LC-High Resolution-MS
Histamine quantification in human plasma using High Resolution Accurate Mass LC-MS technology
... ACCEPTED MANUSCRIPT development of new methods presenting fewer disadvantages seems necessary. Methods using mass spectrometry are now commonly used in medical laboratories for quantification of drugs or metabolites. ...
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Développement de méthodes de dépistage des médicaments de contrefaçon et des produits adultérés par LC-MS/MS
... very high number of compounds in both methods and the knowledge that future analogues are always immerging on the market that could thus be present in samples, a targeted/untargeted LC-MS/MS ...
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Targeted Analysis of 46 Bile Acids to Study the Effect of Acetaminophen in Rat by LC-MS/MS
... chromatographic resolution of isomeric species using a mixture of 46 standard bile acids, and 14 isotopically-labeled internal standard (IS) compounds detected in multiple reaction monitoring (MRM) mode on a ...
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Quantitative metabolism of natural and antiviral nucleosides and nucleotides in human cells by LC-MS/MS
... the resolution between DXG and DAPD induc- ing quantification error due to signal ...rendering high throughput analysis of the clinical trial sam- ples ...
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LC–MS/MS-based quantification of efflux transporter proteins at the BBB
... Gröer et al. [ 7 ] and Zhang et al. [ 17 ] were the only authors dis- cussing the matrix effect. The first did not study it because they supposed that matrix effects are of minor importance because they used a long ...
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A database of high-resolution MS/MS spectra for lichen metabolites
... Jean-Luc Wolfender 5 , Harrie J. M. Sipman 6 , Robert Lücking 6 , Joël Boustie 1* & Pierre Le Pogam 4* While analytical techniques in natural products research massively shifted to liquid chromatography- mass ...
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Systematic Identification of Mitochondrial Proteins by LC−MS/MS
... complicated than the whole cell. This type of fractionation had the further advantage of enabling the assignation of unknown proteins to that organelle. Each SDS-PAGE gel slice represented a protein mixture further ...
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Dosage des catécholamines et des métabolites par LC-MS/MS
... •les catécholamines urinaires de 24 heures et plasmatiques •les métanéphrines urinaires de 24 heures et plasmatiques •les autres tests…. •L’imagerie par tomodensitométrie et RMN •L’image[r] ...
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Novel microcystins from Planktothrix prolifica NIVA-CYA 544 identified by LC-MS/MS, functional group derivatization and ¹⁵N-labeling
... identical LC–HRMS/MS product-ion ...and LC–HRMS/MS characteristics with reference materials of [d-Asp 3 ]MC-RR (1) and [d-Asp 3 ,Dhb 7 ]MC-RR (23) from NRC, showed that 1 from NIVA-CYA 544 ...
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Analyse des agents de chimiothérapie par extraction sur phase solide automatisée couplée à la chromatographie liquide et la spectrométrie de masse en tandem (SPE-LC-ESI-MS/MS)
... In this project, a method using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) preceded by an online solid-phase extraction (SPE) has been developed for the detection and ...
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Isotope-labelling derivatisation: a broadly applicable approach to quantitation of algal toxins by isotope dilution LC-MS/MS
... Extracts of ATXs in algae samples were dansylated directly prior to any sample clean-up. In this case the d 6 -dansylated ATX/hATX standard was spiked into the d 0 -dansylated sample reaction mixture immediately. ...
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mzDB: A File Format Using Multiple Indexing Strategies for the Efficient Analysis of Large LC-MS/MS and SWATH-MS Data Sets
... of LC-MS/MS runs, it there- fore becomes possible to efficiently extract the signals of all peptides with a m/z falling within a given “run slice” m/z ...to LC-MS acquisitions was first ...
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Development of a quantification method for up to 50 pesticides in honey and beeswax by LC-MS/MS and GC-MS detection
... Unfortunately, a common extraction solvents mixture and elution solvent is not yet optimized. The optimization of recoveries leads to water-acetone-NaCl 20% in the extraction solvent for LC-MS/MS ...
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Determination of dolutegravir's unbound fraction in human plasma using validated equilibrium dialysis and LC-MS/MS methods
... Version postprint ACCEPTED MANUSCRIPT Abstract Assessment of the unbound pharmacologically active fraction (fu; as the ratio of unbound to total concentration) of dolutegravir could improve therapeutic drug monitoring ...
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Determination of Galanin family peptides in LC-MS method using fused-core technology
... IN LC-MS METHOD USING FUSED-CORE TECHNOLOGY François Mansion, Jacques Crommen, Anne-Catherine Servais, Marianne Fillet * Laboratory of Analytical and Pharmaceutical Chemistry, Drug and Interfaculty Research ...
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High resolution SAR-image classification
... Exp. 6 This experiment demonstrates the result of β estimation from an exhaustive GT. The overall accuracy is lower, however like in Exp. 2, the inaccuracy of inaccuracy introduced by a manually created exhaustive GT is ...
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Comparison of approaches to deal with matrix effects in LC-MS/MS based determinations of mycotoxins in food and feed
... composition of both natural and labelled compounds by mass spectrometry (Gonzalez-Antuna et al., 2010). Taking into account the limited number of transitions that can be simultaneously measured by ...
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ProbMetab: an R package for Bayesian probabilistic annotation of LC-MS-based metabolomics
... We implemented a method to annotate compounds in a com- putational framework that allows the introduction of prior knowledge and additional spectral information. With the R package ProbMetab, we provide ways to summarize ...
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Clairance d'iohexol mesurée par LC-MS chez des sujets recevant une combinaison de substance de contraste iohexol-iodixanol
... Récemment plusieurs études ont suggéré l'utilisation de la mesure plasmatique d'un autre marqueur endogène: la cystatine C (pCys C), en vertu de sa grande fiabilit[r] ...
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An accurate and robust LC-MS/MS method for the quantification of chlorfenvinphos, ethion and linuron in liver samples
... ABSTRACT A generic method for the determination of linuron, chlorfenvinphos and ethion in liver samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is described. In vitro sample ...
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