p38 MAPK
Targeting the p38 MAPK pathway inhibits irinotecan resistance in colon adenocarcinoma.: Activated p38 and chemoresistance
... of p38 enhances the efficacy of irinotecan-based ...that p38 phosphorylation is increased in SN38 resistant clones derived from HCT116 and SW48 cells, suggesting that p38 activation might represent a ...
11
Ascorbic acid drives the differentiation of mesoderm-derived embryonic stem cells. Involvement of p38 MAPK/CREB and SVCT2 transporter
... tion toward myogenesis and osteogenesis and also inhibits adipogenesis. Further experiments found that AA competes with retinoic acid (RA) to drive cell differentiation in a dose-dependent manner: AA inhibited neurogenic ...
14
Combination of metformin and p38 MAPK inhibitor, SB203580, reduced myocardial ischemia/reperfusion injury in non‑obese type 2 diabetic Goto‑Kakizaki rats
... basal p38 MAP Kinase (p38 MAPK) activation in cardiac ...of p38 MAPK activation could be a beneficial and therapeutic type of treatment for diabetic ...
15
A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans
... PMK-1 p38 MAPK pathway transcriptional targets [13], we observed an enrichment for genes regulated by the PMK-1 p38 MAPK pathway among genes downregulated with ...
10
Rôle des MAPK dans la migration des lymphocytes Th17 à travers le collagène tridimensionnel (3D)
... to p38 MAPK and/or DDR1 pathways remain to be ...observed p38 activation in 3D ...through p38 activation [Kim et ...the p38 MAPK pathway in human effector T cells. Inhibition of ...
87
L’amélioration de la performance et de la structure cardiaque par la moxonidine chez les SHR est accompagnée d’une diminution des cytokines, de la MAPK p38 et de l’Akt
... of p38 and Akt in the left ventricle after 1 and 4 weeks treatment, in association with reduced blood pressure and heart ...of p38 MAPK and Akt, and allow us to suggest that besides inhibiting the ...
108
en fr Implication of p38 and p53 in cetuximab mechanism of action in colorectal cancer Implication de p38 et p53 dans le mécanisme d’action du cetuximab dans le cancer colorectal
... activated MAPK p38 as compared with the corresponding parental ...of p38 have been described, we then studied the effect of p38 overexpression or downregulation of each isoform on cell ...
184
Integrative Modelling of the Influence of MAPK Network on Cancer Cell Fate Decision
... The behaviour of our model in the case of FGFR3 activating mutation is depicted in Figure 4b (cf. Text S2 for a complete simulation). We find again the ‘‘p53 versus ERK’’ pattern accounting for the fundamental role of ...
16
Tgfbeta-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves.
... In a previous study from our lab we described structural defects associated with loss of ECM strati fication in heart valves from Scx −/− mice [18] . In this current study we report that valve phenotypes observed in Scx ...
10
P38. More than twenty years of orchid ex situ conservation in Africa and Madagascar
... 7 th International Orchid Conservation Congress Posters P38. More than twenty years of orchid ex situ conservation in Africa and Madagascar Tariq Stévart 1,2,3* , Eric Akouangou 4 , Félix Andriatsiferana 5 , ...
2
Rôle de Gab1 dans l'interconnection entre les voies Ras/MAPK et PI3K en aval du récepteur de l'EGF
... des MAPK va dépendre de la PI3K, une double inhibition par des inhibiteurs de PI3K et de l’EGFR sera nécessaire pour permettre la levée de la résistance aux inhibiteurs de ...
154
Characterization of a MAPK module involved in Arabidopsis response to wounding
... Characterization of a MAPK module involved in Arabidopsis response to wounding 27 observed in potato (Herde et al., 1996) and avocado trees (Oyarce & Gurovich, 2011). WASPs can be transmitted to leaves from a ...
196
Analysis of MAPK and MAPKK gene families in wheat and related Triticeae species
... Abstract Background: The mitogen-activated protein kinase (MAPK) family is involved in signal transduction networks that underpin many different biological processes in plants, ranging from development to biotic ...
27
Feedback regulation of Gab2-dependent signaling by the Ras/MAPK pathway
... 46 prevents cells entering into mitosis by phosphorylating Cdc25, a phosphatase activating the Cdk/cyclins by dephosphorylating Wee1. In melanoma cell lines, hyperactivated N-Ras or B-Raf by mutations lead to ...
210
Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
... including MAPK/ERK signaling, implicated in a spectrum of human pathologies; thus, TrkA is an emerging therapeutic target in treatment of neuronal diseases and ...
12
Characterization of p120-catenin, a novel RSK substrate in the Ras/MAPK signalling pathway
... Finally, a newly emerging function that is of particular importance to my project is the role of RSK in promoting Ras/MAPK-dependent cell motility and invasion. Using pharmacological inhibitors, RSK1 and 2 were ...
103
TERT Promoter Mutation as an Independent Prognostic Marker for Poor Prognosis MAPK Inhibitors-Treated Melanoma
... with MAPK inhibitors: 6 received a monotherapy of BRAF inhibitor (vemurafenib (n = 4) or dabrafenib (n = 2)), 46 received a bitherapy of BRAF and MEK inhibitor (vemurafenib-cobimetinib (n = 4) or ...
16
Régulation de l'expression génique et de la sécrétion des cytokines chez le neutrophile humain : implication de la voie des MAPK MEK/ERK et son découplage
... Hydrogen peroxide induces murine macrophage chemokines gene transcription via extracellular signal-regulated kinase- and cyclic adenosine 5' -mono phosphate ( cAMP)-dependant pathways:[r] ...
130
Anomalies moléculaires de la voie MAPK et cancer papillaire de la thyroïde : étude de deux phosphatases spécifiques de ERK, DUSP5 et DUSP6
... voie MAPK dépend de la présence d’un élément de réponse, très conservé, pour les facteurs de transcription Ets-1 et Ets-2, appartenant à la famille des facteurs de transcription à domaine ETS (E-twenty six) [204, ...
173
In vivo identification of solar radiation-responsive gene network: role of the p38 stress-dependent kinase.
... the p38 stress-responsive pathway was affected, supporting and mediating p53 ...of p38 (SB203580) to investigate genes the expression of which was associated with active p38 ...direct p38 ...
11