p38 Mitogen-Activated Protein Kinases
Rôle du couple Flt3-ligand/Flt3 et de l'activation des "Mitogen-activated protein kinases" p38 dans la dysmégacaryopoïèse des patients atteints de myélofibrose primitive
... 2.5/ Peut-on proposer des approches ciblées sur l’axe Flt3- ligand/Flt3/p38 comme thérapies adjuvantes dans la MFP? Hormis le traitement curatif par greffe allogénique de cellules souches proposé à certains ...
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Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes.
... of protein was loaded for p38 and JNK western blotting, respectively) were diluted in Laemmli buffer and boiled at 95°C for 5 ...The protein complexes were visualized by chemiluminescence using the ...
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Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes
... Most studies have considered chondrocytes as passive bystanders in the pathogenesis of BCP crystal associated OA and CPPD disease. However, in primary OA chondrocytes appear to play a major role in cartilage damage. In ...
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Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors
... p38 mitogen-activated protein kinases (p38 MAPKs) are a family of serine/threonine kinases widely expressed and consisting of four isoforms: p38α, p38β, p38γ and ...p38δ. ...
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Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors
... p38 mitogen-activated protein kinases (p38 MAPKs) are a family of serine/threonine kinases widely expressed and consisting of four isoforms: p38α, p38β, p38γ and ...p38δ. ...
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Knock-down of filaggrin influences the mitogen-activated protein kinases signaling pathway in normal human epidermal keratinocytes
... NF-kB, p38, ERK1/2 and JNK (Figure 3). The phosphorylation levels of p38 protein, ERK1/2 protein, JNK protein, Akt protein and NF-kB protein were decreased significantly ...
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The release of pro-inflammatory cytokines is mediated via mitogen-activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes
... inhibitor selective for the p38 α and β isoforms 14 . Both inhibitors (U0126 and SB239063) significantly reduced the production of IL-8/CXCL8 by HaCaT Cells stimulated with MSU (Figure 5). Gene expression ...
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p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells.: P38 CONTROLS THE MESODERMAL COMMITMENT OF ES CELLS
... dogenous p38 protein levels, between 23% and 46% of levels present in wt cells, at day 4 of differentiation ...MAPK activated protein kinase-2 (MAPKAP-K2) ...MAPKAP-K2 protein is a good ...
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Regulation of ES Cell Lineage Commitment by Mitogen Activated Protein Kinases
... for p38 in various aspects of cardiomyogenesis including the regulation of cardiomyocyte differentiation, apoptosis, and hypertrophy has been described [48-50], and, accordingly, p38 -/- embryos present ...
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Regulation of the hepatocyte cell cycle: signaling pathways and protein kinases.
... The special issue collected ten original research articles and reviews that present an update of various biochemical pathways underlying the cell cycle regulation of the adult hepatocytes. All the articles of this ...
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L’AMP-activated protein kinase hypothalamique, régulateur essentiel du poids et de la prise alimentaire
... L’AMP-activated protein kinase (AMPK), constituée de trois sous-unités (une sous-unité catalytique α 1 ou α 2, deux sous-unités régulatrices β et γ ), est une enzyme ubiquitaire dont l’acti- vité dépend de ...
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Lectin receptor kinases participate in protein-protein interactions to mediate plasma membrane-cell wall adhesions in Arabidopsis.
... recombinant protein appeared as a major band at a molecular mass of 85 kDa ...of protein in lane ...recombinant protein were deposited in each ...of protein were deposited in each ...each ...
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Are the IKKs and IKK-related kinases TBK1 and IKK-ε similarly activated ?
... IkB kinases (IKKs) IKK-a and IKK-b, and the IKK-related kinases TBK1 and IKK-e, have essential roles in innate immunity through signal-induced activation of NF-kB, IRF3 and IRF7, ...kinase-associated ...
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Place de l'AMP-activated protein kinase dans le preconditionnement ischemique renal.
... ß 2013 Association Socie´te´ de ne´phrologie. Publie´ par Elsevier Masson SAS. Tous droits re´serve´s. A B S T R A C T Kidney transplantation represents the best treatment of end-stage renal disease. In addition to the ...
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AMP-activated protein kinase controls liposaccharide-induced hyperpermeability
... Methods Patient data were collected from January 2009 to November 2011. A multidisciplinary algorithm-based protocol was written by our ECLS Team. The va-ECLS indications were bleeding shock, with potential controllable ...
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Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.: Crosstalks between the MAP kinase and Smad pathways
... involvement of p38 kinase activity in TGF- induced several MMP biosynthesis in fibroblasts, breast epithelial cells or in transformed keratinocytes (Johansson et al., 2000; Kim et al., 2004; Kim et al., 2005; ...
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The estrogen effects on endothelial repair and mitogen-activated protein kinase activation are abolished in endothelial nitric-oxide (NO) synthase knockout mice, but not by NO synthase inhibition by N-nitro-L-arginine methyl ester.
... eNOS protein, but not eNOS activity, in the endothelial cells of carotid ...between protein expression and enzymatic activity was nicely demonstrated for PI3Kγ 39 which participates in two distinct ...
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Role of receptor and non-receptor protein tyrosine kinases in vasoactive peptide-induced signaling
... tetrameric protein consisting of 2 α- and 2 β-subunits, and has a high degree of homology with the insulin receptor 382 ...is activated by IGF-1 and associated growth factors, such as IGF-2, albeit with ...
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Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
... calcium-dependent protein kinase (CDPK) family show genetic redundancy during erythrocytic ...among protein kinases in Plasmodium ...the protein kinase G (PKG) and CDPK4 to control erythrocyte ...
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Coordinated maintenance of muscle cell size control by AMP-activated protein kinase.
... and protein degradation in the ...decreased protein synthesis and increased protein degradation in an AMPK-dependant manner in C2C12 myotubes ...myofibrillar protein degradation by increasing ...
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