Natural Killer T cells
Invariant natural killer T cells and TGF-ß attenuate anti-GBM glomerulonephritis
... Invariant Natural Killer T Cells and TGF-  Attenuate Anti-GBM Glomerulonephritis Laurent Mesnard,* † Alexandre D.C. Keller, ‡§ Marie-Laure Michel, ‡ Sophie Vandermeersch,* Ce´dric Rafat,* † ...
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Regulatory role of natural killer T cells in diabetes
... Invariant natural killer T (iNKT) cells are innate-like T cells that recognize glycolipids presented by ...These cells not only play a key role in the defense against pathogens, but ...
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Natural killer cells promote early CD8 T cell responses against cytomegalovirus
... NK cells from BALB/c and other strains of mice lacking the Ly49H gene are strongly activated for the acquisition of the cytotoxic machinery and for the produc- tion of IFN-c early after MCMV infection, they fail ...
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Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C.: NK cells in chronic hepatitis C and hepatitis B
... evade natural killer (NK) cell effector functions illustrate the central role for these cells in early host defense against viral infections [2, ...
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Control of acute dengue virus infection by natural killer cells
... of natural killer (NK) cells in DENV ...NK cells and viral pathogenesis has improved significantly. NK cells express an array of inhibitory and activating receptors that enable them to ...
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Increased Degranulation of Natural Killer Cells during Acute HCV Correlates with the Magnitude of Virus-specific T cell Responses
... 3). Natural killer (NK) cells are the most important effector population of the innate immune ...NK cells provide an early defense line against viral infections by killing infected ...
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Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury
... the natural killer (NK) cell receptor NKG2D, Retinoic Acid Early 1 (RAE1), is re-expressed in adult dorsal root ganglion neurons following peripheral nerve injury, triggering selective degeneration of ...
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Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19
... of Natural Killer (NK) cells in antiviral immune responses, 2 we analyzed NK cells in blood from a cohort of 82 individuals: 10 healthy controls (HC), 10 paucisymp- tomatic COVID-19 patients ...
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The role of natural killer cells in sepsis
... immunointerventions. Natural killer (NK) cells are characterized as CD3 − NKp46 + CD56 + cells that can be cytotoxic and/or produce high amounts of cytokines such as IFN- ...NK cells ...
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Manufacturing Natural Killer Cells as Medicinal Products
... Natural Killer (NK) cells are innate lymphoid cells (ILC) with cytotoxic and regulatory ...NK cells thus offer unique opportunities for new and improved therapeutic manipulation, either ...
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Natural killer cells modulation in hematological malignancies
... malignancies, natural killer cells, natural cytotoxicity receptors, immune escape, immunotherapy INTRODUCTION The natural killer (NK) cells are central players in innate ...
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Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules
... ABSTRACT Natural killer (NK) cells play a protective role against dengue virus (DENV) infection, but the cellular and molecular mechanisms are not fully ...NK cells, through the secretion of ...
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OA031-05. HIV escape from natural killer cytotoxicity: Nef inhibits NKp44L expression on HIV-infected CD4+ T cells
... NKp44L+CD4+ cells are highly sensitive to the NK lysis ...HIV-infected cells are resistant to NK killing, suggesting that HIV-1 develop escape mechanisms to counteract NK cytotoxic- ...
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Natural Killer Cells and Pre-B Acute Lymphoblastic Leukemia : Evidence for an Unconventional Cytotoxicity Pathway
... NK cells respec@vely considered as immunoregulatory (in link to cytokine produc@on) and cytotoxic cell subpopula@ons, was queried by inves@ga@ng the kine@cs of their effector ...NK cells had been rou@nely ...
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Unconventional Repertoire Profile Is Imprinted during Acute Chikungunya Infection for Natural Killer Cells Polarization toward Cytotoxicity
... NK cells that coexpress CD94/NKG2C and inhibitory receptors for HLA-C1 alleles and are correlated with the viral ...NK cells in the absence of exogenous signals and severely impaired IFN-c ...NK ...
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Transient Complement Inhibition Promotes a Tumor-Specific Immune Response through the Implication of Natural Killer Cells
... inhibition of complement increased NK cell numbers in spleen and tumor leading to the.. 68.[r] ...
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ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity
... Melanoma cells were transfected with siRNA control or 2 different siRNA directed against ...to cells and acquisition using Incucyte was ...melanoma cells death is displayed for each ...melanoma ...
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High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors
... positive cells were identified using the 20d5 clone which also recognizes NKG2C and NKG2E, however, since mouse resting NK cells only express NKG2A, we considered 20d5 reactive cells as NKG2A ...
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Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer.
... In conclusion, the results of our study demonstrate that anti- CD137 mAbs can enhance trastuzumab’s activity by stimulat- ing the immune response to trastuzumab-bound, HER2-over- expressing breast cancer in vitro and in ...
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Naturally improving the natural cytotoxicity of natural killer (NK) cells
... tumor cells even after releasing KIR ...NK cells include the use of lenalidomide [LEN; ( 20 , 21 ...NK cells, which recognize and kill tumor cells, but are unable to control the disease ( 21 , ...
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