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nonsense-mediated mRNA decay

Premature termination codons in SOD1 causing Amyotrophic Lateral Sclerosis are predicted to escape the nonsense-mediated mRNA decay

Premature termination codons in SOD1 causing Amyotrophic Lateral Sclerosis are predicted to escape the nonsense-mediated mRNA decay

... . Nonsense-mediated mRNA decay (NMD) is an eukaryotic quality control pathway that degrades mRNAs containing Premature termination codons (PTCs) caused by nonsense or frameshift ...

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The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD)

The Complex Relationship between HTLV-1 and Nonsense-Mediated mRNA Decay (NMD)

... generated nonsense mutations in the viral genome that enable HTLV-1-infected cells to escape from the host immune system in ATL ...an mRNA decay pathway depending on the translation like the NMD ...

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Divergent effects of translation termination factor eRF3A and nonsense-mediated mRNA decay factor UPF1 on the expression of uORF carrying mRNAs and ribosome protein genes

Divergent effects of translation termination factor eRF3A and nonsense-mediated mRNA decay factor UPF1 on the expression of uORF carrying mRNAs and ribosome protein genes

... in mRNA levels and translational control on transcriptional regulators provides for versatility in regulating gene expression ...the mRNA landscape, although these actions might be largely ...

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Identification d’inhibiteurs du nonsense-mediated mRNA decay (NMD) et utilisation comme approche thérapeutique dans certaines maladies génétiques

Identification d’inhibiteurs du nonsense-mediated mRNA decay (NMD) et utilisation comme approche thérapeutique dans certaines maladies génétiques

... De plus, une étude chez la levure a montré que le decapping de l’ARNm peut être initié de façon co-traductionnelle lorsqu’il est encore associé au ribosome dans les fractions polysomal[r] ...

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Composition et dynamique des complexes protéiques impliqués dans le "nonsense-mediated mRNA decay" chez la levure Saccharomyces cerevisiae

Composition et dynamique des complexes protéiques impliqués dans le "nonsense-mediated mRNA decay" chez la levure Saccharomyces cerevisiae

... To establish how NMD4 and EBS1 could affect NMD substrates, we searched for conditions that would simplify our phenotypic analysis. We chose to focus on the helicase and C- terminal domain of Upf1, important for binding ...

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Inactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae.

Inactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae.

... of nonsense suppression at termination codons in a variety of yeast genes (reviewed in ...and nonsense-mediated mRNA decay, sug- gesting that GTP/eRF3-dependent termination exerts its ...

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Nonsense-Mediated Decay Restricts LncRNA Levels in Yeast Unless Blocked by Double-Stranded RNA Structure

Nonsense-Mediated Decay Restricts LncRNA Levels in Yeast Unless Blocked by Double-Stranded RNA Structure

... unwinding mRNA/asXUTs duplexes is further supported by the analysis of CRAC data ( Tuck and Tollervey, 2013 ) showing that Mtr4 binds to the 5 0 region of mRNAs that form dsRNAs with asXUTs, while its binding to ...

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Cytoplasmic Control of Sense-Antisense mRNA Pairs

Cytoplasmic Control of Sense-Antisense mRNA Pairs

... these mRNA-mRNA interactions in wild-type cells was demonstrated by the fact that the presence of the OCA2 mRNA interferes with 3 0 –5 0 mRNA degradation of the POR1 mRNA and leads to ...

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On decay constants and orbital distance to the Sun. Part I: alpha decay

On decay constants and orbital distance to the Sun. Part I: alpha decay

... [25] which has implications for cosmochronology. As much as these claims attract interest as inspiration for new physical theories or hope for revolutionising cosmic neu- trino detection and radioactive waste management ...

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Dissemination and visualisation of reference decay data from Decay Data Evaluation Project (DDEP)

Dissemination and visualisation of reference decay data from Decay Data Evaluation Project (DDEP)

... 2. Data evaluation New or updated nuclide evaluations are regularly added to the N UCL EIDE ´ database through the work of evaluators from the Decay Data Evaluation Project (DDEP) [ 1 ]. These evaluations are ...

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The Decay Data Evaluation Project (DDEP) and the JEFF-3.3 radioactive decay data library: Combining international collaborative efforts on evaluated decay data

The Decay Data Evaluation Project (DDEP) and the JEFF-3.3 radioactive decay data library: Combining international collaborative efforts on evaluated decay data

... The initial decay heat benchmarking of JEFF-3.1, along with the work of the OECD/NEA Working Party on International Evaluation Co-operation sub- group 25 (WPEC-25) [ 7 ] highlighted some problems in the individual ...

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On decay constants and orbital distance to the Sun—part I: alpha decay

On decay constants and orbital distance to the Sun—part I: alpha decay

... the decay constants of radi- onuclides decaying by α, β − and β + emission has withstood many experimental tests, showing independence to physical and chemical conditions such as temperature, pressure, and ...

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An mRNA-mRNA Interaction Couples Expression of a Virulence Factor and Its Chaperone in Listeria monocytogenes

An mRNA-mRNA Interaction Couples Expression of a Virulence Factor and Its Chaperone in Listeria monocytogenes

... selected mRNA demonstrated that binding of the 30S ribo- some subunit confers DMS protection for the nucleotides of the SD sequence ( H€uttenhofer and Noller, 1994 ...

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On decay constants and orbital distance to the Sun—part II: beta minus decay

On decay constants and orbital distance to the Sun—part II: beta minus decay

... non-exponential decay. However, also the conjecture that cosmic neutrinos stimulate decay has been further developed: Sturrock et al [ 20 ] found arguments to claim that there is a directional relationship ...

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Algorithms for simulating human pre-mRNA splicing decisions

Algorithms for simulating human pre-mRNA splicing decisions

... With a high cutoff, only high-scoring exons will be predicted. These exons are likely to be correct; however, the simulation will tend to miss low- and medium- sc[r] ...

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CUORE sensitivity to 0νββ decay

CUORE sensitivity to 0νββ decay

... use of different algorithms, e.g. nested sampling [ 35 , 36 ], or a partial analytical solution of the likelihood maximization. We perform two further cross-checks in order to investi- gate the relative importance of the ...

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CUORE sensitivity to 0νββ decay

CUORE sensitivity to 0νββ decay

... – E represents the data. It is a list of N energy bins cen- tered at the energy E i and containing n i event counts. The energy range is [2470; 2570] keV. This is the same range used for the CUORE-0 0 νββ decay ...

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Angular analysis of the decay

Angular analysis of the decay

... the decay rate for the B þ → K þ μ þ μ − process: the forward-backward asymmetry A FB of the dimuon system and the contribution F H from the pseudoscalar, scalar, and tensor amplitudes to the decay ...the ...

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Environmentally Mediated Social Dilemmas

Environmentally Mediated Social Dilemmas

... At present, theoretical work on environmentally-mediated social interactions has largely focused on simple non-spatial settings (except, notably, work on biofilms; e.g, [13-17]), while the broader field of social ...

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Mécanismes modulant l'épissage alternatif du pré-mRNA de la NCAM murine

Mécanismes modulant l'épissage alternatif du pré-mRNA de la NCAM murine

... L'élément exonique que nous avons identifié est situé dans un exon constitutif (El 7) et influence les profils d'épissage d'un exon alternatif adjacent (El8). Cette influence sur l'[r] ...

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