lung adenocarcinoma
Comprehensive molecular profiling of lung adenocarcinoma
... of lung adenocarcinoma The Cancer Genome Atlas Research Network Abstract Adenocarcinoma of the lung is the leading cause of cancer death ...resected lung adenocarcinomas using messenger ...
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BMI1 is a context-dependent tumor suppressor that is a barrier to dedifferentiation in non-small cell lung adenocarcinoma
... autochthonous lung adenocarcinoma, driven by oncogenic Kras and Tp53 loss (KP LUAD), and subsequent deletion of Bmi1 specifically within the tumor cells once more than half the tumors progress to grade 3 or ...
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Role of microRNAs in progression and recurrence of early-stage lung adenocarcinoma
... MicroRNA assay of tissue and plasma The miRNA PCR Array for Cancer (MAH-102F; SA Biosciences, Burlington, ON, Canada) containing 88 cancer- relevant microRNA-probes and 8 controls in a 96-well plate was employed to ...
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Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma
... Introduction Lung cancer is the leading cause of cancer mortality worldwide ...of lung adenocarcinoma (LUAD), the major subtype of non–small cell lung cancers (NSCLCs) ...
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International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
... predominantly lung adenocarcinoma histology, one which selected patients clinically, and three which selected patients by EGFR mutations have demonstrated that patients with EGFR mutation lung cancer ...
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The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism
... Figure 5. HDACs inhibited gefitinib-induced apoptosis in NSCLC cells via activation of AKT. H358 cells were treated as described in Figure 4. Representative immunoblots of cleaved caspase-3, AKT and ERK1/2 and of their ...
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Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu.
... Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu 夽,夽夽 J. De Grève a , ∗ , E. Teugels a , C. Geers a , L. Decoster a , D. ...
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Microarray analysis identifies pathways in progression of early stage lung adenocarcinoma: the importance of focal adhesion and ECM-receptor interactions
... invasive adenocarcinoma samples also identiied CRABP2 as up-regulated in adenocarcinoma in situ compared to normal lung, 41 strongly implicating it in NSCLC ...
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Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press
... in lung cancer and have concluded that loss of MUC4 results in epithelial mesenchymal transition via beta catenin nuclear translocation and that MUC4 expression is correlated with a risk of lymph node metastasis ...
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Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor performance status
... in lung adenocarcinoma, SRSF1 overexpression is associated with a more aggressive phenotype, the presence of metastases, and chemotherapy resistance [ 43 ...
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en fr Control of EGFR-L858R oncogenic signaling pathway by the p14ARF tumor suppressor in lung adenocarcinoma. Contrôle de la signalisation oncogénique du mutant L858R de l'EGFR par la protéine suppresseur de tumeur p14ARF dans les adénocarcinomes pulmonaires
... against lung cancer development (Eymin et ...human lung cancer, especially in small cell lung cancer and lung adenocarcinoma (Gazzeri et ...all lung adenocarcinoma with ...
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Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells.
... We examined herein the effects of tumor necrosis factor (TNF)-α and regulators of protein kinases C (PKC)α/β on the expression of RANTES and IL-8 in A549 lung adenocarcinoma cells. TNF-α is a major mediator ...
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NRG1 fusion in a French cohort of invasive mucinous lung adenocarcinoma
... 6 © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. M. Duruisseaux et al. NRG1 Fusion in Mucinous Lung Adenocarcinoma in our study could be due to the lesser sensitivity of FISH ...
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P2RX7B is a new theranostic marker for lung adenocarcinoma patients
... INTRODUCTION Lung cancer is the leading cause of cancer-related death in the ...of lung cancers are diagnosed at an advanced stage [1] and need medical treatment including chemotherapy, targeted therapies ...
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Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma
... 13. Baumgart A, Mazur PK, Anton M, Rudelius M, Schwamborn K, Feuchtinger A, et al. Opposing role of Notch1 and Notch2 in a Kras-driven murine non-small cell lung cancer model. Oncogene. 2014. 14. Maraver A, ...
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Lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma of the lung exhibit specific mucin expression in relation with oncogenic drivers
... alterations, Lung Cancer 81 (2013) ...of Lung Cancer/American Thoracic Society/European Respiratory Society classification system of lung adenocarcinoma is a stage-independent predictor of ...
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Circadian Rhythm Disruption Promotes Lung Tumorigenesis
... components leads to increased proliferation, c-Myc levels/activation and metabolic activity. Our results highlight the importance of cell-autonomous circadian control of fundamental cellular processes that are known ...
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Interstitial lung diseases in children.
... regulation of cell proliferation and migration and tissue remodeling, predominantly by polypeptide growth fac- tors [54]. The slowing of wound healing that occurs in the aged may be related to changes in the activity of ...
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Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required
... Figure 1: Atg5 level and pancreatic carcinogenesis (A) Schematic summary of Görgülü manuscript about homozygous and monoallelic loss of Atg5 in Ptf1- Cre;LstopL-KrasG12D mice (B) Overall survival values of Atg5 high/low ...
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XPO1 Expression Is a Poor-Prognosis Marker in Pancreatic Adenocarcinoma
... Abstract: Pancreatic adenocarcinoma (PAC) is one of the most aggressive human cancers and new systemic therapies are urgently needed. Exportin-1 (XPO1), which is a member of the importin-β superfamily of ...
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