innate CD8(+) T cells
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Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases
... inKt/innate Cd8(+) t-cell axis hypothesis in chronic myeloid leukemia ...stem cells (HSC) generate normal immune ...dendritic cells (DCs) to iNKT cells. We propose that activated iNKT ...
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en fr Characterization of innate memory CD8 T cells using new biomarkers Identification de nouveaux biomarqueurs permettant la caractérisation des lymphocytes T CD8 mémoires innés
... Acide DésoxyRibonucléique AutoImmune REgulator Activator Protein 1 Antigen Presenting Cells Altered Peptide Ligands Acide RiboNucléique messager Adénosine Triphosphate Complexe Majeur d’[r] ...
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The Hypothesis of the Human iNKT/Innate CD8(+) T-Cell Axis Applied to Cancer: Evidence for a Deficiency in Chronic Myeloid Leukemia
... the innate CD8(+), T cell pool is in line with our hypothesis that this new subset may be involved during tumorigenesis in ...of innate CD8(+) T cells in humans, such as rapid ...
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Visualizing early splenic memory CD8+ T cells reactivation against intracellular bacteria in the mouse
... that innate cells such as neutrophils and inflammatory monocytes expressing the myeloid marker Ly-6C -also defined as TNF/NO- producing DCs (Tip-DCs)- produce antimicrobial mediators known to be critical ...
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Involvement of CD8+ T Cells in Multiple Sclerosis
... these cells are mucosal-associated invariant T (MAIT) cells. MAIT cells are a subset of innate effector memory T cells bearing a semi-invariant TCR ...MAIT cells are present in ...
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A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4+ and CD8+ T Cells
... Dendritic cells are professional antigen presenting cells that play fundamental roles at establishing and regulating immune responses at the interface of innate and adaptive immunity ( 63 ...these ...
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IL-12 Signaling Contributes to the Reprogramming of Neonatal CD8+ T Cells
... neonatal CD8 + T cells that were specifically repressed by TCR/IL-12 stimulation (Figure ...the innate immune response (Figure 5C), such as the metalloprotease gene MPO and DEFA4, associated with ...
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Natural killer cells promote early CD8 T cell responses against cytomegalovirus
... antiviral CD8 T cell responses, and, therefore, that excessive levels of IFN-a can have a direct negative impact on antiviral immune cell responses in a manner that is independent of the level of viral replication ...
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en fr [The CD8+ T cell innate function in the war against cancer]. Les fonctions innées des lymphocytes T CD8 dans la lutte contre le cancer
... natural killer T cells », découvertes au début des années 1990. Elles possèdent un TCR semi-invariant reconnaissant des antigènes glycolipidiques présentés par la molécule non classique du complexe majeur ...
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Attacking tumor cells with a dual ligand for innate immune receptors.
... We tested this possibility by introducing lagellin into different tumor cell lines, a strategy that abrogated tumor development upon subcutaneous or intravenous injection of these lagellin-expressing cells, and ...
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Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells
... T Cells and Differentiation of CD103 + T Cells We next aimed to understand the immunological function of DC3s and to compare it with cDC2s and ...activated cells, we found that overnight activa- tion ...
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CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells
... T cells that do not express either CD4 or CD8 co-receptor provided proof-of-concept for MHC-independent modes of T cell activation (Porcelli et ...(iNKT) cells recognize lipids presented by cluster ...
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Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells
... B cells accumulate in the blood and exhibit a phenotype similar to BL with type I EBV infection (Hochberg et ...NK cells, CD4 T cells, CD8 T cells, B cells, iNKT cells, V ...
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Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
... + CD8 + TILs, our data show that checkpoint blockade therapy also induces changes in PD-1 − CD8 + TILs, which can contribute to the therapeutic ...T cells (Treg), as CTLA-4 is constitutively ...
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Immune checkpoints on innate lymphoid cells
... functions in ILC-2s, similar to what has previously demonstrated in CD8 + T cells (Duraiswamy et al., 2011). Additional data came from exper- iments performed in mice infected with Nippostrongylus ...
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Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-defensin 14 Expression in Pancreatic Endocrine Cells Preventing Autoimmune Diabetes
... IL-22 promotes pancreatic expression of mBD14 We next sought to determine the pathway governing pancreatic expression of mBD14 and why this pathway was defective in NOD mice. In the gut, but also in other tissues ...
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![CD8[superscript +] T-cell Responses Rapidly Select for Antigen-Negative Tumor Cells in the Prostate](https://data07.123doks.com/thumbv2/123doknet/000/481/481436/cover.webp)
CD8[superscript +] T-cell Responses Rapidly Select for Antigen-Negative Tumor Cells in the Prostate
... + cells continue to grow within the tumor ...tumor cells in TRP-SIY mice prior to T cell treatment further suggests that the outgrowth of Tag + SIY - tumor cells compromised the efficacy of 2C T cell ...
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Tissue Infiltrating LTi—Like Group 3 Innate Lymphoid Cells and T Follicular Helper Cells in Graves' and Hashimoto's Thyroiditis
... B cells in HT and GD group 1 tissues while those were absent in control and Group 2 GD ...+ cells or the presence of GCs, we observed that GD Group 2 patients who did not develop local thyroid TLS and GCs ...
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Immunomodulatory properties of human MuStem cells: assessing their impact on adaptive and innate immunity
... cultured cells to explore whether FGF-4 is capable to interact with the adenoviral vector and endogenous ...the cells, which were treated 24 hours later by FGF-4 ...3T3 cells (growth ...endothelial ...
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Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection
... fic CD8+ T cells from chronic ...fic CD8+ T cells from chronically evolving ...fic CD8+ T cells from T2/late chronic and T2/late self-limited HCV infection and in healthy controls ...
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