Neutralizing antibody
Enhanced Neutralizing Antibody Titers and Th1 Polarization from a Novel Escherichia coli Derived Pandemic Influenza Vaccine
... and Antibody Neutralization Assay Male and female ferrets, aged 4 to 6 months old, were obtained from Marshall Farms (North Rose, ...42. Neutralizing antibody titers against pH1N1 were quantified by ...
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Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
... potent antibody responses targeting conserved ...potent neutralizing antibodies that emerge from natural infec- tion, but these specificities are generally subdominant ...focus antibody responses on ...
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Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01
... The germline VH and VL gene usage of MPER bnAbs shows similarities and differences. 10E8 and DH511 use the germline V gene IGHV3-15, and 4E10 and VRC42 employ IGHV1-69, while LN01 uses yet another one, IGHV4-39, hence ...
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Structural Basis for Broad HIV-1 Neutralization by a Novel MPER-Specific Human Broadly Neutralizing Antibody
... The germline VH and VL gene usage of MPER bnAbs shows similarities and differences. 10E8 and DH511 use the germline V gene IGHV3-15, and 4E10 and VRC42 employ IGHV1-69, while LN01 uses yet another one, IGHV4-39, hence ...
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Dengue Mosaic Vaccines Enhance Cellular Immunity and Expand the Breadth of Neutralizing Antibody Against All Four Serotypes of Dengue Viruses in Mice
... DISCUSSION Stimulating potent immune responses against DENV1 and DENV2 serotypes has been a challenge in Dengvaxia development. Although Dengvaxia confers good protection against DENV3 and DENV4, protection against DENV2 ...
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en fr Study of the neutralizing antibody response against the hepatitis C virus Etude de la réponse humorale neutralisante contre le Virus de l’Hépatite C
... Dans un premier temps nous avons étudié l inhibition de l entrée et la capacité de neutralisation in vitro de l anticorps D Pour cela nous avons développé un test de cell b[r] ...
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Circulating CXCR5[superscript +]CXCR3[superscript +]PD-1[superscript lo] Tfh-like cells in HIV-1 controllers with neutralizing antibody breadth
... expression profile of immunoregulatory receptors (46), and with enhanced abilities for HIV sensing and innate immune recognition (47). However, the impact of dendritic cells from these patients on Tfh development is ...
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IgA dominates the early neutralizing antibody response to SARS-CoV-2
... serum-specific antibody ti- ters (Figure S5H), suggesting that a part of the SARS-CoV-2 antibody response is generated ...SARS-CoV-2 neutralizing IgG (41, 42) did not carry somatic mutations ...
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HCV entry and neutralizing antibodies: lessons from viral variants.
... and neutralizing antibodies, a recent study demonstrated that a HCV variant isolated from a well characterized patient with chronic HCV infection, and located outside the CD81 binding region of E2, was ...
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Neutralizing antibodies in hepatitis C virus infection.
... the neutralizing antibody response during acute and chronic HCV infection using HCV model systems demonstrated a lack of neutralizing antibodies in the majority of patients with acute HCV infection ...
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Antibody-guided vaccine design : identification of protective epitopes
... 17. Swanson KA, Settembre EC, Shaw CA, Dey AK, Rappuoli R, Mandl CW, Dormitzer PR, Carfi A: Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high ...
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Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies
... broadly neutralizing anti- MPER ...broadly neutralizing antibodies can block final steps of refolding of the fusion peptide and the transmembrane region, which is required for completing membrane ...
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Antibody evasion by a gammaherpesvirus o-glycan shield.
... induce neutralizing antibody responses ...viral antibody evasion. In other viruses, most protection against antibody seems to involve N-linked glycans ...in antibody evasion (Figure ...
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Determining the Phagocytic Activity of Clinical Antibody Samples
... clinical antibody samples by utilizing a monocytic cell line long utilized to study phagocytic processes 10 and plate based automated flow ...antigen-specific antibody subsets, allowing not only for study ...
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Antibody-Based Strategies to Prevent and Treat Influenza
... recently, antibody-based strategies to combat infectious agents have been hampered due to the fact that most antibodies have been found to be strain specific, with the virus evolving resistance in many ...broadly ...
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Assisted design of antibody and protein therapeutics (ADAPT)
... in antibody sequence opti- mization is prioritizing the sequence space resulting from the combinatorial explosion when mutating multiple sites in complementarity determining region (CDR) ...
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Antibody drug discovery: From Idea to Biotherapeutic Molecule
... 'proce[f. From diLuTu[jor]with upper managemrent and certain group members it is dear that, while this is somewhat the case, it is possible to abstract these experimental steps into [r] ...
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Single-domain antibody fragments with high conformational stability.
... surface, which interacts with the V L in conventional anti- bodies, are substituted by more hydrophilic amino acids. The single-domain V H H antibody fragments display unique properties (Muyldermans and Lauwereys ...
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Binding symmetry and surface flexibility mediate antibody self-association
... 3(e)), which further suggests self-assembly between native-like folded monomers and not via an unfolding pathway. 4 Fab dimers display symmetric geometries In order to gain an atomic-level understanding of Fab dimeriza- ...
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Ross River Virus Antibody Prevalence, Fiji Islands, 2013–2015
... A serosurvey conducted after the RRV outbreak in Fiji in 1979 detected RRV antibodies in 92% of the participants from the Western division (2). In our study, which was conducted in 2013, RRV antibody prevalence in ...
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