peroxisome proliferator-activated receptors (PPARs)
Placental Implications of Peroxisome Proliferator-Activated Receptors in Gestation and Parturition
... the peroxisome proliferator-activated receptors (PPARs) are known to be involved in the physiological and pathological events occurring during the ...
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Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
... includes receptors for sexual and adrenal steroids, retinoids, thyroid hormone, vitamin D, ecdysone, and a number of receptors whose ligands are still unknown and therefore are called orphan ...
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Nuclear control of the inflammatory response in mammals by peroxisome proliferator-activated receptors.
... IL1Ra mRNA levels IL1 � Figure 2: Representative illustration of PPAR main targets in inlammatory diseases. PPAR � mostly displays anti-inlammatory properties in the context of liver inlammation. Its reported liver ...
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Peroxisome proliferator-activated receptor-γ activation induces 11β-hydroxysteroid dehydrogenase type 1 activity in human alternative macrophages.
... nuclear receptors, such as the Peroxisome Proliferator-Activated Receptors (PPARs) , / and α β δ γ [ 9 ] and the ...is activated by natural (15-deoxy- 12, 14-prostaglandin J2 ...
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Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism
... Peroxisome proliferator–activated receptors (PPARs; isotypes , / , ) are ligand-inducible nuclear transacting factors ...to peroxisome proliferator– activated receptor ...
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Src is activated by the nuclear receptor peroxisome proliferator-activated receptor beta/delta in ultraviolet radiation-induced skin cancer
... the peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor superfamily, in tissue repair (Michalik et al, ...
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Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease
... become activated, and endoplasmic reticulum (ER) and oxidative stress increase, leading to pro-inflammatory cytokine production, lipid peroxidation, hepatocyte cell death (apoptosis and necrosis), and aggravated ...
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A role for peroxisome proliferator-activated receptor gamma in resveratrol-induced colon cancer cell apoptosis.
... To further assess the role of PPARγ in this death pathway, we transiently transfected SW480 colon cancer cells with constructs encoding a double dominant-negative mutant of PPARγ that retains its ligand and DNA-binding ...
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Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm
... schedule is an important external cue that contributes to the adjustment of the peripheral circadian clocks located in different organs [ 28 , 40 ]. At the molecular level, the circadian clock is driven by several ...
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Rôle des Peroxisome Proliferator-Activated Receptors (PPAR) dans le métabolisme lipidique
... A partir des années 1970, des médicaments dénommés fibrates ont été prescrits chez ces patients dyslipidémiques et ont rapidement fait preuve de leur intérêt clinique. En effet ils ont montré abaisser les concentrations ...
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The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential
... The PPAR subfamily of nuclear receptors comprises three isotypes: PPARα, PPARβ/δ and PPARγ, each encoded by separate genes and with a unique albeit overlapping tissue distribution. These three isotypes share a ...
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Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock.
... hormone receptors such as Rev-erbα, as fenofibrate, a PPARα agonist, induces human and rat rev-erb α expression in liver through the direct binding of PPARα on an atypical DR2 element located in the rev-erb α ...
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Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2.
... involved in preadipocyte growth and/or differentiation (see reference 2 for review). Lysophosphatidic acid (LPA) is a potent bioactive phospholipid able to regulate several cellular responses via activation of specific ...
21
Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator–activated receptor γ activator–mediated inhibition of dendritic cells
... PPAR subtypes have been identified, alpha, delta and gamma, and are ligand-activated nuclear receptors which can be activated by polyunsaturated fatty acids, eicosanoids, and various synthetic ...
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Tissue-specific differential induction of duplicated fatty acid-binding protein genes by the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio)
... and peroxisome proliferators activate these nuclear receptors, and once activated, these nuclear receptors form heterodimers with retinoic-acid receptors (RAR) or retinoid X ...
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Peroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A
... by peroxisome proliferator–activated receptor γ (PPARγ), a nuclear hormone receptor whose dysregulation is involved in the onset of diabetes and obesity (Swedenborg et ...
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Death receptors as targets in cancer
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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AMP-Activated Protein Kinase Signalling
... 22. Didier, S.; Sauve, F.; Domise, M.; Buee, L.; Marinangeli, C.; Vingtdeux, V. AMP-activated protein kinase controls immediate early genes expression following synaptic activation through the pka/creb pathway. ...
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Activated diffusiophoresis
... are activated in the form of traveling “pulses”, as in ...of activated processes, and we also expect it to be experimentally feasible to apply such activations to ...
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Activité physique et prévention de l'arthérosclérose : Mise en évidence de l’implication des PPAR (Peroxisome Prolife- raor-Activated Receptor) dans la cardioprotection induite par l’exercice physique soumis ou volontaire chez la souris ApoE-/- mice
... Mazzolai L, Duchosal MA, Korber M, Bouzourene K, Aubert JF, Hao H, Vallet V, Brunner HR, Nussberger J, Gabbiani G, et al.: Endogenous angiotensin II induces atherosclerotic plaque vulne[r] ...
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