Muscle-invasive bladder cancer (MIBC)
Promoter hypermethylation of HS3ST2, SEPTIN9 and SLIT2 combined with FGFR3 mutations as a sensitive/specific urinary assay for diagnosis and surveillance in patients with low or high-risk non-muscle-invasive bladder cancer
... Background Bladder cancer (BCa) ranks among the five most common malignancies worldwide ...non-muscle-invasive bladder can- cer (NMIBC) with low-stage (CIS, pTa, pT1) and low or ...
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Inhibition of PI3K pathway increases immune infiltrate in muscle-invasive bladder cancer
... compared to MIBCs 34 . When we focused on MIBC tumor sub-type, we observed that MIBCs from patients bearing PIK3CA gene mutations but not BRAF, RAS or FGFR3 mutations were still significantly associated to ...
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Precision immunity: Immunoscore and neoadjuvant treatment in bladder cancer
... Integrative Cancer Immunology, INSERM, Paris, France; d Equipe Labellisée Ligue Contre le Cancer, Paris, France; e Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France ...
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APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer
... in bladder cancer (BLCA). Over 65% of non-muscle-invasive bladder cancer (NMIBC) and 15% of muscle-invasive bladder cancer (MIBC) carry an FGFR3 ...
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NOTCH pathway inactivation promotes bladder cancer progression
... the bladder carcinoma tumor set from TCGA (Supplemental Figure ...the muscle invasive bladder carcinomas (MIBC) compared with that in nonmuscle invasive tumors (Figure 6C and ...
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Safety and efficacy of temsirolimus as second line treatment for patients with recurrent bladder cancer
... Background Bladder cancer is the seventh most common cancer worldwide in men and occurs at a median age of 73 years old [ 1 ...as bladder cancer is associated with one of the highest ...
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Statistical methods for the integration analysis of -omics data (genomics, epigenomics and transcriptomics): An application to bladder cancer
... Limitations of this work are the small sample size of the discovery phase study, due to the lack of enough fresh tumor tissue from the same set of individuals, and the lack of a comparable and independent UBC patient ...
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Urinary levels of Hepatocarcinoma-intestine-pancreas/Pancreatitis-associated protein as a diagnostic biomarker in patients with bladder cancer.
... non-muscle invasive BCa Recurrence-risk and progression-risk scores are calculated for each patient according to the European Organisation for Research and Treatment of Cancer (EORTC) defin- ...
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Noninvasive detection of bladder cancer using mid-infrared spectra classification
... In an e↵ort to explore di↵erent pathways, optical-based methods have been described: In vivo optical imaging technologies as Photodynamic Diagnosis 35 (PDD), Narrow Band Imaging (NBI), Confocal Laser (CLE) and Optical ...
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Serum Matrix Metalloproteinase-7 is an independent prognostic biomarker in advanced bladder cancer
... MMP-7; Bladder cancer; Prognosis; Urothelial tumors; Serum; Biomarker; Tumor markers; Overall survival Background Bladder urothelial cell carcinoma (BUCC) is the fourth most common cancer in ...
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Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients.
... of Bladder Cancer: Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder ...cancer. Cancer Res 2009, ...
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Population model of bladder motion and deformation based on dominant eigenmodes and mixed-effects models in prostate cancer radiotherapy
... 2011). The SPHARM parameterization thus enabled us to reduce not only compu- tation time but also numerical errors, by affording finite arithmetic operations, and data storage while preserving shape information. However, ...
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Bladder Volume Decoding from Afferent Neural Activity
... urinary bladder due to spinal cord injury (SCI), neural diseases, health conditions, or aging, causes serious complications in a patient's ...restore bladder functions in drug-refractory patients using ...
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Pépite | Oesophagectomie mini-invasive selon Lewis-Santy pour cancer : impact de la thoracoscopie sur la morbidité opératoire
... Enfin, le taux de fistule anastomotique augmenté dans le groupe TMIE est dû à la courbe d’apprentissage de l’abord et de l’anastomose par thoracoscopie. L’évaluation de la courbe d’apprentissage et le nombre ...
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Atomic Force microscopy reveals a role for endothelial cell ICAM-1 expression in bladder cancer cell adherence
... ABSTRACT Cancer metastasis is a complex process involving cell-cell interactions mediated by cell adhesive ...most invasive cell lines (T24, J82) form the strongest bonds with endothelial ...most ...
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A detailed assessment of adverse perioperative outcomes of the elderly treated with radical cystectomy for bladder cancer
... disseminated state [100]. Clinical Implications Our results have the following clinical implications. First, we have reported greater POM rates for septuagenarian and octogenarian patients than were previously reported ...
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High-Grade Anal Intraepithelial Neoplasia: Progression to Invasive Cancer Is Not a Certainty
... 4. Edgren G, Sparén P. Risk of anogenital cancer after diagnosis of cervical intraepithelial neoplasia: a prospective population-based study. Lancet Oncol. 2007;8:311-6. 5. Darragh TM, Colgan TJ, Thomas Cox J, ...
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Survival of patients with invasive cervical cancer in French Guiana, 2003-2008.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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“Invasive” and “Non-invasive” Technologies in Neuroscience Communication
... In the clinical context, cost-benefit analyses appear totally different: a small dose of radiation is, of course, better than an erroneous diagnosis, and a surgical intervention is generally better than a tumor’s ...
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Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance
... A further layer of complexity is that the modulation of MT1-MMP surface levels, in relation with changes in NME1 expression such as the one we found in breast cancers, may affect other MMPs ’ function and membrane ...
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