Insulin-like growth factor type 1 receptor (IGF-1R)
Modulation of Endothelin-1 and Insulin-like Growth Factor Type 1-induced Signaling by Curcumin in A-10 Vascular Smooth Muscle Cells
... kinase 1 and 2 (ERK1/2) pathways, as well as an increase in ET-1-mediated VSMC hypertrophy and ...and insulin-like growth factor type 1 receptor ...
133
Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury.
... Overall, IGF-1R neo/- mice were more resistant to hyperoxic stress than littermate controls ...of IGF-1R in response to high oxygen concentration [11,14], directly implicate ...
12
Altered expression of type I insulin-like growth factor receptor in Crohn's disease
... the IGF system may have a role in smooth muscle cell hyperplasia of the muscularis propria, which is a prominent feature of CD intestinal ...for IGF-1R null mutant gene have generalized organ ...
9
Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout
... and growth factors, and generally restores most of the initial liver mass in less than a week in the wild-type ...necrosis factor (TNF) α receptor I (3) or interleukin-6 (IL-6) (4) revealed ...
38
Characterization of the Insulin-Like Growth Factor Axis in the Human Thymus
... and IGF-1R mRNAs in human TEC primary cultures, Jurkat T-cell line and human liver or placenta as positive ...and IGF-1R cDNAs ...and 1 week for ...of type-1 IGF ...
6
Characterizing and engineering antibodies against the epidermal growth factor receptor
... receptor and inhibited cell growth, but it did not bind to or inhibit cells expressing normal EGFR levels ...the receptor in cells overexpressing EGFR ...blocking receptor ...
156
Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation
... epidermal growth factor receptor (EGFR) plays a crucial role in GBM pathogenesis ...wild type EGFR (EGFR WT ) and its ligands are over expressed and activated in >65% of GBM tumors ...the ...
19
Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)
... Expression of Wild-Type and Chimeric mRNAs. Northern blot analysis of human tissues showed that the FIM gene is ubiquitously expressed as two main transcripts of 5.0 and 7.5 kb (Fig. 5a). Additional transcripts ...
7
Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation.
... by insulin-mediated INSR activation 30 INSR ...express IGF-1R . In a previous work, we found 4 IGF-1R gene is expressed in 35 and 50 of primary myeloma cells in 2 large series of newly ...
15
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.
... phosphorylation (35). Moreover, the effect of IL-1 is clearly different from the TNF effect that promotes a rapid inhibition of IRS-1 tyrosine phosphorylation through its serine phosphorylation (11, ...
30
Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses
... CD4 1 T cells (1 3 10 5 ) from recipients were subjected in vitro to secondary challenge (mixed leukocyte reaction [MLR]) with T-cell –depleted splenocytes (1 3 10 5 ) from na¨ ıve ...CD4 1 T ...
13
Persistent infection of thymic epithelial cells with coxsackievirus B4 results in a decreased expression of insulin-like growth factor 2
... of insulin gene transcription in healthy murine and human thymus had already been described and correlated to the poor tolerogenicity of insulin protein evidenced in many stud- ies ( 20 ...transcripts. ...
13
Dissociation of increases in plasma insulin-like growth factor I and testosterone during the onset of puberty in bulls
... (a) insulin-like growth factor-binding protein-3 (IGFBP-3) and (b) IGFBP-2 in (O) control, (·) testosterone propionate-treated and ( ) GnRH-treated groups during the onset of ...
8
Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1.
... or IGF-1. In the four cell lines, Mcl-1 was the only anti-apoptotic protein whose expression dramatically decreased when cells were IL-6 ...adding IGF-1, as potent a survival ...
31
PKB mediates Insulin-Like Growth Factor 1-induced phosphorylation and nuclear export of Histone Deacetylase 5 via NADPH Oxidase 4 activation in vascular smooth muscle cells
... L’Insulin-like growth factor-1 (IGF-1) est un peptide vasoconstricteur qui joue un rôle proéminent dans la progression des maladies cardiovasculaires, grâce à la génération ...
118
Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.
... and insulin-like growth factor-1 (IGF1) are growth factors known to promote non-small cell lung cancer (NSCLC) ...that 1) AR and IGF1, secreted by H358 NSCLC cells, ...
18
Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency
... (Fig. 1). The intra-assay coef®cients of variation were 5´1, 3´0 and 5´5%, for samples with PGH concentrations of 20´5, 49´5 and 73´5 mg/l (low, medium and high), respectively; the interassay coef®cients of ...
3
Expression de l’early growth response protein-1 (Egr-1) par le peroxyde d’hydrogène (H2O2) nécessite l’activation de l’IGF-1R, de c-Src et de PKC dans les CMLV
... La voie de signalisation de la PKC est impliquée dans l’expression de l’Egr-1 induite par le H 2 O 2 comme en fait foi son inhibition par différents agents pharmacologiques. Dans la prolifération des fibroblastes ...
110
Cannabinoid-1 receptor antagonists in type-2 diabetes.
... with type- 2 diabetes and a high risk of cardiovascular disease deserves ...with type-2 diabetes; multiple favourable effects comprise effective weight loss, reduced abdominal adiposity, a clinically ...
13
en fr Crosstalk between estrogen receptor alpha and the growth factor IGF-I in the transcriptional activation of breast cancer cell lines Dialogue entre le recepteur des oestrogènes alpha et le facteur de croissance IGF-I dans l'activation transcriptionnelle des cellules cancéreuses mammaires
... that growth factors induce a change in ER ␣ phosphorylation directly via the acti- vation of mitogen-activated protein kinase and/or AKT ...by IGF- I-is sufficient to directly induce ER␣ binding to the ERE ...
184