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PI3K-AKT signaling

UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway

UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway

... on PI3K/Akt signaling ...of Akt and its downstream effector mTOR, and reduced the expression of ...the PI3K/AKT signaling ...

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JTC-801 Suppresses Melanoma Cells Growth through the PI3K‑Akt‑mTOR Signaling Pathways

JTC-801 Suppresses Melanoma Cells Growth through the PI3K‑Akt‑mTOR Signaling Pathways

... the PI3K-Akt signaling pathway has been suggested to be a critical regulator mediating resistance to MAPK inhibitors [26, ...the PI3K-Akt pathway as the putative target of JTC- ...

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Lycorine inhibits melanoma A375 cell growth and metastasis through the inactivation of the PI3K/AKT signaling pathway

Lycorine inhibits melanoma A375 cell growth and metastasis through the inactivation of the PI3K/AKT signaling pathway

... Key words: Lycorine; melanoma; proliferation; migration; apoptosis; PI3K/AKT signaling pathway. [1, 2] . Although a lot of efforts have been made to improve mela- noma treatment recently, the overall ...

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Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways

Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways

... Rho-kinase signaling pathway and reduced bile acid ...the PI3K/ AKT ...and PI3K/AKT signaling pathways and consequently support the conclusion that in clinic they can cause a ...

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The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism

The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism

... elevated AKT activity is prevalent in high-grade, advanced tumors and is associated with metasta- sis, radioresistance and reduced patient ...phosphorylated AKT, 11,24,25 and their gefitinib responsiveness ...

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Constitutive AKT activation in follicular lymphoma.

Constitutive AKT activation in follicular lymphoma.

... the PI3K/AKT signaling pathway in MCL occurs most frequently by loss of PTEN expression and/or PIK3CA gene amplification, whereas the PIK3CA gene was found unmutated ...frequent AKT activating ...

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Akt signaling pathway: a target for radiosensitizing human malignant glioma

Akt signaling pathway: a target for radiosensitizing human malignant glioma

... that Akt pathway activation is closely related to human glioma ...that PI3K/Akt signaling pathway down modulation led to persistence of unrepaired DSBs induced by radiation in a human ...

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The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.

The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.

... Figure 5. The src kinase c-yes orchestrates the cl-CD95L-mediated PI3K/Akt signaling pathway and cell migration. (A) Upper panels: T- leukemic cell line H9 was transiently transfected with Lck-GFP. ...

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Leptin Modulates the Expression of miRNAs-Targeting POMC mRNA by the JAK2-STAT3 and PI3K-Akt Pathways

Leptin Modulates the Expression of miRNAs-Targeting POMC mRNA by the JAK2-STAT3 and PI3K-Akt Pathways

... the PI3K-AKT-mTOR signaling pathway to inhibit development of cervical cancer via down-regulating Poly (ADP-ribose) polymerase-2 [ 45 ...mTOR signaling pathway is essential for POMC neuron ...

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Role of akt activation in PARP inhibitor resistance in cancer

Role of akt activation in PARP inhibitor resistance in cancer

... of Akt Protein kinase B/Akt, a 57-kDa serine/threonine kinase, is regarded as a pivotal mediator of cell survival promoting effects of various growth factors and other factors, including cAMP, hypoxia, and ...

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Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML

Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML

... of signaling cascades, we examined the enrichment of signaling pathways in resistant cell ...and AKT pathways in both MOLM-13- (Figure 3d) and MV4-11- (Figure 3e) resistant cell ...and AKT ...

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PTEN-regulated AKT/FoxO3a/Bim signaling contributes to Human cell glioblastoma apoptosis by platinum-maurocalcin conjugate

PTEN-regulated AKT/FoxO3a/Bim signaling contributes to Human cell glioblastoma apoptosis by platinum-maurocalcin conjugate

... of AKT on FoxO3a and its downstream targets after treatment by Pt-1-DMCa since AKT was demonstrated to be notably activated in multiple malignant tumors, such as ...targeting AKT could be important ...

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Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: Its potential use in the treatment of bladder cancers.

Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: Its potential use in the treatment of bladder cancers.

... this signaling pathway, at serine 2448 (Inoki, Li, Xu, & Guan, ...(proline-rich Akt substrate 40 kDa), mLST8 (mammalian Lethal-with-Sec-Thirteen 8), FKBP38 (FK506 Binding Protein 38), Raptor (Regulatory ...

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Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes

Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes

... the PI3K pathway, phosphoinositide-dependent kinase (PDK) and phosphoinositide-dependent serine/threoninekinase (AKT) were increased by 10 mM of UA in the presence of ...the PI3K inhibitor was ...

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Low-Molecular-Weight Fucoidan Induces Endothelial Cell Migration via the PI3K/AKT Pathway and Modulates the Transcription of Genes Involved in Angiogenesis

Low-Molecular-Weight Fucoidan Induces Endothelial Cell Migration via the PI3K/AKT Pathway and Modulates the Transcription of Genes Involved in Angiogenesis

... the PI3K/AKT pathway (such as migration, remodeling of cytoskeleton, chemotaxis, mobilization, rolling and adhesion), it is possible that the activation of this pathway by LMWF subsequently leads (directly ...

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Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells

... AMPK, Akt, and NADH indices triggered by inhibition of ...and Akt index (E) for the indicated concentrations of ...and Akt indices (F) or AMPK and Akt indices (G) within the same ...and ...

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Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

... insulin/IGF-1 signaling are the most robust and reproducible inter- ventions for extending lifespan and preventing or delaying age- related disease in a variety of species (Anderson & Weindruch, 2007; Kennedy ...

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AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

... Our AKT signaling results differ from studies in which mutant PIK3CA was expressed ectopically in cell culture/chick embryo models ( Isakoff et ...steady-state AKT signaling is reduced in many ...

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A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)–p85 to Filamin A Negatively Controls the PI3K Pathway

A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)–p85 to Filamin A Negatively Controls the PI3K Pathway

... inhibitory signaling pathways such as tyrosine phosphatases SHP-1 and SHP-2 and the tyrosine kinases src and JAK2 (16, 17, ...the PI3K regulatory p85 subunit ...

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Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway.

Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway.

... with Akt signaling, p27 and p70SK6, became ...the Akt pathway, we also observed STAT5/6 pro- teins being less frequently phosphorylated after DC ...

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