human hepatocellular carcinoma
Screening of natural stilbene oligomers from Vitis vinifera for anticancer activity on human hepatocellular carcinoma cells
... 4. Discussion The results presented herein show for the first time that several natural oligomeric products of resveratrol, in particular tetramers, are cytotoxic to human hepatocellular carcinoma ...
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Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma
... of human hepatocellular carcinoma cells, is described ...the human hepatocellular carcinoma cell line, HepG2, in division, but not into growing, healthy, human endothelial ...
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Local Anesthetics Inhibit the Growth of Human Hepatocellular Carcinoma Cells
... HuH7, HepaRG progenitors, and differentiated HepaRG cell lines were cultured in the presence of indicated concentrations of lidocaine (A) and ropivacaine (B) for 48 h and cell viabi[r] ...
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“Fibrous nests” in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome
... DISCUSSION We found that tumors containing fibrous nests were less differentiated and expressed Wnt pathway components and target genes as well as stem/progenitor cell markers. Tissue microarray-based ...
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Insulin receptor isoform A favors tumor progression in human hepatocellular carcinoma by increasing stem/progenitor cell features
... The insulin receptor (IR) tyrosine kinase (TK) exists in two isoforms, IR-A and IR-B, due to alternative splicing of exon 11 encoding 12 amino acids located at the carboxy-terminal domain of extracellular subunits. IR-B ...
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Prokineticin 2/Bv8 is expressed in Kupffer cells in liver and is down regulated in human hepatocellular carcinoma.
... Justin Monnier, Claire Piquet-Pellorce, Jean-Jacques Feige, Orlando Musso, Bruno Clément, Bruno Turlin, Nathalie Théret, Michel Samson.. To cite this version:[r] ...
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Specificities of Human Hepatocellular Carcinoma Developed on Non-Alcoholic Fatty Liver Disease in Absence of Cirrhosis Revealed by Tissue Extracts 1H-NMR Spectroscopy
... necessary to identify metabolic specificities of HCC developed on NAFLD in absence of cirrhosis. The main result of this study is that HCC associated with non-cirrhotic NAFLD specifically exhibited a high level of Gln. ...
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In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence.: Reptin silencing blocks liver cancer progression
... Figure 5. Mechanisms of anti-tumor effects in vivo A, The R2 and GL2 cell lines were injected subcutaneously into NOG mice (n = 5 in each group). When tumor volume reached 250 mm3, Dox (2mg/mL), or sucrose, was ...
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Comparative Analysis of TGF-β/Smad Signaling Dependent Cytostasis in Human Hepatocellular Carcinoma Cell Lines
... of human hepatocarcinogenesis by providing a robust rationale for the use of relevant HCC cell lines to model specific aspects of HCC onset and ...of human HCC cell ...
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Low Levels of Microsatellite Instability at Simple Repeated Sequences Commonly Occur in Human Hepatocellular Carcinoma
... Abstract. Background/Aim: The aim of this study was to assess the incidence of MSI in a large series of human hepatocellular carcinomas (HCC) with various etiologies. Materials and Methods: The MSI status ...
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Safety and efficacy of intra-arterial hepatic chemotherapy with doxorubicin-loaded nanoparticles in hepatocellular carcinoma
... 14. Park JG, Lee SK, Hong IG, et al. MDR1 gene expression: its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines. J Natl Cancer Inst 1994;86:700–5. 15. Zaman GJ, ...
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[Fundamental and translational research on hepatocellular carcinoma in 2008: forces and priorities]
... and hepatocellular carcinoma development in patients with alcoholinduced cirrhosis Cancer Res 2006; 66: 284452 5 Thorgeirsson SS Grisham JW Molecular pathogenesis of human ...
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Phase 1b/2 trial of tepotinib in sorafenibpretreated advanced hepatocellular carcinoma with MET overexpression
... In HCC, tepotinib has demonstrated preclinical activity in patient-derived primary liver cancer explants, in which sensitivity to the drug was associated with MET overexpression. 26 These data, together with the ...
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Role of methalothionein in irradiated human rectal carcinoma.
... DISCUSSION The lack of reliable criteria to predict the outcome after preoperative radiotherapy for individual patients with advanced rectal carcinoma is a major problem. The precise mechanism of radioresistance ...
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Transforming Growth Factor-β and Axl Induce CXCL5 and Neutrophil Recruitment in Hepatocellular Carcinoma
... Globally, liver cancer is the fifth most frequently diagnosed cancer and the second most frequent cause of cancer-related deaths (1). Hepatocellular carcinoma (HCC) accounts for 70% to 85% of the total ...
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Ruptured hepatocellular carcinoma following transcatheter arterial chemoembolization.
... Hepatocellular carcinoma (HCC) is one of the most common cancers in the ...(1). Hepatocellular carcinoma is of poor prognosis: the five-year sur- vival rate is less than 5 percent ...
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Hyperinsulinemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma
... exacerbated hepatocellular insulin resistance, insulin clearance from the circulation that occurs mainly via receptor-mediated endocytosis, is reduced in patients with ...
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Discrimination of cirrhotic nodules, dysplastic lesions and hepatocellular carcinoma by their vibrational signature
... Characterization of quantifiable spectral markers for diagnosis of benign, dysplastic and malignant lesions The possibility of grading hepatocellular nodules in cir- rhotic livers using laboratory-based infrared ...
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The heterogeneity of plasma miRNA profiles in hepatocellular carcinoma patients and the exploration of diagnostic circulating miRNAs for hepatocellular carcinoma
... Materials and methods Patients, plasma preparation, and tissue preparation A study population of ten HCC patients was enrolled at the Sun Yat-sen University Cancer Center (Guangzhou, China). The diagnosis of HCC was ...
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Nomogram for individualized prediction of hepatocellular carcinoma occurrence in hepatitis C virus cirrhosis (ANRS CO12 CirVir)
... Nomogram for individualized prediction of hepatocellular carcinoma occurrence in HCV-cirrhosis (ANRS CO12 CirVir) Short title: Predictive score for HCC in HCV-cirrhosis. Nathalie Ganne-Carrié 1, 2, 3 , MD ...
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