Late-onset Alzheimer's disease
The PREVENT study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer's disease.
... Methods and analysis: PREVENT is a prospective cohort study examining biomarker status at mid-life in at least 150 individuals genetically at high, medium or low risk of late-onset AD. Participants are ...
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Early-onset and late-onset Alzheimer’s disease are associated with distinct patterns of memory impairment
... 1993); onset of symptoms ranging from 1 to 5 years prior to inclusion; no personal history of neurological or psychiatric disorder; no family history of AD that could suggest autosomal dominant inheritance; no ...
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Difference in imaging biomarkers of neurodegeneration between early and late-onset amnestic Alzheimer's disease
... Frisoni, G.B., Testa, C., Sabattoli, F., Beltramello, A., Soininen, H., Laakso, M.P., 2005. Structural correlates of early and late-onset Alzheimer’s disease: voxel based morphometric study. J. ...
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Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease.
... Heneka, M.T., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T., Van Leuven, F., 2005. Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition ...
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Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease
... Ceyzériat, K., Abjean, L., Carrillo-de Sauvage, M.A., Ben Haim, L., Escartin, C., 2016. The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway? Neuroscience 330, 205-218. Ceyzériat, ...
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Whole genome sequencing of late-onset Alzheimer's disease patients from genetic isolate.
... Alzheimer’s disease (AD) is a common heritable neurodegenerative ...common late-onset AD remain to be ...distantly-related late-onset AD patients from extra-large pedigree branches from ...
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The use of perceptual fluency in patients with Alzheimer disease: the role of expectation
... In normal subjects, enhanced perceptual fluency increased positive recognition responses when study and test stimuli were presented in the same sensory modality but not when stimuli we[r] ...
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Two Cases of Late-Onset Anti-NMDAr Auto-Immune Encephalitis After Herpes Simplex Virus 1 Encephalitis
... symptom’s onset revealed a lymphocytic pleiocytosis with 13 leukocytes/mm 3 and a more than 10 oligoclonal bands restricted to the CSF [type 2 according Anderson’s et ...
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Association of hypertension with coronary artery disease onset in the Lebanese population.
... with late CAD as outcome ...cardiovascular disease risks in ...the onset of cardiovascular ...vascular- disease severity over time, long-term β-blocker therapy was associated with a reduction ...
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Discovering novelty in sequential patterns: application for analysis of microarray data on Alzheimer disease
... Our contribution is three-fold: i We first help biologists select relevant sequences according to a specific topic and then to identify both popular genes often available in the literatu[r] ...
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Late-onset polyucosan body myopathy in five patients with a homozygous mutation in GYG1
... A late-onset severe form of GSD IV, dubbed as adult polyglucosan body disease (APBD), is characterized by central leukodystrophy, peripheral neuropathy, neurogenic bladder, and inconsistently ...
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Video Activity Recognition Framework for assessing motor behavioural disorders in Alzheimer Disease Patients
... Alzheimers disease show cognitive decline com- monly associated with psycho-behavioural disorders like depression, ap- athy and motor behaviour ...Alzheimer’s disease patients (AD)) participate to the ...
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Early onset and late acceleration of rapid exhumation in the Namche Barwa syntaxis, eastern Himalaya
... the late Miocene (8–10 ...Quaternary onset of rapid exhumation linked to a purely tectonic ...and late onset of rapid exhumation and suggests efficient coupling between tectonics and erosion ...
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Late-Onset OCD as a Potential Harbinger of Dementia With Lewy Bodies: A Report of Two Cases
... Methods and Results: We describe the clinical history of two patients that first showed OCD symptoms at an atypical age (>60 years). After several failed treatment attempts, they were hospitalized in our unit. Both ...
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Diagnosis of Neonatal Late-Onset Infection in Very Preterm Infant: Inter-Observer Agreement and International Classifications
... In adults, sepsis is no longer defined in reference to the systemic inflammatory re- sponse but as the dysfunction of at least one vital organ caused by a deregulated host response to infection [ 15 ]. The 2005 ...
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Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease
... METHODS After an alert in October 2019 from a patient presenting severe and persistent symptoms after taking DSF, the FFMVT (French Federation against Tick Borne Diseases) decided to launch two actions. One was a ...
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Brain correlates of performance in a free/cued recall task with semantic encoding in Alzheimer disease
... Alzheimer’s disease (AD) the brain correlates of free and cued recall performance using an adaptation of the procedure developed by Grober and Buschke ...Alzheimer’s disease of the cued recall performance ...
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Loss-of-function mutations in RAB39B are associated with typical early-onset Parkinson disease
... The patient with the RAB39B p.Trp186stop muta- tion had early disease onset (39 years) and typical par- kinsonism with asymmetric rest tremor, an akineto-rigid syndrome, and a good response to levodopa. He ...
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QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease
... mitochondrial disease and indicative of a limited capacity for mitochondria to respond to the metabolic challenge resulting from glycolysis limitation ( Lee et ...
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Three Gene-Targeted Mouse Models of RNA Splicing Factor RP Show Late-Onset RPE and Retinal Degeneration
... notype observed in patients with RNA splicing factor RP. We believe analyses of the transcriptomes of the RPE and retinas of the Prpf3-T494M, Prpf8-H2309P, and Prpf31-knockout mice will help identify the pathogenic ...
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