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Metabolic stress

Metabolic stress-induced joint inflammation and osteoarthritis

Metabolic stress-induced joint inflammation and osteoarthritis

... Major metabolic stress inducing inflammation in ...the metabolic OA phenotype, several pathways and metabolic stress factors are involved: i) obesity activates chondrocytes through ...

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Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress

Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress

... exclude that free ThDP might have other physiological roles. Conclusion In E. coli, AThTP can be synthesized from free cellular ThDP and ADP or ATP. It accumulates (up to 15% of total thiamine) in response to different ...

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Regulation of lipogenesis in human adipose tissue: effect of metabolic stress, dietary intervention and aging

Regulation of lipogenesis in human adipose tissue: effect of metabolic stress, dietary intervention and aging

... other metabolic capacities of ER are overwhelmed is referred to as endoplasmic reticulum stress ...for metabolic health was con firmed by experiments on rodents corroborating ERS as a trigger of ...

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Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells

Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells

... conditions. Metabolic stress induced by the pyruvate dehydrogenase kinase-1 (PDK1) inhibitor dichloroacetate (DCA) inhibits the macroautophagy ...of metabolic stress, 17- AAG induces the ...

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Women have greater (Metabolic) Stress Response than Men

Women have greater (Metabolic) Stress Response than Men

... What if women and men had different metabolic response to treatment? W OMEN ARE MORE INSULIN RESISTANT THAN MEN , PROBABLY REFLECTING HIGHER STRESS RESPONSE Fig. 1. Schematic representation of the ...

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Metabolic Regulation of Inflammation in Osteoarthritis

Metabolic Regulation of Inflammation in Osteoarthritis

... biogenesis, cellular metabolism, autophagy, and DNA repair (59). Increasing evidence indicates that aging, joint injury, low-grade inflammation, and possibly nutritional overload, obesity and MetS impair normal function ...

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On the identifiability of metabolic network models.

On the identifiability of metabolic network models.

... The rank analysis carried out to determine the identifiability of a reaction also shows how the model can be reduced if the data does not allow the parameters of the model to be unambiguously determined. This reduction ...

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Autophagy-mediated metabolic effects of aspirin

Autophagy-mediated metabolic effects of aspirin

... Abstract Salicylate, the active derivative of aspirin (acetylsalicylate), recapitulates the mode of action of caloric restriction inasmuch as it stimulates autophagy through the inhibition of the acetyltransferase ...

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Global Gene Regulation in Metabolic Networks

Global Gene Regulation in Metabolic Networks

... that metabolic reactions happen in a much faster time scale when compared to gene transcription or translation ...the metabolic dynamics by a system of algebraic ...regulated metabolic chain (Section ...

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Recreating ancient metabolic pathways before enzymes

Recreating ancient metabolic pathways before enzymes

... existing metabolic networks, rather than re-written them completely? We felt that the absence of evidence for a non- enzymatic proto-metabolism resembling biochemistry was simply due to the lack of sustained ...

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Les représentations du stress des dirigeants : quelles implications pour la gestion du stress au travail ?

Les représentations du stress des dirigeants : quelles implications pour la gestion du stress au travail ?

... Pour répondre à cette question, nous pouvons nous appuyer sur les travaux de recherche s’intéressant aux interventions organisationnelles ayant pour objet la gestion du stress des employés. Ces travaux, ...

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Exercise efficiency impairment in metabolic myopathies

Exercise efficiency impairment in metabolic myopathies

... unknown 4 , 6 . Due to these factors, reduction in peak exercise oxygen consumption (V’O 2 max , mLO 2 .min −1 .kg −1 ) is commonly observed in patients with metabolic myopathies 1 – 6 , 13 – 16 . During ...

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Nonenzymatic Metabolic Reactions and Life’s Origins

Nonenzymatic Metabolic Reactions and Life’s Origins

... discusses metabolic pathways of relevance to the origin of life in a manner accessible to chemists, and summarizes experiments suggesting several pathways might have their roots in prebiotic ...

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Metabolic syndrome and disability: findings from the prospective three-city study.: Metabolic Syndrome and disability

Metabolic syndrome and disability: findings from the prospective three-city study.: Metabolic Syndrome and disability

... MetS: metabolic syndrome; TG: triglycerides; BP: blood pressure; FBG: fasting blood glucose; IADL: instrumental activities of daily living β : logistic regression coefficient; SE: Standard Error ...

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Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer

... ments because they can dramatically in fluence p53 activities. More suprisingly, con flicting results have also been reported when the metabolic functions of p53 were assessed in vivo, even sometime using the same ...

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13C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes

13C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes

... of metabolic activation in response to insulin can be ex- plained by the slight decrease observed in glucose up- take and the increase of lactate dehydrogenase flux directed to lactate production, which impaired ...

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Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

... Glucose is the most highly consumed fuel of proliferating cells, including cancer cells and proliferating lymphocytes. Glucose is needed to produce ribose used in nucleotide biosynthesis, glycolytic intermediates that ...

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RetroPath2.0: A retrosynthesis workflow for metabolic engineers

RetroPath2.0: A retrosynthesis workflow for metabolic engineers

... can be processed by the work flow including problems where com- pounds are not metabolites and reactions are not metabolic reactions. The most critical feature of a reaction network prediction system is certainly ...

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Automated reasoning in metabolic networks with inhibition

Automated reasoning in metabolic networks with inhibition

... Future works can focus on extending the language used to define domain formulas, introducing for example the notion of time as in [2]. Trying to get as precise as possible in describing such pathways can help biologists ...

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Stress, stress, stress...La municipalité de Toulouse face à la crise financière, à la crise urbaine et à la crise économique entre 1910 et 1940

Stress, stress, stress...La municipalité de Toulouse face à la crise financière, à la crise urbaine et à la crise économique entre 1910 et 1940

... En dépit de la politique du pouvoir central dénoncée comme "malthusienne" et vivement contestée par les élus locaux qui lui opposent les solutions keynésiennes du New-Deal, l'équipe municipale va déployer des ...

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