Preclinical model
Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases
... Keywords: halofuginone, osteosarcoma, TGF- β, metastases, bone remodeling Received: February 04, 2015 Accepted: April 24, 2015 Published: May 07, 2015 ABSTRACT Osteosarcoma is the main malignant primary bone tumor in ...
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Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis
... 1HYHUWKHOHVVRXUILQGLQJVWKDWApc Min/+ Il10 -/- DQGApc Min/+ VPDOOLQWHVWLQHWXPRU.. Version postprint. Comment citer ce document :[r] ...
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In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact
... To evaluate the proliferation ratio of SW1353 cells in the 3DCM, we measured Ki67 index by IHC-p. Indeed, Ki67 index was previously described as a potential marker to assess tumor grade in CHS and determine the prognosis ...
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MRI assessment of treatment delivery for interstitial photodynamic therapy of high-grade glioma in a preclinical model
... Based on the immunohistology data, the MRI results appeared consistent, particularly for the extent of necrosis, rarefaction of the vascular pattern in the treated area, and perilesional edema. Furthermore, variation of ...
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Pomegranate Peel Extract Prevents Bone Loss in a Preclinical Model of Osteoporosis and Stimulates Osteoblastic Differentiation in Vitro
... culture model with osteoblasts and osteoclasts, we studied the cellular and molecular mechanisms of action that could be involved, and thanks to a murine model of osteoporosis we attempted to confirm ...
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Zoledronic acid inhibits pulmonary metastasis dissemination in a preclinical model of Ewing's sarcoma via inhibition of cell migration.
... amputation model, arise later during the tumor de- velopment and represent spontaneous metastases, needing cell migration and invasion to ...prostate). Preclinical studies reported that BPs may prevent ...
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[18F]ML-10 PET imaging fails to assess early response to neoadjuvant chemotherapy in a preclinical model of triple negative breast cancer
... our model between the fixation of [ 18 F]ML-10 and [ 18 ...this model, no significant in- crease in [ 18 F]ML-10 tumor uptake was observed dur- ing apoptosis induced by ...
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The timing of surgery after neoadjuvant radiotherapy influences tumor dissemination in a preclinical model
... The reductionist view of a tumor composed only of cancer cells has remarkably evolved and the implication of the tumor microenvironment during cancer progression is now well established [8]. The various molecular and ...
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Pulmonary hypertension after pneumonectomy: a preclinical model in rats and human pulmonary endothelial cells
... Pierre Sentenac, Gianluca Samarani, Patrice Bideaux, Pierre Sicard, Benjamin Bourdois, Sylvain Richard, Pascal Colson, Saadia Eddahibi. To cite this version:[r] ...
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Fischer 344 Rat: A Preclinical Model for Epithelial Ovarian Cancer Folate-Targeted Therapy
... Here, we have demonstrated that NuTu-19 cells express FR α in vitro and in vivo. As already shown by several authors who have stated that membrane anchored FRα can mediate internalization of receptor-bound folate ...
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Chronic renoprotective effect of pulsatile perfusion machine RM3 and IGL-1 solution in a preclinical kidney transplantation model
... In a previous study, we measured the benefits of MP versus static cold storage (CS) using the Waters RM3 system in a preclinical model of DCD kidney transplant- ation in pigs [11,12]. In the same study, we ...
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Role of warm ischemia on innate and adaptive responses in a preclinical renal auto-transplanted porcine model.
... Results Severe IRI affects early renal function in preclinical model WI increased CS-induced delayed graft function recov- ery and chronic dysfunction. A significant increase in creatininemia was observed ...
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A Novel Metamaterial-Inspired RF-coil for Preclinical Dual-Nuclei MRI
... thickness of 0.5 mm, the FOV was 80 × 32 mm, the number of averages was 1 and the flip angle was 90° (see the obtained whole-body image in Fig. 8(b) ). Conclusion In this work, a new design for a dual-nuclei ...
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A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps
... For Human studies, to facilitate data storage, data sharing and data processing with specific pipelines, several infrastructures have been proposed such as COINS ( Landis et al., 2016 ), LORIS + BRAIN ( Das et al., 2016 ...
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Requirement for preclinical prioritization of neuroprotective strategies in stroke: Incorporation of preconditioning
... in vitro (Moskowitz et al., 2010).) ….Requires Prioritization Second, “lessons learned” have been largely focused on improving the process of testing/verifying a therapeutic, but not on how to choose a therapeutic. The ...
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Analysis of machine perfusion benefits in kidney grafts: a preclinical study
... for preclinical studies as it is close to humans, par- ticularly in regards to the multipapillar multilobular orga- nization of its kidney, only found in higher mammals, implying a complex vascular bed making ...
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Chemical and biological evaluations of an (111)in-labeled RGD-peptide targeting integrin alpha(V) beta(3) in a preclinical tumor model.
... Mitra Ahmadi, Lucie Sancey, Arnaud Briat, Laurent Riou, Didier Boturyn, Pascal Dumy, Daniel Fagret, Catherine Ghezzi, Jean-Philippe Vuillez. To cite this version:[r] ...
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Preclinical Alzheimer's disease: a systematic review of the cohorts underlying the concept
... no preclinical AD subject was included in the study), “neuropathological” (when AD diagnosis was pathologically established in subjects who died within one year of a cognitive evaluation considered as unimpaired), ...
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Multi-Modality Diffuse Fluorescence Imaging Applied to Preclinical Imaging in Mice
... = ∫ (4.11) The detail of the equation derivation could be found elsewhere (Yalavarthy, Pogue, Dehghani, & Paulsen, 2007). Here, the symbol Φ meas is the experiment measurement, in our case, the fluorescence data ...
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Latent class analysis identifies functional decline with Amsterdam IADL in preclinical Alzheimer's disease
... priate approach for our purpose. LCLMM identifies groups of subjects on the basis of a given criterion (here, perfor- mance on IADLs over the 3 years) and then compares them to a reference group. In this way, it allows ...
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