Interleukin 1 Receptor antagonist (IL-1ra)
Production of interleukin-1 receptor antagonist by human articular chondrocytes.
... Abstract Interleukin-1 receptor antagonist (IL-1Ra) is a natural IL-1 inhibitor possessing anti-inflammatory properties. IL-1Ra is produced as different isoforms, one ...
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The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.: PPARalpha controls the expression of the sIL-1ra in liver
... IL-1 receptor antagonist While many genes involved in inflammation were down-regulated by Wy14643, hepatic expression of Interleukin 1 receptor antagonist (IL-1ra) ...
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Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism
... cellular activation. Based on previous studies on the human IL-1Ra promoter, one can suggest that rosiglita- zone could have affected alternate IL-1–sensitive trans- acting factors such as CCAAT/enhancer ...
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Interleukin-1 Family Cytokines: Keystones in Liver Inflammatory Diseases
... related receptor), another receptor of the IL-1 family, has no known ligands but transduces Abbreviations: AID, induced cytidine deaminase; ACLF, HBV acute-on-chronic liver failure; ALD, alcoholic ...
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Long-term effectiveness and safety of interleukin-1 receptor antagonist (anakinra) in Schnitzler's syndrome: A French multicenter study.
... U SC R IPT of prednisone). However, the outcome was fatal in two cases and it cannot be stated whether the same would have occurred in the absence of blocking IL-1Ra. On the other hand, pursuing high dose ...
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Distinct expression of interleukin (IL)-36 α, β and γ , their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease
... The interleukin (IL)‐1 family of cytokines includes seven agonists (IL‐1α, IL‐1β, IL‐18, IL‐ 33, IL‐36α, IL‐36β and IL‐36γ) and four members with established or hypothetical antagonist or ...
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Shuttle-Cargo fusion molecules of transport peptides and the hD 2/3 receptor antagonist fallypride : a feasible approach to preserve ligand-receptor binding?
... fallypride moiety in the resulting fusion drugs. Furthermore, the influence of linker structures and lengths between the peptide carrier and the receptor ligand was systematically evaluated. Synthesis of ...
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Tocilizumab Contributes to the Inflammatory Status of Mature Dendritic Cells through Interleukin-6 Receptor Subunits Modulation
... In this study, we showed that tocilizumab had no effect on LPS-induced IL-6 secretion in human matured DCs. This point is of utmost importance because it suggests that DCs could remain a significant source of IL-6, ...
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Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1
... (5 g/ml) along with pSG5-rPR (0.5 g/ml) and increasing amount of pSG5-His 6 -SUMO-1 expression vector. The cells were treated 24 h before harvesting with 10 n M R5020 (●), 10 n M RU486 (f), 100 n M ZK98299 (䡺), ...
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Characterization of binding sites of a new neurotensin receptor antagonist, [3H]SR 142948A, in the rat brain.
... antagonist can counteract the effects of neurotensin in numerous in vitro and in vivo assays (Gully et al., 1993); however, SR 48692 is unable to inhibit neurotensin-induced hypothermia and analgesia in rats and ...
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The beta adrenergic receptor antagonist propranolol alters mitogenic and apoptotic signaling in late stage breast cancer
... appropriate 1:1000 HRP-conjugated second- ary antibody, subjected to Supersignal West Dura Extended Duration Substrate (ThermoFisher Scientific), and digitally captured using a GE Image Quant Las4000 imaging ...
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A dual thromboxane inhibitor and thromboxane receptor antagonist prevents pig myocardial infarction induced by coronary thrombosis
... Methods: Experiments were performed on 12 healthy pure pietran anaesthetised pigs of either sex weighing from 20 to 30 kg. After a 30 min stabilisation period, a tissue strip saturated with ferric chloride solution (50% ...
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The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma
... 2.2. Patients Both female and male patients between 18 and 50 year old with stable mild-to-moderate asthma were eligible for the trial. All patients gave written informed consent before entering the trial. Patients were ...
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Thromboxane–prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats
... prostaglandin receptor, Cerebral vasospasm, Blood brain barrier, Apoptosis, Background Most survivors of a cerebral aneurysm rupture experi- ence subarachnoid haemorrhage (SAH)-related morbid- ity and mortality, ...
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Cannabinoid-1 receptor antagonists in type-2 diabetes.
... CB1-receptor antagonist rimonabant 20 mg in patients with type-2 diabetes; multiple favourable effects comprise effective weight loss, reduced abdominal adiposity, a clinically significant reduction in ...
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Current concepts regarding the HTLV-1 receptor complex.
... Three Receptor Molecules: GLUT1, HSPG and NRP-1 The glucose transporter GLUT1 It was not until 2003 that work from Sitbon and Batti- ni’s laboratory identified a candidate that matched all the prerequisites ...
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Tolerance and efficacy of off-label anti-interleukin-1 treatments in France: a nationwide survey
... Methods: Physicians answered a questionnaire that covered patient and disease data, anti –IL-1 agent use, efficacy and adverse events. The study involved adult or paediatric patient who had received an anti ...
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Ciproxifan, a Histamine H 3 -Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of Haloperidol in the Rat
... dopamine receptor gene ex- pression in the rat striatum: sensitive cRNA probes demonstrate prom- inent segregation of D1 and D2 mRNAs in distinct neuronal popula- tions of the dorsal and ventral ...
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Role of interleukin-1 in the pathogenesis of the infection caused by Streptococcus suis serotype 2
... 62 mechanisms. However, the cellular activation leading to IL-1β production was similar for strains P1/7 and SC84, indicating that the recognized components are relatively well-conserved between these two strains, which ...
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L'impact des perturbations du cytosquelette sur l'expression et la fonction de la low-density lipoprotein receptor-related protein 1 (LRP-1)
... T he cytoskeleton ' s role is integral to alm ost every cellul ar function: it i s the structure that gives cells their shape , mediates the controll ed movement o[r] ...
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