Internal ribosomal entry site
Targeted inhibition of the hepatitis C internal ribosomal entry site genomic RNA with oligonucleotide conjugates.
... Hepatitis C is a major public health concern, with an estimated 170 million people infected worldwide and an urgent need for new drug development. An attractive therapeutic approach is to prevent the ‘cap-independent’ ...
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A single internal ribosome entry site containing a G quartet RNA structure drives fibroblast growth factor 2 gene expression at four alternative translation initiation codons.
... The integrity of stem-loop II is required for IRES activity To test the structure of stem-loop II more thoroughly, we generated deletions and mutations in this region in the context of bicistronic luciferase construct ...
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Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA.
... by SDS-PAGE. Colloidal blue staining of the gel revealed that several proteins were specifically retained by each RNA (Fig. 2B). The protein bands that appeared selectively purified on the EMCV RNA or FGF-2 RNA columns ...
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Comparison of AIM, Entry Standard and AlterNext
... and Entry Standard were created almost at the same time in ...and Entry Standard were created, some companies that were at the time listed on the “Marche Libre” of France and “Neuer Markt” of Germany were ...
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Endogenous Entry, Product Variety and Business Cycles
... about entry, pro…ts, and ...since internal increasing returns are inconsistent with perfect competition, one needs to adopt the ad hoc assumption of a labor externality in the consumption sector to avoid ...
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Live or let die : intra-sectoral lobbying on entry
... an entry tax and a vector of tariffs, we keep the same framework they have used for the political ...an entry tax in a given sector with no specific inputs instead of a lobbying activity on tariffs in a ...
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Access Pricing and Entry in the Postal Sector
... 1 Introduction This paper concentrates on the ongoing liberalization process of the postal sector in the European Union. It focuses in the entry of new postal operators on the downstream segments of the postal ...
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Ribosomal RNA genes shape chromatin domains associating with the nucleolus
... organization Ribosomal RNA (rRNA) genes are organized as tandem repeats in specific genomic regions named nucleolus organizer regions (NORs) by CONTACT Frédéric Pontvianne ...
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Analytical and theoretical extensions of double entry
... DEWEY LIBRARY.. Recent analysis has revealed that double entry can be represented analytically as two separate partitionings of the same finite point set. One natural con- sequence of th[r] ...
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Advertising and entry deterrence : an exploratory model
... that in the presence of economies of scale, an established monopoly facing the threat of entry might find it possible and optimal to deter that entry credibly by Investing more in durabl[r] ...
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Sharing of mitotic pre-ribosomal particles between daughter cells.
... of ribosomal genes (rDNAs) is progressively repressed during prophase and maintained repressed in a cyclin-dependent kinase (CDK)1 –cyclin-B- dependent manner until telophase (Sirri et ...as ribosomal ...
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Dynamics of Dowstream Entry in Postal Markets
... of entry in the postal sector We will consider a situation similar to Hori and Mizuno (2006) where the mail demand faced by the entrant is growing over ...no entry, access and ...
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Enabling rapid development of multimodal data entry applications
... data entry to a couple of hours by a novice user as compared to months previously required for development of the same application by an experienced ...date entry in a particular context, but do not have ...
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Claudins in viral infection: from entry to spread
... One possible limitation for CLDN1-directed therapies is escape via CLDN6 or CLDN9 on hepatocytes. Indeed, CLDN1-specific antibodies only partially inhibited infection by HCV strains with broad CLDN tropism in ...
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Global types with internal delegation
... the internal choice of outputs in Clause 1 above, the choice leader can freely choose any of its branches; as formalised by the universal quantification over ...distinguish internal and external choice, are ...
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Nanovoids coalescence by internal necking
... Theoretical estimates for the onset of coalescence of nanoscale voids in anisotropic plastic matrix have been obtained based on limit analysis and homogenization, under both axisym- me[r] ...
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Internal Calculi for Separation Logic
... an internal Hilbert-style axiomatisation for SL(∗, −∗), we go beyond this, and we propose a method to axiomatise other separation logics assuming that key properties are ...
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Types are internal infinity-groupoids
... Abstract—By extending type theory with a universe of defini- tionally associative and unital polynomial monads, we show how to arrive at a definition of opetopic type which is able to en[r] ...
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Coordination of origin licensing and cell cycle entry
... Key conclusions In this thesis I address the question of how cells ensure that the capacity to replicate has been established prior to S-phase in two systems. In cycling cells, I show that a novel yeast gene, YOR006C, ...
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Multimodal Field Data Entry: Performance and Usability Issues
... MULTIMODAL FIELD DATA COLLECTION To facilitate efficient field data collection and timely decision making – especially in the case of field quality control inspection – it would be highly beneficial to use multimodal ...
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