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Insulin signalling

Jejunal Insulin Signalling Is Increased in Morbidly Obese Subjects with High Insulin Resistance and Is Regulated by Insulin and Leptin

Jejunal Insulin Signalling Is Increased in Morbidly Obese Subjects with High Insulin Resistance and Is Regulated by Insulin and Leptin

... of insulin resistance [ 27 , 28 ], although there are contradictory results [ 28 ...in insulin resistance of intestinal enterocytes has been shown in morbidly obese subjects [ 29 ...intestinal ...

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Hyperinsulinemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma

Hyperinsulinemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma

... patients, insulin-resistant patients and humans with liver steatosis ...some insulin signalling pathways. Interestingly, insulin has been recently identified as a negative regulator of PTEN ...

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Stress exposure alters brain mRNA expression of the genes involved in insulin signalling, an effect modified by a high fat/high fructose diet and cinnamon supplement

Stress exposure alters brain mRNA expression of the genes involved in insulin signalling, an effect modified by a high fat/high fructose diet and cinnamon supplement

... of insulin signals, factor 2 and 3 are related to insulin signalling linked to oxidative signalling control [ 56 ] and factor 4 is related to nutrient homeostasis [ 57 ...

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Alterations of insulin signalling in type 2 diabetes: A review of the current evidence from humans

Alterations of insulin signalling in type 2 diabetes: A review of the current evidence from humans

... PI3K signalling is actually dysregulated in insulin resistance and type 2 ...insulin signalling. Indeed, the involvement of class II PI3Ks in insulin signalling, in cultured ...

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Hypoglycaemia revealing heterozygous insulin receptor mutations.

Hypoglycaemia revealing heterozygous insulin receptor mutations.

... A insulin resistance (IR) syndromedue to dominant- negative heterozygous mutations in the insulin receptor gene (INSR) ...withdecreased insulin clearance was suggested torescue genetically-altered ...

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Environmental sensitivity of the C. elegans vulval signalling network

Environmental sensitivity of the C. elegans vulval signalling network

... sensory signalling mediated by Insulin and TGF-  signalling and, as suggested by Braendle & Félix (2008), acts the level or upstream of ...MPK-1/MAPK signalling, yet had no effect on ...

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AMP-Activated Protein Kinase Signalling

AMP-Activated Protein Kinase Signalling

... increase insulin sensitivity for improved glucose uptake in skeletal muscle is also a promising key therapeutic strategy to treat ...the insulin-sensitizing effect of the widely used AMPK activator ...

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Adjusting insulin doses : from knowledge to decision

Adjusting insulin doses : from knowledge to decision

... your insulin dose while your blood glucose levels are ...of insulin injected in the ...the insulin doses: they do not test your knowledge, but what you do ...of insulin which covers the period ...

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Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance

Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance

... brain insulin resistance (defined as a decrease in brain IR activity and sensitivity) [ 182 ...reduced insulin-stimulated phosphorylation of the IR and decreased total AKT and total GLUT4 protein ...

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18F labelling of Insulin via click chemistry

18F labelling of Insulin via click chemistry

... J.Paris@ulg.ac.be As an initial step, native insulin had to be de- rivatized in order to present an accessible alkyne group at an appropriate position. For this, two of the three amino functions available on the ...

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Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.

Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.

... in insulin resistance (8). For example, prolonged insulin treatment reduces the level of IRS-1 through proteasome dependent process (47, 48) whereas osmotic (49) or oxidative (50) stresses induce IRS-1 ...

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Different initiation of pre-TCR and γδTCR signalling

Different initiation of pre-TCR and γδTCR signalling

... SCB.29 cell lines have been described 4 . After adhesion on poly- L -lysine coated coverslip, the cells were ®xed in paraformaldehyde and incubated on ice for 45 min with antibodies in PBS, 3% fetal calf serum (FCS) and ...

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Macrophage plasticity is Rac signalling and MMP9 dependant

Macrophage plasticity is Rac signalling and MMP9 dependant

... Using in vivo imaging we showed that macrophages exhibited morphological plasticity during 118.. their migration.[r] ...

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Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion

Follow-up of GK rats during prediabetes highlights increased insulin action and fat deposition despite low insulin secretion

... body insulin sensitivity to those of GK pups reared with their own diabetic GK ...induced insulin secretion in vivo (data not shown), suggest- ing that individuals with genetically low risk could increase ...

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Does signalling pathways inhibition hold therapeutic promise for osteoarthritis?

Does signalling pathways inhibition hold therapeutic promise for osteoarthritis?

... Osteoarthritis was long viewed as a degenerative joint dis- ease characterized by gradual cartilage attrition. Mechanical factors were very often incriminated and patient management limited to pain control. Subsequently, ...

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Analysis of In Vitro Insulin-Resistance Models and Their Physiological Relevance to In Vivo Diet-Induced Adipose Insulin Resistance

Analysis of In Vitro Insulin-Resistance Models and Their Physiological Relevance to In Vivo Diet-Induced Adipose Insulin Resistance

... It is not surprising that no single in vitro model captures all the features of DIO adipose insulin resistance, which are compli- cated phenotypes depending on multiple factors (e.g., mouse strain, high-fat diet ...

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REDO RSVP: Efficient signalling for multimedia in the Internet

REDO RSVP: Efficient signalling for multimedia in the Internet

... from scalability problems as the number of flows with reservations increases. Al- though this rules out their use within the core of the network, per-flow provision- ing can still be used at the edge of the network ...

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View of Implications of Striatal Dopamine Signalling for Schizophrenia

View of Implications of Striatal Dopamine Signalling for Schizophrenia

... Recent studies have demonstrated significant variation in DA signalling across the striatum. The striatum is a subcortical structure in the midbrain that modulates neuronal input to the basal ganglia. It consists ...

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A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance

A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance

... by insulin We next sought further proof that the two signaling pathways are indeed ...investigated insulin- and serum-induced GLUT4 translocation in the presence of inhibitors of various signaling molecules ...

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BMP signalling controls the construction of vertebrate mucociliary epithelia

BMP signalling controls the construction of vertebrate mucociliary epithelia

... BMP signalling is required to activate dll1 expression in the Xenopus developing epidermis, although the absence of clear Smad consensus binding sites upstream of the dll1 open reading frame (data not shown) ...

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