Preclinical models
HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models
... In vitro and in vivo experiments have demonstrated that HER2-containing heterodimers elicit greater mitogenic responses than HER2 homodimers. Thus, ligand- induced activation of EGFR or HER3 and formation of heterodimers ...
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en fr Development of Magnetic Resonance Imaging (MRI) methods for in vivo quantification of lipids in preclinical models. Développement de méthodes d'Imagerie par Résonance Magnétique pour la quantification des lipides in vivo dans les modeles precliniques
... vivo non-invasive fat quantitation in preclinical models. Differently from the MR phantoms, the mice breathe and can move during the MR acquisitions, leading to the formation of motion artifacts. Magnetic ...
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Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.
... examine preclinical heterogeneity will be conducted on the primary ...among preclinical studies will be compared to those already described in Humans (and those that could be identified in the future) using ...
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Antitumor activity of abnormal cannabidiol and its analog O-1602 in taxol-resistant preclinical models of breast cancer
... Most studies up to now have used mice for preclinical in vivo studies to assess the anticancer efects of cannabinoids. Here, we used zebraish (D. rerio) as our screening model for drug efect on cancer viability in ...
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en fr Physiopathology of mantle cell lymphoma from mechanistic to preclinical models Physiopathologie du lymphome à cellules du manteau : de la mécanistique aux modèles précliniques
... Le lymphome à cellules du manteau (LCM) est une hémopathie maligne B mature, appartenant à la famille des lymphomes non hodgkiniens. Afin de mimer de la manière [r] ...
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Innovative preclinical models for pulmonary drug delivery research
... routes, etc… all combinations and time scheduling of in-silico, in-vitro, ex-vivo and in-vivo experimentation may be scientifically sound. Dogmatic classical views such as experimenting from in-silico to in-vivo as a ...
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Radiation Dose-Enhancement Is a Potent Radiotherapeutic Effect of Rare-Earth Composite Nanoscintillators in Preclinical Models of Glioblastoma
... 3. Conclusion In conclusion, our findings elucidate three critical points regard- ing the use of rare-earth composite nanoscintillators for radiation therapy. First, we discovered that rare-earth composite nanoscin- ...
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Combining the DNA Repair Inhibitor Dbait With Radiotherapy for the Treatment of High Grade Glioma: Efficacy and Protein Biomarkers of Resistance in Preclinical Models
... In models with a constitutive high level of NBS1 and H2AX activations, low-dose Dbait failed to enhance these disturbances once more and higher concentrations were ...
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HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical Models
... animal models suggest that even though both mature and newly differentiated OLs can produce myelin sheaths, it is newly differentiated OLs, rather than mature OLs, that orchestrate remyelination in adult brain ...
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Cellular immunotherapy in multiple myeloma : lessons from preclinical models
... murine models of MM have been established and have been of value for the preclinical investigation of MM immunotherapy ( Table 1 ...ficient models have been developed to assess the effectiveness of ...
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Long-term evolution of the epithelial cell secretome in preclinical 3D models of the human bronchial epithelium
... vitro models of the human lung are essential for screening the epithelial response and assessing the toxicity and barrier crossing of drugs, inhaled particles, and ...of models to investigate the effect of ...
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From cerebral palsy to developmental coordination disorder: Development of preclinical rat models corresponding to recent epidemiological changes
... rat models appear to recapitulate the diversity of symptoms ranging from CP to DCD and contribute to understanding the emergence and mechanisms underlying the corresponding neurodevelopmental ...These ...
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A Novel Telemanipulated Robotic Assistant for Surgical Endoscopy: Preclinical Application to ESD
... Fig. 6 shows the theoretical workspaces of the instruments, obtained from the kinematic models of the instruments ([22]). These are truncated cylinders [22] of radius 32 mm and height 75 mm. Measured trajectories ...
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Preclinical longitudinal imaging of tumor microvascular radiobiological response with functional optical coherence tomography
... his study presents comprehensive experimental results from in-vivo pancreatic human tumor xenograts sub- jected to three diferent radiation dose levels, with noninvasive imaging performed for up to 8 weeks following dose ...
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Preclinical Alzheimer's disease: a systematic review of the cohorts underlying the concept
... in preclinical AD descriptions [7, 16-18], also raises some issues: if it is too strict ...of preclinical AD, the cognitive decline is not mandatory for ...of preclinical AD recognize that the ...
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Physicochemical characterization and biocompatibility studies of persistent luminescence nanoparticles for preclinical diagnosis applications
... These analytical methodologies show the application of capillary electrophoresis in the Hummel- Dreyer and Affinity modes according to the interaction parameters, for the eval[r] ...
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Latent class analysis identifies functional decline with Amsterdam IADL in preclinical Alzheimer's disease
... disease [22,23] . Second, participants with poorer performances in IADLs also had higher brain amyloid burden. This result is particularly interesting if we consider that our sample included cognitively healthy ...
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View of Neglecting the null: the pitfalls of underreporting negative results in preclinical research
... in preclinical research. Consider- ing that preclinical research provides the foundation on which many clinical trials are conceived, finding solutions to increase the reporting accuracy of ...
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Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease
... animal models of PD, like in the MitoPark mice [ 58 ] and after the intranasal administration of MPTP [ 59 ], reinforcing the cognitive aspect of PD and the importance of Parkin in this ...
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