nuclear hormone liver X receptor
The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism.
... differences may also underlie this difference because female rats and male mice were used in our studies. Endogenous estrogens can activate both rodent and human CAR [29,30] but only at high concentrations, reached ...
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New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors
... a receptor able to respond to non-canonical agonists like non-androgen ...steroid receptor coactivator (SRC1) [ 117 ], lysine methyltransferase (EZH2) [ 118 ], and aldo-keto-reductase (AKR1C3) [ 119 ...
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Liver X receptors, lipids and their reproductive secrets in the male
... numerous nuclear receptors, called “orphan” since no bona fide ligand had been identified, opened the way of the reverse endocrinology ...its hormone, the nuclear receptor is used to screen ...
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Liver X receptors, lipids and their reproductive secrets in the male
... numerous nuclear receptors, called “orphan” since no bona fide ligand had been identified, opened the way of the reverse endocrinology ...its hormone, the nuclear receptor is used to screen ...
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The orphan nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2) regulates decidualization
... human nuclear receptors and allowed for the classification in six different subfamilies (Robinson-Rechavi, Carpentier et ...the nuclear receptor family, but for which the ligand was yet to be ...
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New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors
... a receptor able to respond to non-canonical agonists like non-androgen ...steroid receptor coactivator (SRC1) [ 117 ], lysine methyltransferase (EZH2) [ 118 ], and aldo-keto-reductase (AKR1C3) [ 119 ...
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Brain volumes in late life: gender, hormone treatment, and estrogen receptor variants.
... All brain measures are given as a percentage of total intracranial volume (ICV), except for the volume of white matter lesions, which were adjusted for the volume of white matter.. Adju[r] ...
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en fr LXRs (Liver X Receptors) involvement during prostate cancer metastatic dissemination Rôle des récepteurs aux oxystérols LXRs (Liver X Receptors) dans la dissémination métastatique du cancer de la prostate
... Liver X Receptors activation in prostate constrains cancer growth and metastasis progression.... Une partie de ces travaux a fait l’objet d’articles en cours de soumission : Alioui A, [r] ...
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Relationships of polymorphisms for growth hormone and growth hormone receptor genes with milk production traits for Italian Holstein-Friesian bulls
... This possibility prompted us to investigate the eventual relationships of restriction fragment length polymor- phisms a t the locus of bovine growth hormone (using Tag1 [r] ...
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Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study.
... of hormone receptor status data, and we thank all the EPIC cohort participants for their contributions to data collection at baseline recruitment and during ...
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Rôle du Liver X Receptor dans la régulation transcriptionnelle de la lipogenèse
... glucocorticoid receptor » (GR) (Weitzel, Stark et ...activated receptor α » (PPARα) inhibent la synthèse des acides biliaires et facilitent la sécrétion de phospholipides dans la bile, limitant ainsi la ...
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Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.
... the liver microsomal metabolism of CCl 4 leading to the generation of the toxic trichloromethyl radical that induce hepatocyte necrosis and apoptosis ...of liver necrosis as quantified by ...the ...
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Aryl Hydrocarbon Receptor-Dependent Induction of Liver Fibrosis by Dioxin
... TCDD increases the expression of the hepatic fibrosis markers Coll1A1 and α-SMA and leads to hepatic fibrosis. A Wild-type mice were treated on days 0 and 7 with either TCDD (25µg/kg) or corn oil (control) and ...
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Defects in the C. elegans acyl-CoA Synthase, acs-3, and Nuclear Hormone Receptor, nhr-25, Cause Sensitivity to Distinct, but Overlapping Stresses
... the nuclear hormone receptor nhr-25 ameliorates developmental and metabolic phenotypes associated with loss of function of an acyl-CoA synthetase gene, ...
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Hormone treatment, estrogen receptor polymorphisms and mortality: a prospective cohort study.
... Strengths and limitations of the study Limitations to this study include the 6-year follow-up and small number of deaths which was insufficient to examine in detail specific causes of mortality such as ...
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Régulation du récepteur nucléaire Farnesoid X Receptor par la voie de biosynthèse des hexosamines
... 1.2.4.4.Activation function-2 ou AF-2 Le domaine AF-2 (Activation function-2), hautement conservé entre les RNs, joue un rôle important dans l’activité transcriptionnelle des RNs via sa capacité à interagir avec les ...
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Les "Liver X Receptors" : modulateurs des fonctions des cellules dendritiques plasmocytoïdes et leur contrepartie leucémique
... /DXULH G¶OD FRP PD S¶WLWH ELFKHWWH OpRQRUH HW $GHOLQH PHV H[ FRORF SRXU OH PHLOOHXU FRPPH SRXU OH SLUH %HDXFRXS GH PHLOOHXU TXDQG PrPH *HRIIUH\OHS¶WLWFRTDOHFKDPSOLEUHIRQFHPRQSRXOHWDYDQWT[r] ...
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Control of nuclear receptor activities in metabolism by post-translational modifications.
... orphan receptor subclass which also includes Nor1 and ...antigen receptor-mediated cell death [106], but is now known to regulate hepatic glucose [107] and lipid homeostasis ...
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The role of the nuclear receptor Nr5a2 in ovulation in mice
... 5. Discussion Cumulus cells create a microenvironment conducive for oocyte growth and development that is necessary for ovulation and fertilization (Brower and Schultz 1982). Successful fertilization is correlated with ...
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The beta secretase BACE1 regulates the expression of insulin receptor in the liver
... of liver- specific IR knockout mice validate the role of BACE1 in the cleavage of IR in vivo and indicate that the liver contributes significantly to IRsol plasma ...from liver explants is reduced by ...
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