Liver X Receptor
Liver X Receptor: an oxysterol sensor and a major playerin the control of lipogenesis
... farnesoid X receptor; GK, gluco kinase; GPAT, glycerol-3-phosphate acyltransferase; GSM, glucose sensing domain; GTF, general transcription factor; HAT, histone acetyltransferase; HDAC, histone deacetylase; ...
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Rôle du Liver X Receptor dans la régulation transcriptionnelle de la lipogenèse
... glucocorticoid receptor » (GR) (Weitzel, Stark et ...activated receptor α » (PPARα) inhibent la synthèse des acides biliaires et facilitent la sécrétion de phospholipides dans la bile, limitant ainsi la ...
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Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve
... Mehdi Hichor 1 , Venkat Krishnan Sundaram 1 , Stéphanie A. Eid 1 , Ronza Abdel-Rassoul 1 , Patrice X. Petit 1 , Didier Borderie 1 , Jean Bastin 1 , Assaad A. Eid 2 , Marin Manuel 3 , Julien Grenier 1 & Charbel ...
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Regulation of the Aldo-Keto Reductase Gene akr1b7 by the Nuclear Oxysterol Receptor LXRα (Liver X Receptor-α) in the Mouse Intestine: Putative Role of LXRs in Lipid Detoxification Processes
... complex, suggesting that this band contains RXR/ LXR ␣ heterodimer. The ability of the LXRE1 and LXRE2 oligos to bind the RXR/LXR heterodimer was demonstrated by using unlabeled probes to com- pete for binding to the ...
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Identification of the Functions of Liver X Receptor-β in Sertoli Cells Using a Targeted Expression-Rescue Model
... Given that germ cells are known to express both LXR isoforms in the wild-type mice, we took advantage of the Sertoli cell-specific LXR  expression in the Lxr␣ ⫺/⫺ ; Lxr  ⫺/⫺ :AMH-Lxr [r] ...
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Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α
... end-stage liver disease. Finally, it is also possible to accelerate liver regeneration in vivo by liver-specific target delivery of NR1H3 agonists, such as to package agonists into ...
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Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling
... the liver [ 9 ], we focused on hepatic lipid metabolism and in particular on ...nuclear receptor signaling and inflammation, we identified a cluster of genes following the same modulation pattern as hepatic ...
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Liver X Receptors: A Possible Link between Lipid Disorders and Female Infertility
... Nutrient and hormone exchanges between maternal and fetal circulation take place through the placenta, which also constitutes a barrier against toxins, in order to protect the fetus. Cholesterol is supplied by maternal ...
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Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases?
... Conflicts of Interest: The authors declare no conflict of interest. Figure 2. Involvement of LXRs in neurodegenerative diseases. LXRs are central regulators of both cholesterol and oxysterol metabolisms. They have ...
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Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases?
... Conflicts of Interest: The authors declare no conflict of interest. Figure 2. Involvement of LXRs in neurodegenerative diseases. LXRs are central regulators of both cholesterol and oxysterol metabolisms. They have ...
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Liver X receptors, lipids and their reproductive secrets in the male
... ACCEPTED MANUSCRIPT Abstract Liver X receptor (LXR) α and LXR β belong to the nuclear receptor superfamily. For many years they have been called orphan receptors, as no natural ligand was ...
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Liver X receptors, lipids and their reproductive secrets in the male
... Studies on mice pointed out that LXR-deficiency could be associated with several phenotypes resembling putative diseases found in human such as metabolic disorders, reproductive failures, central nervous system ...
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Perturbations métaboliques hépatiques : implication des xénosenseurs CAR (Constitutive Androstane Receptor) et PXR (Pregnane X Receptor) et d'un perturbateur endocrinien, le Bisphénol A
... fatty liver disease ...as liver X Receptor, the sterol regulatory element binding pro- tein-1c, and the carbohydrate responsive element binding protein that govern the expres- sion of ...
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Glucocorticoid receptor-PPAR alpha axis in fetal mouse liver prepares neonates for milk lipid catabolism
... neonatal liver, however, we show that mitochondrial b-oxidation prevails as the major contributor to the neonatal oxidative capacity and protects against hepatic steatosis when faced with a sudden surge in dietary ...
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The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.: PPARalpha controls the expression of the sIL-1ra in liver
... 3.4. sIL-1ra is a true target gene of PPARα in mouse liver To determine whether the sIL-1ra promoter is directly regulated by PPAR , 1.9 kb of promoter region of the soluble isoform was cloned into a luciferase ...
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Farnesoid x receptor deficiency improves glucose homeostasis in mouse models of obesity.
... BA receptor (TGR5), the pregnane X receptor (PXR), the vitamin D receptor (VDR) or the formyl peptide receptor (FPR) ...LDL receptor activity ...
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Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.
... whole liver up to 4 hrs post PHX in WT and KO mice (d,e). Liver TGFβ1 mRNA levels were quantified in KO and WT mice up to 72 hrs post PHX ...(f). Liver/body weight ratio was calculated in mice ...
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Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB
... pathogen liver cell ...human liver cells through analysis of 120 different CD81 co-immunoprecipitations (co-IP) and high-resolution quantita- tive mass ...
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Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA.
... LIF receptor expression The expression of the gp190 subunit by liver cells was then examined by ...normal liver tissue, LIF receptor (LIF-R) expression was detected as a continuous sinusoidal ...
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Alcoholic liver disease: when to consider liver transplantation?
... offer liver transplantation to the patients with ALD who are most capable of maintaining sobriety, alcohol relapse after transplantation is not ...after liver transplantation are highly vari- able and range ...
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