Lymphocytic Leukemia
Clinical Implications of Novel Genomic Discoveries in Chronic Lymphocytic Leukemia
... J Clin Oncol 35:984-993. © 2017 by American Society of Clinical Oncology Chronic lymphocytic leukemia (CLL) is char- acterized by the accumulation and proliferation of clonal B cells in the blood, marrow, ...
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State-of-the-art for CAR T-cell therapy for chronic lymphocytic leukemia in 2019
... Keywords: CLL, CAR T cells, Ibrutinib Introduction Chronic lymphocytic leukemia (CLL) is the most common lymphoid hemopathy (estimated incidence of 2 to 4 cases per 100,000 inhabitants/year). It is ...
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Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males.
... Background: The sensitivity of chronic lymphocytic leukemia (CLL) cells to current treatments, both in vitro and in vivo, relies on their ability to activate apoptotic death. CLL cells resistant to DNA ...
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CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans
... Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia (cancer of the white blood ...infections. Leukemia begins when a bone mar- row cell acquires genetic changes ...
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Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway
... Chronic lymphocytic leukemia (CLL) is a very heterogeneous disease characterized by a peripheral accumulation of abnormal CD5 + B lymphocytes in the blood, bone marrow and lymphoid tissues [ 15 ...
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“Double-hit” chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain
... Chronic lymphocytic leukemia with isochromosome 17q: An aggressive subgroup associated with TP53 mutations and complex ...chronic lymphocytic leukemia: acquisition of high-risk genomic ...
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Study of chronic lymphocytic leukemia cells by FT-IR spectroscopy and cluster analysis
... Abstract-The peripheral mononuclear cells from 23 normal individuals and the purified B cells from 38 patients with chronic lymphocytic leukemia (CLL) were examined[r] ...
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CD49d promotes disease progression in chronic lymphocytic leukemia : new insights from CD49d bimodal expression
... CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups ...
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Activated Allogeneic NK Cells Preferentially Kill Poor Prognosis B-Cell Chronic Lymphocytic Leukemia Cells
... Mutational status of TP53 together with expression of wild-type (wt) IGHV represents the most widely accepted biomarkers, establishing a very poor prognosis in B-cell chronic lymphocytic leukemia (B-CLL) ...
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Ibrutinib in very elderly patients with relapsed/refractory chronic lymphocytic leukemia: A real-world experience of 71 patients treated in France: A study from the French Innovative Leukemia Organization (FILO) group
... Innovative Leukemia Organization (FILO) group To the Editor: In first-line therapy, 20% of patient with chronic lymphocytic leukemia (CLL) are even 80 years old or over, rendering therapeutic ...
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Identification of a 20-gene expression-based risk score as a predictor of clinical outcome in chronic lymphocytic leukemia patients.
... Copyright © 2014 Elias Bou Samra et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
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Obinutuzumab plus fludarabine and cyclophosphamide in previously untreated, fit patients with chronic lymphocytic leukemia: a subgroup analysis of the GREEN study
... Received: 28 March 2019 / Revised: 21 June 2019 / Accepted: 4 July 2019 / Published online: 27 August 2019 © The Author(s) 2019. This article is published with open access Abstract GREEN (NCT01905943) is a nonrandomized, ...
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Evaluation of Caspase-9b and PP2Acα2 as potential biomarkers for chronic lymphocytic leukemia
... Chronic lymphocytic leukemia, Alternative splicing, Biomarker Introduction Chronic lymphocytic leukemia (CLL) is the most common B-cell malignancy in Caucasian aging adults, rarely younger ...
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en fr Analysis of immunoregulatory CD5⁺CD19⁺ subpopulations in chronic lymphocytic leukemia and of the impact of ibrutinib therapy on these subpopulations Analyse des sous-populations lymphocytaires B dans la leucémie lymphoïde chronique et de l'Impact de l'ibrutinib sur ces sous-populations
... Chronic Lymphocytic Leukemia (CLL) is a mature CD5 + B cells neoplasm that accumulates in the peripheral blood and other tissues, including bone marrow, spleen and lymph nodes ...
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Prognosis of chronic lymphocytic leukemia from infrared spectra of lymphocytes
... Peripheral mononuclear cells obtained from blood of normal individuals and from patients with chronic lymphocytic leukemia (CLL) were investigated by infrared spectr[r] ...
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International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia
... We consecutively performed both uni- and multivariable anal- yses using the full data set of the training cohort (UEP). Sub- sequently, we analyzed the external validation data sets to confirm the findings from the ...
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Nurse-like cells impact on disease progression in chronic lymphocytic leukemia
... Chronic lymphocytic leukemia (CLL) is one of the most common B-cell malignancies in adults, characterized by an accumulation of monoclonal CD5 + mature B cells in lymphoid tissues and peripheral ...a ...
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Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia
... Abstract RIP140 is a transcriptional coregulator, (also known as NRIP1), which finely tunes the activity of various transcription factors and plays very important physiological roles. Noticeably, the RIP140 gene has been ...
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Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance
... myeloid leukemia (AML), including pediatric patients 15 – 18 ...chronic lymphocytic leukemia (B-CLL) is the most common leukemia in adults in the Western world and is characterized by the ...
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Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia
... Introduction Nuclear factor- κB (NF-κB) signaling is a key component of the development and evolution of chronic lymphocytic leukemia (CLL). 1 Two NF- κB pathways exist, namely the canonical and ...
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