MTOR pathway
Review: Mechanistic target of rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy
... complexes: mTOR complex 1 (mTORC1) when associated to the protein raptor or mTOR complex 2 (mTORC2) when bound to the protein ...of mTOR pathway activity is the phosphorylation by mTORC1 of ...
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28S rRNA is inducibly pseudouridylated by the mTOR pathway translational control in CHO cell cultures
... the mTOR pathway’s inhibition in CHO cells affected the expression of snoRNA U19 by measuring its level upon rapamycin ...to mTOR pathway (upon rapamycin treatment) was mediated in part through a ...
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mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD)
... the mTOR pathway and apoptosis was measured in a mouse model of PPNAD (AdKO mice), in human and mouse adrenocortical cell lines in response to pharmacological inhibitors and in PPNAD tissues by ...increased ...
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Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: Its potential use in the treatment of bladder cancers.
... signaling pathway that occupies a major place in the etiology of these ...PI3K/AKT/mTOR pathway and discuss the potential use of the different classes of PI3K/AKT/mTOR inhibitors in the ...
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Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway.
... with our “one-two punch” strategy, in which, after transcription initia- tion, RNA elongation and protein translation should follow. In this light it is not surprising that TCR stimulation, which can trig- ger ...
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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
... PI3K/mTOR pathway activation in ...PI3K/mTOR pathway members in a significant proportion of OS tumors ...PI3K/mTOR pathway members (PDPK1, AKT1, and EIF4B) containing somatic ...
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Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML
... and mTOR (MV4-11 sorafenib-resistant cells, Supplementary Table S4) genes in each set of cell ...activating mTOR mutations have been described, MV4-11 cells carry E2536A and this mutation has not been ...
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The LKB1 complex-AMPK pathway: the tree that hides the forest.: The LKB1 complex-AMPK pathway
... Conclusions Currently, there is no doubt that the LKB1 complex is at the centre of an important signalling node affecting numerous cellular processes whose deregulation contributes to pathologies such as Peutz-Jeghers ...
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Activation de la voie oncogénique mTOR par les formes mutées de l'isocitrate déshydrogénase 1/2 retrouvées chez les gliomes
... oncogenic mTOR signaling, thereby obviating the need for PTEN inactivation in ...the mTOR pathway by IDH1/2 ...Since mTOR controls cell size [9], we determined the physiological response to ...
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Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling.
... in mTOR (mammalian Target Of Rapamycin) signaling has attracted an increasing ...interest. mTOR senses and integrates a variety of environmental cues to regulate major cellular processes ...activate ...
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The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism
... hexosamine pathway, pentose phosphate pathway and amino acids contributing to increased cell ...the mTOR pathway, because rapamycin treatment reversed the glycolytic shift caused by p66Shc ...
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Etude comparative de nouvelles approches thérapeutiques dans le lymphome à cellules du Manteau : utilisation des inhibiteurs de mTOR kinase et BTK
... the mTOR pathway have an important clinical application in several human ...the mTOR pathway, highlights the need for ongoing ...competitive mTOR kinases inhibitors has a more ...
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JTC-801 Suppresses Melanoma Cells Growth through the PI3K‑Akt‑mTOR Signaling Pathways
... signaling pathway has been suggested to be a critical regulator mediating resistance to MAPK inhibitors [26, ...PI3K-Akt pathway as the putative target of JTC- 801-derived ...and mTOR [25]. The ...
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Is there a role for dual PI3K/mTOR inhibitors for patients affected with lymphoma?
... on mTOR, and a reduced activity on the off-target DNA-PK ...NFκB pathway, PI3K/AKT/mTOR pathway, mRNA processing, apoptosis, cell cycle, MAPK/RAS signaling, Myc pathway, and glycolysis ...
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Non-canonical mTOR-Independent Role of DEPDC5 in Regulating GABAergic Network Development
... of mTOR signaling was ...to mTOR-associated genes, many genes involved in synaptic function, neurogenesis, axonogenesis and GABA network activity were found to be dysregulated in larval ...
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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
... DISCUSSION The cell lines and conditions chosen for this study were designed to isolate mTORC1 signaling from mTORC2, upstream branching pathways, parallel pathways, and feedback mechanisms that all accompany mTORC1 ...
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Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
... Abstract mTOR is a highly conserved serine/threonine protein kinase that serves as a central regulator of cell growth, survival and ...signaling pathway occurs commonly in cancer and numerous inhibitors ...
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On the Diagnostic of Road Pathway Visibility
... francois.goulette@mines-paristech.fr Abstract Sight distance along the highway plays a significant role in road safety and in particular, has a clear impact on the choice of speed limits. Visibility distance is thus of ...
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La kinase FRAP/mTOR : une nouvelle cible dans le traitement des cancers dépendants de la voie PI3-kinase/PTEN
... 1. mTOR, une nouvelle cible dans le traitement des tumeurs présentant un dysfonctionne- ment de la voie PI ...de mTOR, une kinase impliquée dans la voie PI 3-kinase/Akt, conduit au blocage préférentiel des ...
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en fr Biochemical and cellular characterization of the interplay between glutamine metabolism, mTOR and Notch1 signaling in cancer therapy Caractérisation biochimique et cellulaire de l’interaction entre le métabolisme de la glutamine et la signalisation de mTOR et Notch1 comme thérapie contre le cancer
... 33 (folliculin-interacting proteins 1 and 2) have been described to operate as GAPs in mammals 108,109 , while no GEFs have been described so far. The question about how cells integrate the information about each amino ...
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