Interleukin-1 receptor antagonist
Production of interleukin-1 receptor antagonist by human articular chondrocytes.
... Abstract Interleukin-1 receptor antagonist (IL-1Ra) is a natural IL-1 inhibitor possessing anti-inflammatory properties. IL-1Ra is produced as different isoforms, one secreted (sIL-1Ra) ...
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The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.: PPARalpha controls the expression of the sIL-1ra in liver
... IL-1 receptor antagonist While many genes involved in inflammation were down-regulated by Wy14643, hepatic expression of Interleukin 1 receptor antagonist (IL-1ra) was ...
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Long-term effectiveness and safety of interleukin-1 receptor antagonist (anakinra) in Schnitzler's syndrome: A French multicenter study.
... U SC R IPT From a clinical standpoint, all of the patients had an active disease at the point of IL1Ra introduction (Figure 1). All of them suffered recurrent or chronic skin rash, and 22 had severe extracutaneous ...
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Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism
... Therefore, we studied the ability of 2 PPAR agonists, the natural low binding–affinity compound 15-deoxy-PGJ 2 and the synthetic high binding–affinity TZD rosiglitazone, to modulate IL-1Ra in rat synovial fibroblasts ...
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Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1
... F IG . 5. SUMO-1 expression enhances PR-SRC-1 interaction in vivo. The effect of SUMO-1 on the formation of PR-SRC-1 complexes was analyzed by the two-hybrid system in CV-1 cells. The ...
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Tocilizumab Contributes to the Inflammatory Status of Mature Dendritic Cells through Interleukin-6 Receptor Subunits Modulation
... In this study, we showed that tocilizumab had no effect on LPS-induced IL-6 secretion in human matured DCs. This point is of utmost importance because it suggests that DCs could remain a significant source of IL-6, ...
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Shuttle-Cargo fusion molecules of transport peptides and the hD 2/3 receptor antagonist fallypride : a feasible approach to preserve ligand-receptor binding?
... known P-gp inhibitor cyclosporine A as an internal positive control. In this assay, we studied the most promising hybrid molecules, 9, 13, 21, and 22, as well as their native peptide lead structures 27, AngioPep-2, and ...
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Characterization of binding sites of a new neurotensin receptor antagonist, [3H]SR 142948A, in the rat brain.
... 1. Introduction Neurotensin is a 13-amino acid neuropeptide found in the central nervous system and peripheral tissues of numerous mammalian species (Emson et al., 1982; Mai et al., 1987). Neurotensin acts as a ...
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The beta adrenergic receptor antagonist propranolol alters mitogenic and apoptotic signaling in late stage breast cancer
... Conclusion: Collectively, these data provide support for the incorporation of b-AR antago- nists into the clinical management of breast cancer, and elucidate a partial molecular mechanism explaining the efficacy of b-AR ...
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The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma
... Neurokinin A (NKA), Neurokinin B (NKB) and substance P are members of the tachykinin peptide family. They are present in sensory nerves and in immune cells [1]. SP binds preferentially on the tachykinin NK ...
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A dual thromboxane inhibitor and thromboxane receptor antagonist prevents pig myocardial infarction induced by coronary thrombosis
... thromboxane receptor antagonist prevents pig myocardial infarction induced by coronary thrombosis ...Rolin 1 , ...Masereel 1 . 1 University of Namur, Department of Pharmacy, Namur, ...
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Cannabinoid-1 receptor antagonists in type-2 diabetes.
... year 1 were analysed using analysis of covariance with weight loss as a ...year 1 on HDL-C, triglycerides, fasting insulin and insulin resistance was due to a direct effect not attributable to weight ...
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Thromboxane–prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats
... TP receptor activation leads to platelet or endothelial cell activation, smooth muscle cell contraction [ 15 ], endothelin-1 production and leucocyte recruitment [ 16 ...(TP) receptor agonists in a ...
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Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
... Department of Neurodegenerative Diseases and Geropsychiatry/Neurology, University of Bonn Medical Center, Bonn, Germany Edited by: Detlev Boison, Legacy Health, United States Reviewed by: Annakaisa Haapasalo, A.I. ...
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Tolerance and efficacy of off-label anti-interleukin-1 treatments in France: a nationwide survey
... Methods: Physicians answered a questionnaire that covered patient and disease data, anti –IL-1 agent use, efficacy and adverse events. The study involved adult or paediatric patient who had received an anti ...
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Ciproxifan, a Histamine H 3 -Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of Haloperidol in the Rat
... lin mRNA expression elicited by haloperidol in the rat striatum. Top, The proenkephalin mRNAs were visualized by in situ hybridization on films 3 hr after intraperitoneal administration of saline solution (CONTROL), ...
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Role of interleukin-1 in the pathogenesis of the infection caused by Streptococcus suis serotype 2
... 62 mechanisms. However, the cellular activation leading to IL-1β production was similar for strains P1/7 and SC84, indicating that the recognized components are relatively well-conserved between these two strains, which ...
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L'impact des perturbations du cytosquelette sur l'expression et la fonction de la low-density lipoprotein receptor-related protein 1 (LRP-1)
... T he cytoskeleton ' s role is integral to alm ost every cellul ar function: it i s the structure that gives cells their shape , mediates the controll ed movement o[r] ...
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Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.
... Material and Methods Animals PAR-1-deficient mice were established by Connolly et al (9) and were studied in the C57BL/6 background. We used only male animals, aged 10-12 weeks, and weighing 31.0 ± 2.5 g at the ...
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Current concepts regarding the HTLV-1 receptor complex.
... Targeting DC and interfering with NRP-1 signalling might have several other consequences on viral infec- tion. HTLV-1 infection results in a depletion of myDC as well as pDC and an impairment of their ...
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