mitogen-activated protein
Rapid activation of phosphorylated mitogen-activated protein kinase after sexual stimulation in male mice.
... the protein products of IEG like c-fos or zif268 have become common tools for mapping functional activity in the brain, it is still difficult to link neuronal induction with precise behavioral parameters ...IEG ...
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Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes
... for mitogen-activated protein kinase studies Nonadherent chondrocytes were treated with various pharmacological inhibitors for 60 min then stimulated with OCP crystals or ...the protein ...
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Regulation of ES Cell Lineage Commitment by Mitogen Activated Protein Kinases
... of mitogen-activated protein kinases (MAPKs) and their downstream effects on gene regulation represent a paradigm in cellular signalling (see reviews [12, ...These protein serine/threonine ...
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Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes.
... pharmacological and cytokine inhibitors, we observed that OCP crystals induced NO production and inducible NOS mRNA activation were regulated at both the transcriptional and the translational levels; were independent ...
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The FRK1 mitogen-activated protein kinase kinase kinase (MAPKKK) from Solanum chacoense is involved in embryo sac and pollen development
... nuclear-localized mitogen-activated protein kinase kinase kinase (MAPKKK) from the wild potato species Solanum chacoense, belongs to a small group of pMEKKs that do not pos- sess an extended N- or ...
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Knock-down of filaggrin influences the mitogen-activated protein kinases signaling pathway in normal human epidermal keratinocytes
... The mitogen-activated protein kinases (MAPK) signaling pathway has been revealed to play critical roles in epidermal differentiation and skin barrier ...
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Quantitative Phosphoproteomic Analysis Reveals Shared and Specific Targets of Arabidopsis Mitogen-Activated Protein Kinases (MAPKs) MPK3, MPK4, and MPK6
... Arabidopsis, mitogen-activated protein kinases MPK3, MPK4, and MPK6 constitute essential relays for a variety of functions including cell division, development and in- nate ...
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The release of pro-inflammatory cytokines is mediated via mitogen-activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes
... 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 ...
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In vitro glycoxidized low-density lipoproteins and low-density lipoproteins isolated from type 2 diabetic patients activate platelets via p38 mitogen-activated protein kinase.: glycoxidized LDL activates platelets
... Introduction Oxidative stress has been identified as one of the factors closely associated with platelet hyperactivation in type 2 diabetic patients (1) even in the absence of any vascular complications (2). It remains ...
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p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells.: P38 CONTROLS THE MESODERMAL COMMITMENT OF ES CELLS
... p38 protein levels, between 23% and 46% of levels present in wt cells, at day 4 of differentiation ...MAPK activated protein kinase-2 (MAPKAP-K2) ...MAPKAP-K2 protein is a good indication of ...
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Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.: Crosstalks between the MAP kinase and Smad pathways
... be activated by various MAPKKKs in response to many ...be activated by TGF- family members is TGF- -activated kinase 1 (TAK1), originally identified as a MAPKKK activated by TAB1 (for TGF- ...
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The estrogen effects on endothelial repair and mitogen-activated protein kinase activation are abolished in endothelial nitric-oxide (NO) synthase knockout mice, but not by NO synthase inhibition by N-nitro-L-arginine methyl ester.
... eNOS protein, but not eNOS activity, in the endothelial cells of carotid ...between protein expression and enzymatic activity was nicely demonstrated for PI3Kγ 39 which participates in two distinct ...
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Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to Hydrogen peroxide-induced oxidative stress in Human hepatobiliary Cancer cells
... MAPK-activated protein kinase 2 (MK2)/Heat shock protein 27 (Hsp27) signaling pathway mediating defenses against oxidative ...is activated by hydrogen peroxide-induced oxidative stress in ...
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Rôle du couple Flt3-ligand/Flt3 et de l'activation des "Mitogen-activated protein kinases" p38 dans la dysmégacaryopoïèse des patients atteints de myélofibrose primitive
... 12.4.2.3/Ostéomyélosclérose et Néoangiogenèse Les mécanismes à l’origine de l’ostéosclérose et de la néoangiogenèse, qui font partie intégrante de la réaction stromale, sont actuellement moins bien connus que ceux de la ...
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Mitogen-activated protein kinases play an essential role in oxidative burst-independent expression of pathogenesis-related genes in parsley
... be activated in this system, confirming this tyrosine phos- phorylation reaction as essential for kinase activation during the elicitor response that likely results from activation of an upstream MAPKK ...be ...
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Adenosine A2A receptor blockade prevents synaptotoxicity and memory disfunction caused by beta-amyloid via p38 mitogen-activated protein kinase pathway
... Finally, this study demonstrates that neuroprotection result- ing from A 2A R blockade does not involve the cAMP/protein ki- nase A transducing system but instead depends on control of p38 MAPK. In fact, the ...
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Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling
... of protein/lane), as measured using bisbenzimide (30). Protein concentration was determined by the Bradford method (Bio-Rad protein assay kit, Hercules, CA) using bovine serum albumin as the ...
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Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process
... AMP-activated protein kinase (AMPK), the main intracellular energy sensor, is hyper-activated in degenerating neurons in several neurodegenerative diseases, including ...
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Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
... INTRODUCTION PPAR, and (NR1C1, NR1C2, NR1C3)(1), which are encoded by separate genes and exhibit distinct tissue-distribution, belong to the nuclear receptor superfamily (2). This family includes receptors for ...
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Distinct Protein Expression Networks are Activated in Microglia Cells after Stimulation with IFN-γ and IL-4
... of protein modulation related to RNA and cellular metabolic ...the protein changes specific to M1 and M2 activation states, and potentially link the polarization of microglia cells to the acquisition of a ...
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