Liver X Receptor (LXR)
Liver X Receptor: an oxysterol sensor and a major playerin the control of lipogenesis
... farnesoid X receptor; GK, gluco kinase; GPAT, glycerol-3-phosphate acyltransferase; GSM, glucose sensing domain; GTF, general transcription factor; HAT, histone acetyltransferase; HDAC, histone deacetylase; ...
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Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve
... Mehdi Hichor 1 , Venkat Krishnan Sundaram 1 , Stéphanie A. Eid 1 , Ronza Abdel-Rassoul 1 , Patrice X. Petit 1 , Didier Borderie 1 , Jean Bastin 1 , Assaad A. Eid 2 , Marin Manuel 3 , Julien Grenier 1 & Charbel ...
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Regulation of the Aldo-Keto Reductase Gene akr1b7 by the Nuclear Oxysterol Receptor LXRα (Liver X Receptor-α) in the Mouse Intestine: Putative Role of LXRs in Lipid Detoxification Processes
... The intriguing finding that malondialdehyde levels in duodenum of mice fed T1317 (Fig. 5A) or 2% choles- terol (data not shown) provided in vivo evidence sug- gesting that LXRs are involved in protection against lipid ...
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Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α
... HepaRG cells have been used in a variety of studies, including those involving liver toxicity [49,50] , hepatitis viruses infection [51] , human hepatic diseases and differentiation. The currently used ...
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Rôle du Liver X Receptor dans la régulation transcriptionnelle de la lipogenèse
... By measuring the expression of 142 genes involved either in lipid metabolism or in nuclear receptor signalling, we were able to further evaluate the role of LXRs. First, we identified that LXRs are central for FA ...
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Identification of the Functions of Liver X Receptor-β in Sertoli Cells Using a Targeted Expression-Rescue Model
... Given that germ cells are known to express both LXR isoforms in the wild-type mice, we took advantage of the Sertoli cell-specific LXR  expression in the Lxr␣ ⫺/⫺ ; Lxr  ⫺/⫺ :AMH-Lxr [r] ...
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Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling
... not change in wild-type mice but increases in LXR knockout mice fed the oleic acid-rich diet ( Fig 4A ). This cluster contains genes encoding for TNF-α and IL-1β whose expression is asso- ciated with the one of CXCL10, ...
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Liver X Receptors: A Possible Link between Lipid Disorders and Female Infertility
... Nutrient and hormone exchanges between maternal and fetal circulation take place through the placenta, which also constitutes a barrier against toxins, in order to protect the fetus. Cholesterol is supplied by maternal ...
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Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases?
... Figure 2. Involvement of LXRs in neurodegenerative diseases. LXRs are central regulators of both cholesterol and oxysterol metabolisms. They have multiple roles in brain functions. Dysregulations of LXR-controlled ...
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Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases?
... Figure 2. Involvement of LXRs in neurodegenerative diseases. LXRs are central regulators of both cholesterol and oxysterol metabolisms. They have multiple roles in brain functions. Dysregulations of LXR-controlled ...
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Liver X receptors, lipids and their reproductive secrets in the male
... ACCEPTED MANUSCRIPT Abstract Liver X receptor (LXR) α and LXR β belong to the nuclear receptor superfamily. For many years they have been called orphan receptors, as no natural ligand was ...
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Liver X receptors, lipids and their reproductive secrets in the male
... Studies on mice pointed out that LXR-deficiency could be associated with several phenotypes resembling putative diseases found in human such as metabolic disorders, reproductive failures, central nervous system ...
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Perturbations métaboliques hépatiques : implication des xénosenseurs CAR (Constitutive Androstane Receptor) et PXR (Pregnane X Receptor) et d'un perturbateur endocrinien, le Bisphénol A
... fatty liver disease (NAFLD) is an emerging epidemic ...the liver X receptor (LXR) and the carbohydrate response element binding protein (ChREBP), known to be key mediators of lipid and glucose ...
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Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.
... Figure legends Figure 1. Selective depletion of hepatic stellate cells or antagonism of 5-HT 2B stimulates liver growth. Mice underwent bile duct ligation (BDL) or sham operation. Fourteen days later BDL mice were ...
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The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.: PPARalpha controls the expression of the sIL-1ra in liver
... 3.4. sIL-1ra is a true target gene of PPARα in mouse liver To determine whether the sIL-1ra promoter is directly regulated by PPAR , 1.9 kb of promoter region of the soluble isoform was cloned into a luciferase ...
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Farnesoid x receptor deficiency improves glucose homeostasis in mouse models of obesity.
... and liver steatosis aggravated due to the repression of β-oxidation ...agreement, liver- specific FXR-deficiency did not protect from diet-induced obesity and insulin resistance indicating a role for ...
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Glucocorticoid receptor-PPAR alpha axis in fetal mouse liver prepares neonates for milk lipid catabolism
... (Rakhshandehroo et al., 2010). This implicates that the reduced oxidative capacity observed in Ppara -/- mice was due to the lack of direct PPARa-mediated stimulatory effects rather than a cellu- lar-autonomous ...
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Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB
... pathogen liver cell ...human liver cells through analysis of 120 different CD81 co-immunoprecipitations (co-IP) and high-resolution quantita- tive mass ...
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Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA.
... LIF receptor expression The expression of the gp190 subunit by liver cells was then examined by ...normal liver tissue, LIF receptor (LIF-R) expression was detected as a continuous sinusoidal ...
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Alcoholic liver disease: when to consider liver transplantation?
... offer liver transplantation to the patients with ALD who are most capable of maintaining sobriety, alcohol relapse after transplantation is not ...after liver transplantation are highly vari- able and range ...
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