naive cD4 T-cells
IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity
... within naive CD4 T-cells may result from the maturation process that RTEs undergo in the periphery, which may vary throughout life ( 64 – 66 ...that cells with privileged response to IL-7 are ...
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Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4 + T cells
... protein was used (Figure 4E), thus pointing to a specific role of Tmem176a/b in antigen processing 13.. before peptide-MHC II complex display at the surface.[r] ...
49
DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation
... modulates CD4 + Foxp3 + Treg cell activity To identify the function of DEPTOR in CD4 + Tregs, we examined its effects on the epigenetic regulation of Foxp3 transcriptional ...iDEP CD4 + Foxp3 + Tregs ...
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IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection.
... Splenic CD4 T Cells during Chronic VL We have previously reported that IRF-5 mRNA is expressed in splenic T cells in ...T cells are not functional ( Hammami et ...on CD4 T cells. ...
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A critical regulatory role for the cytoplasmic domain of CD28 in ligand binding in naive T cells
... of naive CD4 + T cells from the CD28-tailless mutant knock-in (CD28TL KI; C57BL6/J (Cd28 TL/TL )) mice with COS-A k /B7-1 cells was ...T cells, which mature normally in vivo as those ...
5
Role of CD4+ T cells in the regulation of the immune response against encapsulated Group B Streptococcus
... the autocrine activity of IFN-‐γ (177). Up-‐ regulation of IL-‐12R leads to its increased activation as it binds IL-‐12 in the surrounding environment further reinforcing Th1 differentiation (126). IL-‐12 ...
153
TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells
... The origin of the prolonged decay time currently is unknown. One possible cause is because of the existence of constrained diffusions of intracellular Ca 2+ ions due to spatial confinements for local and specific ...
13
Beta 2-adrenergic stimulation of dendritic cells favors IL-10 secretion by CD4(+) T cells
... on CD4 + T cell activation by DCs in an antigen- specific ...dendritic cells) despite recent controversies ...antigen-specific CD4 + T cells in ...in CD4 + T cell polarization in vivo ...
7
Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells
... B cells that have point mutations introduced into the Ag-binding regions of their B-cell receptor genes by the process of somatic hypermuta- ...B cells are then subjected to selection, and often further ...
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Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients.
... focused on the analyses of transmitted drug resistance and HIV-1 subtype distribution in Europe [5,6]. A standard- ized sampling strategy was designed by the epidemiology expert group of the SPREAD programme to ensure ...
13
ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4+T cells by plasmacytoid dendritic cells
... www.landesbioscience.com OncoImmunology e23185-1 OncoImmunology 2:3, e23185; March 2013; © 2013 Landes Bioscience AuthOr’s VIew AuthOr’s VIew Breast cancer is one of the main causes of death among women in Western ...
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Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.
... Treg cells in vitro during the differentiation process or on fully differentiated Th1 and Th17 cells still remains to be ...functional CD4 + CD25 + Foxp3 + Treg cells under Th1 and Th17 ...
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en fr TO STUDY THE ROLE OF CD4+ SAMHD1low MEMORY CELLS IN HIV-1 INFECTION Caractérisation et rôle des lymphocytes T CD4+ mémoires SAMHD1low au cours de l'infection par le VIH-1
... receptor CD4 and the membrane-spanning co-receptor CC-chemokine receptor 5 (CCR5) (step 1), leading to fusion of the viral and cellular membranes and entry of the viral particle into the cell (step ...
312
HIV‐1 Vpr inhibits autophagy during the early steps of infection of CD4 T cells
... of many cellular proteins (Greenwood et al., 2019), we cannot exclude a role of other transcriptional factors in Vpr-mediated inhibition of autophagy. FOXO3a is regulated by various post-translational modifications ...
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CD32+CD4+ T Cells Are Highly Enriched for HIV DNA and Can Support Transcriptional Latency
... sorted CD4 + T cell fractions, or culture supernatants using the Boom isolation method (Boom et ...lysed cells or extracellular lysates prior to the silica binding ...
31
HIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomised phase 2 trial
... of CD4 + T-cell ...and CD4 counts between 200 and 500 cells/ ...level, CD4 count, CD4/CD8 ratio, in flammation and immune checkpoints from week 0 to week ...of CD4 count was ...
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Cytokine priming enables triggering of naive auto-reactive CD8[superscript +]T cells by weak agonist ligands of the TCR
... To determine whether cytokine stimulation enabled CDS+ T cells to respond to weak agonists, we pre-stimulated P14 cells with IL-21 in combination with IL-7 or IL-15 for 36[r] ...
96
Modulation of HIV-1 replication in primary dendritic cells in contact with autologous CD4 T-lymphocytes
... Results HIV-1 replication was enhanced in DCs cocultured with autologous CD4 T-lymphocytes compared to DCs alone. Slightly lower levels of SAMHD1 expression were detected in infected cocultured DCs by flow ...
2
Population dynamics of CD4+ T cells lacking Thy-1 in murine retrovirus-induced immunodeficiency syndrome (MAIDS).
... azide. Cells were washed twice and counterstained with streptavidin-PE or slreptavidin-Red 613 ...washes, cells were analysed on a FACStar Plus ® (Becton ...of CD4 + Thy-1 - and CD4 + Thy-1 + ...
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CD4+ T Helper Cells Play a Key Role in Maintaining Diabetogenic CD8+ T Cell Function in the Pancreas
... T cells–APCs contacts, four slices were randomly selected from at least three animals per group, and all cells present in a minimum of 10 different confocal images (700 μm × 700 μm × 20 μm) were ...
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