PI3K pathway
Inhibition of PI3K pathway increases immune infiltrate in muscle-invasive bladder cancer
... the PI3K pathway effectively increased immune infiltration of PIK3CA-mutated bladder tumors, thus transforming “cold” tumors into “hot” tumors, which is thought to represent a key step in obtaining ...
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A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)–p85 to Filamin A Negatively Controls the PI3K Pathway
... (PI3K) pathway, urging identification of novel negative ...restraining PI3K activity, controlled by the somatostatin G protein- coupled receptor (GPCR) sst2 and involving a ligand-regulated ...
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Infection with genotoxin-producing Salmonella enterica synergises with loss of the tumour suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells
... of PI3K, stimulating the kinase activity (Chen et ...the PI3K pathway in CRC cells (Qi et ...the PI3K/AKT pathway activation, downregulation of p21, likely medi- ated by the AKT ...
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Molecular profiles of quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets
... The PI3K/Akt pathway plays a pivotal role in the promo- tion of cell proliferation and inhibition of cell ...and PI3K pathways, which influence proliferation and cell survival, respec- ...of ...
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Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes
... the PI3K pathway To confirm the role of PI3K pathway in upregulating glucose uptake in adipocytes by UA, we further determined the expression or the activity of key proteins of this ...
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The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism
... the PI3K pathway to counteract gefitinib resistance and suggest that this approach should be evaluated further for lung cancer patients with wild-type EGFR and mutant ...of PI3K inhibitors are cur- ...
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Is there a role for dual PI3K/mTOR inhibitors for patients affected with lymphoma?
... the PI3K/mTOR signaling cascade. 3. PI3K Pathway and Metabolism PI3K signaling is activated upon grow factor stimulation and grow factor receptors activation, including insulin receptor ...
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NOTCH pathway inactivation promotes bladder cancer progression
... NOTCH pathway could be oncogenic in bladder cancer (37, 38), there is substantial evidence indicating a tumor-suppressive ...NOTCH pathway plays a relevant tumor-sup- pressive role in bladder ...NOTCH ...
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UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway
... Fan Zhang 1 , Hui-zeng Lv 2 , Ji-ming Liu 2 , Xiao-yong Ye 2 , Cun-chuan Wang 1* > Colon cancer is a common cause of cancer- related death worldwide. However, the underlying mechanism of tumor progression of colon ...
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The hedgehog pathway and ocular developmental anomalies
... promote pathway activation, but it is simul- taneously required in regions of low HH activity (distal) to maintain the pathway in a repressed state ...
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The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
... 3 PI3K await ...3 PI3K in maintenance of metabolic ...3 PI3K orchestrates liver energy metabolism through the control of endocytosis, lysosomal path- way of autophagy and transcriptional control of ...
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Electric vehicle as a pathway for deep decarbonization
... General conclusions and future perspectives The main goal of this PhD thesis is to obtain the maximum penetration of electric vehicles as a pa- thway for deep decarbonization pathway project. In order to reach ...
170
The LKB1 complex-AMPK pathway: the tree that hides the forest.: The LKB1 complex-AMPK pathway
... salt-induced kinase 1) has been described to play a role in steroidogenesis and TGF signalling, for this latter by inhibiting SIK1 ( β type I TGF receptor kinase β [84 ] . More recently, SIK1 was also found to have a ...
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Signaling pathway switch in breast cancer.
... the PI3K/AKT and JUN/MAPK ...signaling pathway in the presence of oxida- tive ...the PI3K/AKT and inhibition of JUN/MAPK pathways overrules the tumor suppressive effect of FOXOs and allows G1 ...
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A journey through the exocytic pathway
... retrieval pathway, whereas cargo is collected at the trans ...constitutive pathway, others are sorted via regulated pathways to, for example, secretory granules, secretory lysosomes, such as melanosomes ...
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Bladder cancer and the Notch pathway
... Notch pathway Pablo ...Notch pathway in cancer has been known since it was found hyperactivated in acute T-cell lymphoblastic leukemias (T-ALL) one decade ...Notch pathway and cancer has been ...
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Pathophysiologie des défauts génétiques du Lupus Erythémateux disséminé pédiatrique : implications du stress du réticulum endoplasmique et de la voie PI3K dans le développement de l’auto-immunité
... Notre projet a permis de mettre à jour deux nouvelles mutations résidant dans les gènes ERN1 et PIK3R2. ERN1, codant IRE1a, est le principal inducteur d’un programme transcriptionnel activé en réponse à l’accumulation ...
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ICOS Ligation Recruits the p50{alpha} PI3K Regulatory Subunit to the Immunological Synapse.: ICOS-p50α interactions
... The p85α and p50α regulatory subunits are derived by alternative splicing of the same gene pik3r1 (31). These molecules share two SH2 domains, the p110-binding inter-SH2 domain and a proline-rich region. They differ in ...
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SHH Signaling Pathway Drives Pediatric Bone Sarcoma Progression
... (SHH) pathway has taken place within the cancer research ...signaling pathway in skeletal development, pediatric bone sarcoma progression and the related therapeutic options that may be possible for these ...
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Leptin Modulates the Expression of miRNAs-Targeting POMC mRNA by the JAK2-STAT3 and PI3K-Akt Pathways
... JAK2-STAT3, PI3K-Akt, and MEK 1/2/ERK pathways within POMC neurons ...JAK2-STAT3, PI3K-Akt, and MEK 1/2/ERK pathways, ...JAK2-STAT3 pathway by pre- treatment with cryptotanshinone (1 μM) for 24 h ...
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