Innate immune
Differential Susceptibility and Innate Immune Response of Aedes aegypti and Aedes albopictus to the Haitian Strain of the Mayaro Virus
... 3.2. Innate Immune Response to Mayaro Virus Infection We analyzed the expression levels of twenty genes known to be involved in the immune response of mosquitoes in the midgut of MAYV-infected ...
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A Shift from Cellular to Humoral Responses Contributes to Innate Immune Memory in the Vector Snail Biomphalaria glabrata
... invertebrate innate immune memory have been mainly phenomenological and based on ecological or phenotypic studies, and little work has addressed the potential molecular and cellular mechanisms underlying ...
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Raised interferon beta, type 3 interferon and interferon stimulated genes - evidence of innate immune activation in neutrophilic asthma.
... The purpose of this study is to determine whether the severity of asthma or a specific cellular sputum pattern may be linked to evidence of innate immune activation. Here we have examined sputum samples ...
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Modulation of innate immune signaling by a Coxiella burnetii eukaryotic-like effector protein
... Modulation of innate immune signaling by a Coxiella burnetii eukaryotic-like effector protein.. Melanie Burette, Julie Allombert, Karine Lambou, Ghizlane Maarifi, Sébastien Nisole, Eliza[r] ...
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Innate immune response of primary human keratinocytes to West Nile virus infection and its modulation by mosquito maliva
... Montpellier, Montpellier, France, 4 MIVEGEC UMR 224, Université de Montpellier, IRD, CNRS, Montpellier, France West Nile Virus (WNV) is a flavivirus involved in many human infections worldwide. This arthropod-borne virus ...
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The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3.
... The innate immune response constitutes the first line of defence and plays an important role in the detection of invading pathogens therefore limiting the spread of infectious ...The innate ...
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Diversity of innate immune cell subsets across spatial and temporal scales in an EAE mouse model
... all immune cells contained in SC and brain during ...the immune response and the degree of heteroge- neity found in the innate immune cell populations during EAE progression, we performed ...
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Candidate innate immune system gene expression in the ecological model Daphnia
... Tracking genetic change over time can be greatly augmented by identifying key genes of the infection process, and in particu- lar genes whose sequence polymorphisms are linked to variation in susceptibility. This should ...
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Innate immune cells and their contribution to T-cell-based immunotherapy
... adaptive immune system to recognize and eliminate the fret and it predisposes patients to a higher risk of infection and tumor ...the innate immune compartments. Notably, the expansion of the ...
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Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune Response
... the innate immune response that enables the organism to protect itself against the proliferation of damaged ...to innate immunity activation by pro-inflammatory paracrine effects, highlighting the ...
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β2-adrenergic signals downregulate the innate immune response and reduce host resistance to viral infection
... Here, we dissect the role of the β2-AR pathway in controlling early immune responses and resistance to mouse CMV (MCMV). MCMV is commonly used as a model of human CMV infection. The initial cytokine response to ...
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Proximity Ligation Assays for In Situ Detection of Innate Immune Activation: Focus on In Vitro-Transcribed mRNA
... 1 Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, UA Whitaker Building, Atlanta, GA 30332, USA; 2 CureVac, Paul-Ehrlich-Straße 15, 72076 ...
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Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones
... human innate immune system restriction factor MxA [ 9 , 16 ], a feature that critically enhanced the pathogenicity and fitness of the 1918 pandemic influenza ...
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A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system
... The oral route is the natural route of Listeria infection. We thus also orally infected human E-cadherin (hEcad) transgenic mice, which are permissive to Listeria oral infection (18), and monitored bacterial counts in ...
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Innate Immune Response to Streptococcus pyogenes Depends on the Combined Activation of TLR13 and TLR2
... Discussion Microbes colonizing surface tissues of complex multicellular organisms consist of harmless species as well as of species capable of converting into invading pathogens, when the surface barrier function is ...
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The mitochondrial respiratory chain: A metabolic rheostat of innate immune cell-mediated antibacterial responses
... The mitochondrial respiratory chain: A metabolic rheostat of innate immune cell-mediated antibacterial responses... 7 8 2 INSERM U1211, Rare Diseases, Genetics and Metabolism, Universi[r] ...
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Overlapping Podospora anserina transcriptional responses to bacterial and fungal non self indicate a multilayered innate immune response
... Overlap- ping Podospora anserina transcriptional responses to bacterial and fungal non self indicate a mul- tilayered innate immune response... Saupe 1 , Mathieu Paoletti 1*.[r] ...
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Attacking tumor cells with a dual ligand for innate immune receptors.
... Attacking tumor cells with a dual ligand for innate immune receptors Johan Garaude and J. Magarian Blander Nod-like receptors (NLRs) are being implicated in an increasing number of biological processes ...
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Epigenetic regulation of innate immune responses to infection
... In contrast to histone modifications, little is known about the regulatory implications of DNA methylation in innate immune responses. DNA methylation has historically been considered to be a relatively ...
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Lipoglycans Contribute to Innate Immune Detection of Mycobacteria
... Innate immune detection of mycobacteria involves several PRRs that cooperate to mediate both uptake of the bacilli into host cells and activation of intracellular signaling cascades that signal the presence ...
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