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NLRP3 inflammasome

The purinergic p2x7 receptor-nlrp3 inflammasome pathway: A new target in alcoholic liver disease?

The purinergic p2x7 receptor-nlrp3 inflammasome pathway: A new target in alcoholic liver disease?

... the NLRP3 inflammasome by inhibiting the function of the cytosolic glycolytic enzyme hexokinase [ 74 ...cytoplasmic NLRP3 inflammasomes, resulting in IL-1β gene transcription and IL-1β secretion in ...

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Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation

... Nlrp3 inflammasome. 7,8,20,22 Thus, it has been suggested that the inflammasome works as a sensor of cellular membrane disruption characterized by a loss of intracellular ...triggers Nlrp3 ...

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Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation

... to Nlrp3 inflammasome activation in human ...that Nlrp3 inflammasome activation occurs via lysosomal ...activate Nlrp3 inflammasome, recalling the inflammation caused by asbestos ...

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Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation

Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation

... the inflammasome genes, adapt to their surrounding microenviron- ment by a phenotypic polarization towards a pro-inflammatory M1 phenotype that promotes inflammation or an anti-inflammatory M2 phenotype important ...

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The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.

... cells on cytospin preparations (Shandon CytoSpin 3, Thermo Scientific, Illkirch, Figure 9 Schematic diagram illustrating the specific cascade and signalling pathway in LPS-primed macrophages stimulated with ...

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en fr Involvement of purinergic receptors in NLRP3-inflammasome pathway from macrophages Implication des récepteurs purinergiques dans l'activation de l'inflammasome NLRP3 dans les macrophages

... Inflammasome factor and pro-inflammatory cytokine mRNAs expression MSU crystals trigger the activation of the established signaling pathway from TLR2, TLR4 and CD14 receptors to induce NF- B signaling pathway ...

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Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

... expressed NLRP3 and vice versa ...mouse NLRP3 in cells coexpressing constitutively active PKD1 (PKD1ca; ...of NLRP3 lacking the pyrin domain, the nucleotide-binding domain (NBD) or the leucine-rich ...

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S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-kappaB(1.)

S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-kappaB(1.)

... the NLRP3 inflammasome by NF-kB-driven protein synthesis stim- ulated by LPS ...the inflammasome has been previously linked to several immune and non-immune diseases ...or NLRP3 [63–65]. ...

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NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

... different NLRP3 activators, it is unlikely that each of them binds directly to the in ...for NLRP3 in flammasome ...many NLRP3 activa- tors tested to date [44 , 55 , 56] ...by NLRP3 activators ...

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en fr L’inflammasome NLRP3 : physiopathologie et application thérapeutique [The NLRP3 inflammasome: Physiopathology and therapeutic application] L’inflammasome NLRP3 : physiopathologie et application thérapeutique

... hépatocytes, comme la protéine C réactive (CRP). L’IL-1β induit également la synthèse de chimiokines et de molécules d’adhérence par les cellules endothéliales entrainant ainsi le recrutement des leucocytes ou le ...

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Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages

... increasing concentrations of glucose (0–4 g/L) or supplemented with the glucose analogue 2- DG, an inhibitor of glycolysis. Both glucose deprivation and glycolysis inhibition drastically decreased IL-1 β production by ...

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The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes

... of inflammasome agonists: (c) SeV (18 h), (d) ATP (45 min), (e) nigericin (30 min), (f) Alum (5 ...of inflammasome protein levels in lysates from LPS-primed immortalized ...of NLRP3 15 minutes after ...

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Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

... the inflammasome was ...by inflammasome activation (Fig- ure S1G), suggesting bidirectional regulation of these ...in inflammasome-stimu- lated ...

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en fr Study of NLRP3 in MDSC and CD4+ T cells in cancer Etude de NLRP3 dans les cellules myéloïdes immunosuppressives et les lymphocytes TCD4 dans un contexte de cancer

... the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1b (IL-1b), which curtails anticancer ...to Nlrp3 and drove caspase-1 ...in Nlrp3 −/− or Casp1 −/− ...

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NLRP3 controls ATM activation in response to DNA damage

NLRP3 controls ATM activation in response to DNA damage

... (A) Protein levels of the NLRP3 inflammasome components NLRP3, caspase-1 and ASC were 658. assessed by immunoblotting and (B) relative NLRP3 mRNA by Q-RT-PCR in HBEC3-KT cells 659[r] ...

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The release of pro-inflammatory cytokines is mediated via mitogen-activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes

The release of pro-inflammatory cytokines is mediated via mitogen-activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes

... the inflammasome in keratinocytes. Several inflammasome pathways have been described, including the canonical pathway which consists of three main effectors, namely NLRP3, the pro-caspase-1 and the ...

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NLRP3, un inflammasome sous contrôle

NLRP3, un inflammasome sous contrôle

... the NLRP3 inflammasome The innate immunity constitutes an efficient barrier by rapidly detecting pathogens and tissue damages through pattern recognition receptors including ...inappropriate NLRP3 ...

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Human Amnion Epithelial Cells (AECs) Respond to the FSL-1 Lipopeptide by Engaging the NLRP7 Inflammasome

Human Amnion Epithelial Cells (AECs) Respond to the FSL-1 Lipopeptide by Engaging the NLRP7 Inflammasome

... FIGURE 1 | Protein expression level of NLRP7 inflammasome actors in term fetal membranes. Protein expression of ASC (A–C), caspase-1 (D–F), and NLRP7 (G–I) was measured in term amnions and choriodeciduas with or ...

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en fr Role of the inflammasome and of Styk1 kinase in the regulation of cytotoxic lymphocytes Étude du rôle de l’inflammasome et de la kinase Styk1 dans la régulation des lymphocytes cytotoxiques

... Les mutations activatrices de plusieurs récepteurs de l’inflammasome, un complexe multiprotéique senseur de l’immunité innée, sont responsables de divers désordres auto-inflammatoires [54-60]. Comme mentionné en ...

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