... protozoaire Leishmaniadonovani, un parasite qui infecte les macrophages du foie, de la rate et de la moelle ...traitée. Leishmania est transmis à l’humain par voie sanguine sous sa forme ...
... 1 Université de Lyon, Université Claude-Bernard Lyon I, ISPB-Faculté de Pharmacie, Lyon, France; 2 Institut de recherche pour le développement (IRD), UMR InterTryp IRD/CIRAD, campus international de Baillarguet, ...
... genus Leishmania totals approximately 20 described species causing human infections (reviewed in [2]) with a wide variety of clinical symptoms: cutaneous, visceral, mucocutaneous, mucosal and post-kala-azar dermal ...
... 2-Pyrone is an important class heterocyclic scaffold. Due to its pharmacophore properties, synthesis of hybrid derivatives bearing 2-pyrone moiety has attracted much attention; most of the compounds display strong ...
... reported to generate decreased antibody responses ( Pasare and Medzhitov, 2005; Kasturi et al., 2011 ). The role of B cell TLR signaling in antibody production has mainly been studied in models of autoimmune diseases. ...
... of Leishmaniadonovani, a protozoan parasite that grows in liver and spleen tissues after infection (called visceral leishmaniasis in South America and Mediterranean basin, and Kala Azar in South East ...
... Introduction Leishmaniadonovani and ...dogs. Leishmania is an intracellu- lar pathogen, whose establishment depends on its success- ful internalization and multiplication inside macrophages, its ...
... L. donovani strains from VL, PKDL and HIV/VL patients was examined using Ampli fied Fragment Length Polymorphism (AFLP), kDNA minicircle sequencing and Southern ...L. donovani 28S rRNA gene only minor ...
... Nous avons ensuite choisi des macrophages dérivés de la moelle osseuse (BMM) de souris BALB/c comme modèle d'infection. Les macrophages, traités ou non à l'IFN-y, ont ét[r] ...
... Finalement, nous avons aussi identifié sur le phagosome plusieurs protéines reconnues comme étant présentes dans les radeaux lipidiques de la membrane plasmique, telles que la flotiÏline[r] ...
... investigate the pathogenic diversity, the impact of the host genetic background and of the Leishmania genotypes, animal models are widely used. Classically, in infected animals, parasite-activated CD4 + T cells ...
... of Leishmaniadonovani or infantum infection with potential severe complications (cachexia, hepatic dysfunction, hemorrhages and - almost always without proper treatment - ...
... like Leishmaniadonovani and most foci of Leishmania tropica, parasites are trans- mitted from patients to patients by the bite of a ...that Leishmania will encouter will be during the ...
... and Leishmania (Leishmania) donovani belong to the species complex Leishmaniadonovani, while Leishmania (Leishmania) tropica and Leishmania (Leish- mania) major ...
... parasites Leishmania infantum and Leishmania ...with Leishmania infantum amastigotes resulted in upregulation of multiple cell surface activation markers and a strong dose-dependent secretion of ...
... Results Leishmania major promastigotes impair the recruitment of LC3 to phagosomes in a GP63-dependent manner Growing evidence suggests that LAP contributes to augmenting the microbicidal and immune functions of ...
... Introduction Leishmaniasis is one of the world’s most neglected diseases, causing a broad spectrum of diseases (ranging from asymptomatic to lethal) in 98 countries on four continents. An estimated 350 million people are ...
... de Leishmania sont maintenues en croissance dans un milieu SDM modifié et supplémenté avec 10% de FBS (Thermo Scientific), 5g/ml d’hémine (Sigma) ainsi que 100g/ml de pénicilline (Gibco), 100g/ml de ...