IL-1 receptor antagonist (IL-1Ra)
Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism
... (21,24). Interestingly, it was recently demonstrated in the carrageenan-induced pleu- risy model that rosiglitazone reduced pleural exudate volume and mononuclear cell infiltration (22), as was previously shown for ...
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The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.: PPARalpha controls the expression of the sIL-1ra in liver
... Interleukin 1 Receptor antagonist is a direct target gene of PPAR with a functional PPRE in its promoter, suggesting that PPAR may also govern inflammation by direct up-regulation of target ...
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Production of interleukin-1 receptor antagonist by human articular chondrocytes.
... chondrocytes mainly produce the secreted isoform. Using specific primers, we confirmed that articular chondrocytes produce predominantly sIL-1Ra mRNA. A similar stimulation of sIL-1Ra production by IL-1β, ...
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Long-term effectiveness and safety of interleukin-1 receptor antagonist (anakinra) in Schnitzler's syndrome: A French multicenter study.
... U SC R IPT of prednisone). However, the outcome was fatal in two cases and it cannot be stated whether the same would have occurred in the absence of blocking IL-1Ra. On the other hand, pursuing high dose ...
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PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons.: IGF-1 transactivates PACAP type I receptors
... MALDI-TOF mass spectrometry and protein identification Protein spots were excised and digested in-gel using trypsin (Gold, Promega), as previously described (Delcourt et al., 2005). Digested samples were dehydrated in a ...
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Targeting the vascular tone of microarterioles with an endothelin-1 (ET-1) antagonist selectively modulates tumor blood flow and promotes response to treatment
... INTRODUCTION 1. In tumors, ET-1 is known as a potent autocrine and paracrine growth-factor produced by tumor cells. 2. In the vascular field, ET-1 is also known as a potent vasoconstrictor acting ...
1
Structure prediction of GPCRs using piecewise homologs and application to the human CCR5 chemokine receptor: validation through agonist and antagonist docking
... CCR5 receptor using multiple homology ...CXCR4 receptor of known crystal ...the receptor cavity of chemokine receptors at molecular and atomic ...
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High Content Screening Using New U2OS Reporter Cell Models Identifies Harmol Hydrochloride as a Selective and Competitive Antagonist of the Androgen Receptor
... pure antagonist enzalutamide and could also compete with ligand binding at a concentration than is only ...AR antagonist [26], it is possible that other indirect mechanisms may be ...
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JAB1 Interacts with Both the Progesterone Receptor and SRC-1
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Ciproxifan, a Histamine H 3 -Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of Haloperidol in the Rat
... lin mRNA expression elicited by haloperidol in the rat striatum. Top, The proenkephalin mRNAs were visualized by in situ hybridization on films 3 hr after intraperitoneal administration of saline solution (CONTROL), ...
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Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.
... although our data do not allow to formally exclude the possibility of a defect in tissue repair mechanisms in PAR-1-deficient mice. Our results confirm and extend the observations of Fiorucci et al. These authors ...
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Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
... together with the indicated concentration of MSX-3 or vehicle. Slices were washed and fixed in 4% PFA. Aβ dense-core plaques were stained with 0.001% thiazine red (Sigma Aldrich) in PBS. Five corresponding regions of ...
14
Current concepts regarding the HTLV-1 receptor complex.
... Targeting DC and interfering with NRP-1 signalling might have several other consequences on viral infec- tion. HTLV-1 infection results in a depletion of myDC as well as pDC and an impairment of their ...
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Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling.
... translated RyR1 fragment (~ 30 fmoles) in 1 ml of binding buffer (50 mM Tris, pH 7.4, 100 mM NaCl, 1 mM MgCl 2 , 0.1 mM DTT, and 0.1 % CHAPS) at 4°C for 15 hours with agitation. Beads were washed ...
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L'impact des perturbations du cytosquelette sur l'expression et la fonction de la low-density lipoprotein receptor-related protein 1 (LRP-1)
... T he cytoskeleton ' s role is integral to alm ost every cellul ar function: it i s the structure that gives cells their shape , mediates the controll ed movement o[r] ...
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en fr CSF-1 receptor nuclear functions in human monocytes Fonctions nucléaires du récepteur de CSF-1 dans les monocytes humains
... 86 CSF-1R ChIP-Seq was performed in macrophages generated by exposure of monocytes from 3 healthy donors to CSF-1 during 72h (same donors as in figure 15). Peak calling identified a mean number of 145,382 peaks, ...
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Structure-Function Similarities between a Plant Receptor-like Kinase and the Human Interleukin-1 Receptor-associated Kinase-4
... Do¨rte Klaus-Heisen ‡1 , Alessandra Nurisso §1 , Anna Pietraszewska-Bogiel ¶1 , Malick Mbengue ‡2 , Sylvie Camut ‡ , Ton Timmers ‡ , Carole Pichereaux 储 , Michel Rossignol 储 , Theodorus W. J. Gadella ...
11
en fr Sigma 1 Receptor : Role in Hepatocyte Proliferation and Steatosis Le récepteur Sigma 1 : implication dans la prolifération et la stéatose des hépatocytes
... nuclear receptor of estrogens and not the GPR30 membrane receptor since the addition of 17βestradiol to HepG2 cells, which show endogenous expression of GPR30, but not ER (Ikeda et ...
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Dipeptidylpeptidase-4 (DPP-4) inhibitors are favourable to glucagon-like peptide-1 (GLP-1) receptor agonists: yes.
... gastrointestinal adverse events than sitagliptin (nausea: 24 % versus 10%; vomiting: 11 versus 2%) [19]. An extension of this study showed that patients who switched to once-weekly exenatide from daily sitagliptin had ...
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Sphingosine 1-Phosphate Receptor 1 Modulates CNTF-Induced Axonal Growth and Neuroprotection in the Mouse Visual System
... Accepted 1 August 2017; Published 6 November 2017 Academic Editor: Preston ...sphingosine 1-phosphate receptor 1 (S1PR1) to the neuroprotective and regenerative e ffects of ...
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