarding Article, "Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor-Dependent and -Independent Mechanisms"
... S. Proprotein convertase subtilisin kexin type 9 promotes intesti- nal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -inde- pendent ...
3
Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9
... Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important factor in plasma cholesterol regulation through modu- lation of low density lipoprotein receptor (LDLR) levels. Naturally occurring mutations ...
17
The proprotein convertase ski-1/s1p in vitro analysis of lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors
... secreted convertases (2) furin at pH 7 and 6 (because processing of both pro- SREBP-2 and pro-ATF6 occurs in the medial Golgi with an intraluminal acidic pH), and PACE4/PC5A at pH ...latter convertases are ...
12
Development of Protein-based Inhibitors of the Proprotein of Convertase SKI-1/S1P PROCESSING OF SREBP-2, ATF6, AND A VIRAL GLYCOPROTEIN
... Processing of membrane-bound transcription factors such as sterol regulatory element-binding proteins (SREBPs) and the ER-stress response factor ATF6, and glycoproteins of some hemorrhagic fever viruses are initiated by ...
11
C-terminal proteolysis of the collagen VI α3 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes
... Two proteases were identified as being involved in the com- plex proteolytic processing of the collagen VI ␣3 chain C ter- minus: BMP-1 cleaving off the C5 domain (endotrophin) and a proprotein convertase of the ...
15
Characterisation of structural determinants and molecular mechanisms involved in Stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases.
... junction with the catalytic domain [1,9]. Comparable stretches of amino acids have been described in the membrane-type MMPs [16,17], and have been proposed to play a role in zymogen activation because they each contain a ...
6
Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals
... press pro-MCH and different prohormone convertases, namely furin, PACE4, PC1/3, PC2, PC2 with various forms of 7B2, PC5/6-A, PC5/6-B, and PC7. Thereafter, peptides produced and MCH precursor were identified by ...
11
Proprotein convertase subtilisin/kexin type 9 in human disease
... Proprotein convertase subtilisin/kexin 9 (PCSK9), a member of the proprotein convertase family, is indirectly associated with CVD through enhanced LDLR degradation. Mutations in the hu[r] ...
149
Inhibition cellulaire de la proprotéine convertase 1 et activité des proprotéines convertases dans le réticulum endoplasmique
... Résumons ainsi le profile de maturation du proCT et du pro*CT: très tôt dans la voie sécrétoire, dans les 15 premières minutes suivant la synthèse, proCT est clivé au site primaire du pr[r] ...
91
L'implication des convertases de pro-protéines dans la maturation de nouveaux substrats membranaires aux motifs de clivage atypiques
... in vitro de peptides comprenants le site de clivage de l’Œ4 muté en P6 démontrent que PC5 dépend moins d’un résidu chargé en P6 que la furine, même si les résidus acides du sous- sites S[r] ...
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