Peroxisome proliferator-activated receptor γ
Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator–activated receptor γ activator–mediated inhibition of dendritic cells
... PPARγ pathway. Recently, our group isolated two novel eremophilane-type sesquiterpene com- pounds from Petasites tatewakianus Kitam. 2 We hypothesized that these novel sesquiterpenes would inhibit DC maturation and ...
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Peroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A
... hormone receptor signaling (Kitamura et ...by peroxisome proliferator–activated receptor γ (PPARγ), a nuclear hormone receptor whose dysregulation is involved in the onset ...
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A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis
... antitopoisomerase I) and presence/absence of interstitial lung disease and pulmonary hypertension. Abbreviations ACA: anticentromere antibodies; ACR: American College of Rheumatology; ATA: anti-topoisomerase I ...
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Peroxisome proliferator-activated receptor-γ activation induces 11β-hydroxysteroid dehydrogenase type 1 activity in human alternative macrophages.
... were γ α in vitro transcribed from the pSG5-hPPAR and pSG5-hRXR plasmids (Promega, Madison, ...the γ α preparation of nuclear extracts, RM, M1 and M2 macrophages were collected in hypotonic buffer (15mM ...
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Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2.
... being Peroxisome Proliferator-activated Receptor γ (PPARγ), mainly the PPAR γ2 isoform ...PPAR γ activity and adipogenesis is of major interest to understand normal and ...
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Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma.
... The peroxisome proliferator-activated receptor γ (PPARγ), a ligand inducible transcription factor, has been identified as a major regulator of terminal adipocyte differentiation (10, ...
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Placental Implications of Peroxisome Proliferator-Activated Receptors in Gestation and Parturition
... PPAR γ shows the highest conservation in terms of cDNA and ...nuclear receptor su- perfamily, PPARs possess the typical structure organised in six domains named A to F (see Figure 1(b) ) [ 5 ...nuclear ...
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Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease
... and γ agonist saroglitazar, and the pan-PPAR agonist lanifibranor in preclinical models of ...lipoprotein receptor; Cpt, carnitine palmitoyltransferase; Slc27a1, solute carrier family 27 member 1; Fabp, ...
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Distinct Protein Expression Networks are Activated in Microglia Cells after Stimulation with IFN-γ and IL-4
... 3. Results 3.1. IFN-γ and IL-4 Treated CHME-5 Microglia Cells Presented Distinct M1- and M2-Like Phenotypes Microglia are resident immune cells of the central nervous system (CNS) that change/polarize their ...
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Rat protease-activated receptor–1 (rPAR1) expression and characterization in Sf9 cells
... this receptor and coupling to Gα s yields an increase in intracellular calcium through the release of Ca 2+ from intracellular stores ...is activated secondary to intracellular Ca 2+ release from ...
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Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain
... Electromyographic activity of abdominal muscle contrac- tions evoked by CRD in mice either 1 h after colorectal infusion of 100 lg PAR-4-AP or its vehicle, or 30 min after PAR-4 antagoni[r] ...
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Protease-activated receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation
... Abstract Toxoplasma gondii is a widespread intracellular parasite, which naturally enters the organism via the oral route and cross the intestinal barrier to disseminate. In addition to neuronal and ocular pathologies, ...
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Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism
... and/or γ-thrombin. α-Thrombin preferably binds and cleaves PAR1, but γ-thrombin is a much less potent agonist for PAR1 and more potent for PAR4 activation (Nystedt et ...thrombin receptor, recent ...
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Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.
... β receptor, MCP-1, CTGF and PAR-1 target genes, and for RLP0 (encoding the human acidic ribosomal phosphoprotein P0, used as a control) are shown in Table ...
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Tissue-specific differential induction of duplicated fatty acid-binding protein genes by the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio)
... and peroxisome proliferators activate these nuclear receptors, and once activated, these nuclear receptors form heterodimers with retinoic-acid receptors (RAR) or retinoid X receptors (RXR) ...and ...
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Activité physique et prévention de l'arthérosclérose : Mise en évidence de l’implication des PPAR (Peroxisome Prolife- raor-Activated Receptor) dans la cardioprotection induite par l’exercice physique soumis ou volontaire chez la souris ApoE-/- mice
... 87 INTRODUCTION Atherosclerosis (ATS) is the leading cause of morbidity and mortality in developed nations. Atherosclerotic plaque rupture leads to arterial occlusion, myocardial infarction, and stroke. Pla- que rupture ...
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Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock.
... Recent reports have highlighted the interplay between circadian oscillators, metabolism and physiology. Whereas genes involved in the glucose and lipid metabolism are known to exhibit circadian variations (21-23), ...
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Sur la ∇^{γ}-quantification
... Dirac γ sur T p,q Ω, on d´efinit la notion d’´equation des ´etats des tenseurs et l’´equation d’´evolution de Schr¨odinger-Dirac le long d’un champ chronologique T ...
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Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism
... Version preprint Comment citer ce document : Nguyen, C., Coelho, A.-M., Grady, E., Compton, S. J., Wallace , J. L., Hollenberg, M. D., Cenac, N., Garcia Villar, R., Bueno, L., Steinhoff, M., Bunnett, N. W., Vergnolle, ...
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Tachykinin NK1 receptors are involved in proteinase-activated receptor (PAR)-2-mediated colonic inflammation in mice
... Version preprint Comment citer ce document : Cenac, N., Guiard, B., Garcia Villar, R., Fioramonti, J., Bueno, L. (2001). Tachykinin NK1 receptors are involved in proteinase-activated receptor ...
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