Nonalcoholic fatty liver disease (NAFLD)
Nonalcoholic fatty liver disease and obstructive sleep apnea
... of nonalcoholic fatty liver disease ...exacerbating liver oxidative stress. OSA also disrupts the gut liver axis, increasing intestinal permeability and with a possible role of ...
28
Dihydroceramides in Triglyceride-Enriched VLDL Are Associated with Nonalcoholic Fatty Liver Disease Severity in Type 2 Diabetes
... patients. Liver biopsies from subjects with suspected non-alcoholic fatty liver disease are analyzed for sphingolipid synthesis enzyme ...with nonalcoholic fatty liver ...
17
Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?
... Available NAFLD therapeutic option are scare apart from efficient weight-loss, which is not easily achieved by all patients even in RCT, let alone in real life. Since GM is involved in NAFLD pathogenesis, targeting the ...
38
Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.
... the liver [28-30] ...in nonalcoholic steatohepatitis (NASH) [32] . Indeed, this liver lesion is associated with significant impairment of the respiratory chain activity, which greatly favors the ...
15
Magnetic resonance-based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
... MRE liver stiffness reduction higher than 15% is observed in patient with BMI reduction of 5% over 24 weeks in a setting of a clinical ...paired liver biopsy. 61 This study has reported that the reduction ...
10
Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?
... self-limiting disease of the upper airways, called coronavirus disease 2019 (COVID- 19), which may result in intensive care unit (ICU) admission and fatalities ...dysfunction-associated fatty ...
32
View of Non Alcoholic Fatty Liver Disease and Non Alcoholic Steato-Hepatitis are Multisystemic Diseases: Review for Intensivists
... With Nonalcoholic Stea- tohepatitis [NASH] [RESOLVE-IT] ; NCT02704403) et per- mettra d ’asseoir ou non ces résultats qui sont discutés du fait du retraitement ...
12
Specificities of Human Hepatocellular Carcinoma Developed on Non-Alcoholic Fatty Liver Disease in Absence of Cirrhosis Revealed by Tissue Extracts 1H-NMR Spectroscopy
... HCC was diagnosed before surgery using either radiological Barcelona criteria or liver biopsy histological analysis [ 34 ]. Diagnosis was established after surgery using pathological analysis. We did not include ...
18
Elevated serum liver-type fatty acid binding protein levels in non-acetaminophen acute liver failure patients with organ dysfunction.
... drug-induced liver injury (DILI) with serial samples, n=141 patients were selected at random by personnel not involved in the analysis of the samples or statistical analysis for the ...were liver transplant ...
13
Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials
... microbiota ecosystems 19 44 87 115 119 and, in particular, short chain fatty acid production. 121 It is reasonable to antici- pate that these multiple effects may combine to induce significant effects, ...
13
Autochthonous liver cystic hydatid: Past or actual French shepherd's disease?
... albendazole chemotherapy or ‘watch & wait ’ (WW). Our patient presented with 3 cysts, two classi fied CE5 and one CE3b. Conventionally, WW is appropriate for uncomplicated inactive CE5 cyst [ 14 ], whereas management ...
4
SERPINA1 Z allele is associated with cystic fibrosis liver disease
... Methods: The associations of SERPINA1 Z (rs28929474) and S (rs17580) alleles with age at CFLD onset and the development of CFLD-related complications (severe liver disease with cirrhosis, portal ...
25
Specificities of Hepatocellular Carcinoma Developed on Non Alcoholic Fatty Liver Disease in Absence of Cirrhosis Revealed by Tissue 1H-NMR Spectroscopy
... 3. RESULTS Tissue spectra of HCC and NTT groups were separated by OPLS-DA with aqueous extract data and lipid extract data (Fig.1 A and C). Multivariate analysis showed that HCC tissue is characterized by high level of ...
2
Nutrigenomics of high fat diet induced obesity in mice suggests relationships between susceptibility to fatty liver disease and the proteasome
... measures, liver histology, hepatic lipid measurements and liver genome-wide gene transcription profiling in C57BL/6J and BALB/c mice fed either a control or a high fat ...alcoholic fatty liver ...
13
Brain edema in acute liver failure and chronic liver disease: Similarities and differences
... Parkinson’s disease (Song et ...Wilson’s disease demonstrated that Alzheimer type II astrocytes originate from the fibrous type of astroglia (Bertrand et ...
20
Tight junction proteins in gastrointestinal and liver disease
... expression of tight junction adhesion proteins in cancer pathogenesis. Claudins: multifunctional players in epithelial tight 1142[r] ...
61
AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development
... stimulated fatty acid oxidation to various ...increased fatty acid oxidation to levels similar to those achieved with the ACC inhibitor TOFA, whereas the small-molecules A-769662 and 991 had a weaker ef- ...
17
DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease
... on fatty liver could be explained by the downregulation of SREBP-1 processing, suggesting that DEPTOR reduces SREBP-1 activity possibly by repressing ...with liver- specific knockout of SCAP, the ...
31
Awareness of the severity of liver disease re-examined using software-combined biomarkers of liver fibrosis and necroinflammatory activity
... Figure 1 Awareness of liver fibrosis according to the FibroTest in USA, France and in other countries. First column (main characteristics): number of subjects, median age, percentage of women and of subjects with ...
12
Rôle du régulateur du cycle cellulaire p16INK4a dans le développement du diabète de type 2 et dans les maladies métaboliques du foie gras ou NAFLD (Non-Alcoholic Fatty Liver Disease) : rôle de p16INK4a dans le contrôle de la néoglucogenèse hépatique et dans le développement de la stéatose hépatique non alcoolique.
... 58 Au niveau de la gouttelette lipidique cytosolique, l’ATGL qui hydrolyse les TG en DG, n’est pas associée à la sécrétion des VLDL mais oriente plutôt les AG vers la β-oxydation (165,166). L’expression d’ATGL est ...
117