peroxisome proliferator activated receptor gamma
A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis
... antitopoisomerase I) and presence/absence of interstitial lung disease and pulmonary hypertension. Abbreviations ACA: anticentromere antibodies; ACR: American College of Rheumatology; ATA: anti-topoisomerase I ...
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Skeletal muscle Heat shock protein 60 increases after endurance training and induces peroxisome proliferator-activated receptor gamma coactivator 1 α1 expression
... Heat shock protein 60 (Hsp60) is a chaperone localizing in skeletal muscle mitochondria, whose role is poorly understood. In the present study, the levels of Hsp60 in fibres of the entire posterior group of hindlimb ...
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Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis.
... the peroxisome proliferator-activated receptor gamma (PPARγ (reviewed in (14, 15)), which is induced during the initial phases of these terminal stages of adipogenesis by C/EBPβ and δ, ...
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A role for peroxisome proliferator-activated receptor gamma in resveratrol-induced colon cancer cell apoptosis.
... are other actors playing a role in the molecular effect [15]. Among the different potential candidates, the nuclear transcription factor PPARγ (Peroxisome Proliferator-Activated Receptor ...
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Peroxisome Proliferator-Activated Receptor gamma enhances the activity of a insulin degrading enzyme-like metalloprotease for amyloid-beta clearance.
... Abstract. Peroxisome proliferator-activated receptor gamma (PPARγ) activation results in an increased rate of amyloid-β (Aβ) clearance from the media of diverse cells in culture, ...
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Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma.
... Abstract In addition to their role in cell cycle progression, new data reveals an emerging role of D-type cyclins in transcriptional regulation and cellular differentiation processes. Using 3T3-L1cell lines to study ...
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Peroxisome proliferator‐activated receptor gamma‐ligand‐binding domain mutations associated with familial partial lipodystrophy type 3 disrupt human trophoblast fusion and fibroblast migration
... loop linking H5 and H6 (L5-6), which both contain residues of the LBP (Figure 5C). By destabilizing the helical conformation of H2 (the glycine amino acid is known to be an α-helix breaker) and sup- pressing the ...
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Peroxisome Proliferator-Activated Receptor gamma induces a clearance mechanism for the amyloid-beta peptide.
... whether peroxisome proliferator-activated receptor ␥ (PPAR␥) could be involved in the modulation of the amyloid cascade causing Alzheimer’s ...
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Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer.
... Introduction Prostate cancer is the most common form of cancer in men, and the second leading cause of 15 cancer deaths. Tumor growth is originally androgen dependent. Androgens exert their effects through activation of ...
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Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease
... Pgc1α, peroxisome proliferator-activated receptor gamma coactivator 1- alpha; Fasn, fatty acid synthase; Acc, acetyl-CoA carboxylase; Scd1, stearoyl-CoA desaturase; Insig1, ...
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Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator–activated receptor γ activator–mediated inhibition of dendritic cells
... effects. Peroxisome proliferator– activated receptor gamma (PPARγ) is involved in inhibition of inflammatory responses and induction of DCs to acquire a mucosal ...
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The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential
... Safety As with all novel therapies, clinicians and patients alike share concerns regarding benefits versus risks. Across all trials, this SPPARMα agonist was generally well tolerated, particularly with respect to renal ...
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Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism
... thrombin receptor, recent work from the Hollenberg’s labora- tory has demonstrated that thrombin can signal through PAR2 (Mihara et ...that activated PAR2 strongly reduced the proliferation of imma- ture ...
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Protease-activated receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation
... Interestingly, a lack of correlation between the level of these two major cytokines and the level of gut inflammation has been reported in the literature. This is exemplified in the paper of Guiton et al. (4) where the ...
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Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.
... β receptor, MCP-1, CTGF and PAR-1 target genes, and for RLP0 (encoding the human acidic ribosomal phosphoprotein P0, used as a control) are shown in Table ...
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Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model
... ubiquitous receptor present in platelets, endothelial and epithelial cells, neurons, fibroblasts, smooth muscle cells, leukocytes and tumor cell lines ...a receptor involved in many physiological processes ...
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Tissue-specific differential induction of duplicated fatty acid-binding protein genes by the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio)
... analyses must be interpreted cautiously. To illustrate this cautionary point, in silico analysis of the rat peroxisomal thiolase B gene identified a putative PPRE in the pro- moter region of this gene that did not bind ...
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Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain
... Electromyographic activity of abdominal muscle contrac- tions evoked by CRD in mice either 1 h after colorectal infusion of 100 lg PAR-4-AP or its vehicle, or 30 min after PAR-4 antagoni[r] ...
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Activité physique et prévention de l'arthérosclérose : Mise en évidence de l’implication des PPAR (Peroxisome Prolife- raor-Activated Receptor) dans la cardioprotection induite par l’exercice physique soumis ou volontaire chez la souris ApoE-/- mice
... puis se transformer en macrophages. Les macrophages captent les LDL oxydées par l‟intermédiaire de récepteurs (SR-AI, CD-36, CD68) et se transforment en « cellules spumeuses ». Les cellules spumeuses sont à l‟origine de ...
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Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock.
... Recent reports have highlighted the interplay between circadian oscillators, metabolism and physiology. Whereas genes involved in the glucose and lipid metabolism are known to exhibit circadian variations (21-23), ...
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