Leishmania donovani
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Leishmania donovani induit un défaut d’acidification du phagosome
... protozoaire Leishmania donovani, un parasite qui infecte les macrophages du foie, de la rate et de la moelle ...traitée. Leishmania est transmis à l’humain par voie sanguine sous sa forme ...
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In vitro effects of purine and pyrimidine analogues on Leishmania donovani and Leishmania infantum promastigotes and intracellular amastigotes
... 1 Université de Lyon, Université Claude-Bernard Lyon I, ISPB-Faculté de Pharmacie, Lyon, France; 2 Institut de recherche pour le développement (IRD), UMR InterTryp IRD/CIRAD, campus international de Baillarguet, ...
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Multifaceted population structure and reproductive strategy in Leishmania donovani complex in one Sudanese village.
... genus Leishmania totals approximately 20 described species causing human infections (reviewed in [2]) with a wide variety of clinical symptoms: cutaneous, visceral, mucocutaneous, mucosal and post-kala-azar dermal ...
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Synthesis and biological evaluation against Leishmania donovani of novel hybrid molecules containing indazole-based 2-pyrone scaffolds
... 2-Pyrone is an important class heterocyclic scaffold. Due to its pharmacophore properties, synthesis of hybrid derivatives bearing 2-pyrone moiety has attracted much attention; most of the compounds display strong ...
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Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia
... reported to generate decreased antibody responses ( Pasare and Medzhitov, 2005; Kasturi et al., 2011 ). The role of B cell TLR signaling in antibody production has mainly been studied in models of autoimmune diseases. ...
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Immunostimulatory properties of dendritic cells after Leishmania donovani infection using an in vitro model of liver microenvironment.
... of Leishmania donovani, a protozoan parasite that grows in liver and spleen tissues after infection (called visceral leishmaniasis in South America and Mediterranean basin, and Kala Azar in South East ...
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Changes in Lipid and Fatty Acid Composition During Intramacrophagic Transformation of Leishmania donovani Complex Promastigotes into Amastigotes
... Introduction Leishmania donovani and ...dogs. Leishmania is an intracellu- lar pathogen, whose establishment depends on its success- ful internalization and multiplication inside macrophages, its ...
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Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani
... pathogen Leishmania donovani Pablo Prieto Barja, Pascale Pescher, Giovanni Bussotti, Franck Dumetz, Hideo Imamura, Darek Kedra, Malgorzata Domagalska, Victor ...
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Analysis of genetic polymorphisms and tropism in East African Leishmania donovani by Amplified Fragment Length Polymorphism and kDNA minicircle sequencing
... L. donovani strains from VL, PKDL and HIV/VL patients was examined using Ampli fied Fragment Length Polymorphism (AFLP), kDNA minicircle sequencing and Southern ...L. donovani 28S rRNA gene only minor ...
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Activité des MAPKs et de NF-KB chez le macrophage infecté par Leishmania donovani
... Nous avons ensuite choisi des macrophages dérivés de la moelle osseuse (BMM) de souris BALB/c comme modèle d'infection. Les macrophages, traités ou non à l'IFN-y, ont ét[r] ...
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Modulation des radeaux lipidiques et des propriétés de fusion des phagosomes par le lipophosphoglycane du parasite intracellulaire Leishmania donovani
... Finalement, nous avons aussi identifié sur le phagosome plusieurs protéines reconnues comme étant présentes dans les radeaux lipidiques de la membrane plasmique, telles que la flotiÏline[r] ...
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Study of Leishmania pathogenesis in mice : experimental considerations
... investigate the pathogenic diversity, the impact of the host genetic background and of the Leishmania genotypes, animal models are widely used. Classically, in infected animals, parasite-activated CD4 + T cells ...
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Case Report: Leishmania and HIV Co-Diagnosis: How to Understand Medical History?
... of Leishmania donovani or infantum infection with potential severe complications (cachexia, hepatic dysfunction, hemorrhages and - almost always without proper treatment - ...
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Antimony resistance and environment: Elusive links to explore during Leishmania life cycle
... like Leishmania donovani and most foci of Leishmania tropica, parasites are trans- mitted from patients to patients by the bite of a ...that Leishmania will encouter will be during the ...
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Multilocus microsatellite typing of Leishmania and clinical applications: a review
... and Leishmania (Leishmania) donovani belong to the species complex Leishmania donovani, while Leishmania (Leishmania) tropica and Leishmania (Leish- mania) major ...
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Les facteurs solubles sécrétés par les cellules B en réponse à Leishmania infantum et leurs effets sur la réplication du VIH-1
... parasites Leishmania infantum and Leishmania ...with Leishmania infantum amastigotes resulted in upregulation of multiple cell surface activation markers and a strong dose-dependent secretion of ...
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Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63
... Results Leishmania major promastigotes impair the recruitment of LC3 to phagosomes in a GP63-dependent manner Growing evidence suggests that LAP contributes to augmenting the microbicidal and immune functions of ...
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No evidence of interspecific genetic exchange by multi-locus microsatellite typing between Leishmania Killicki and Leishmania Major in a mixed focus of cutaneous Leishmaniasis in Southeast Tunisia
... Copyright: ©2017 Harrabi M, et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, ...
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Novel insights into genome plasticity in Eukaryotes: mosaic aneuploidy in Leishmania
... Introduction Leishmaniasis is one of the world’s most neglected diseases, causing a broad spectrum of diseases (ranging from asymptomatic to lethal) in 98 countries on four continents. An estimated 350 million people are ...
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Implication des Galectines-3, 7 et 9 dans la réponse immunitaire contre le parasite Leishmania major
... de Leishmania sont maintenues en croissance dans un milieu SDM modifié et supplémenté avec 10% de FBS (Thermo Scientific), 5g/ml d’hémine (Sigma) ainsi que 100g/ml de pénicilline (Gibco), 100g/ml de ...
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