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HUMAN GENOME

Replication landscape of the human genome

Replication landscape of the human genome

... the human genome (version 73) were retrieved from the Ensembl Genome Brower ...the genome was segmented into regions according to replication timing, assigned as S1, S2, S3 or ...

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Genome-wide binding map of the HIV-1 Tat protein to the human genome

Genome-wide binding map of the HIV-1 Tat protein to the human genome

... the human genome. Here, we report the genome-wide binding map of Tat to the human genome in Jurkat T cells using chromatin immunoprecipitation combined with next-generation ...host ...

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Structural basis for HIV-1 DNA integration in the human genome

Structural basis for HIV-1 DNA integration in the human genome

... the human immunodeficiency virus type 1 (HIV-1) cDNA into the human genome is catalyzed by the viral integrase protein that requires the lens epithelium- derived growth factor (LEDGF), a cellular ...

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Structural variations of the human genome and transcriptome induced by LINE-1 retrotransposons

Structural variations of the human genome and transcriptome induced by LINE-1 retrotransposons

... the human genome (hg19), the repeat-masked human genome (hg19 RM) and in polymorphic L1 insertion datasets (dbRIP, Solyom 2012 and Lee ...(D) Human L1s preferentially insert into target ...

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Closing gaps in the human genome using sequencing by synthesis

Closing gaps in the human genome using sequencing by synthesis

... The human genome still contains 127 class III gaps, 21 of which overlap RefSeq gene annotations [16]. Most of these will have been abandoned as refractory to current techniques because of the absence of ...

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Quantification of GC-biased gene conversion in the human genome

Quantification of GC-biased gene conversion in the human genome

... to human polymorphism data from the 1000 Genomes Project, we show that the strength of gBGC does not differ between hypermutable CpG sites and non-CpG sites, suggesting that in humans gBGC is not caused by the ...

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Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome.

Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome.

... complete genome duplication are ...of human genome replication kinetics using a combination of DNA combing, which reveals local patterns of origin firing and replication fork progression on single ...

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Transcription-coupled TA and GC strand asymmetries in the human genome

Transcription-coupled TA and GC strand asymmetries in the human genome

... S GC = 7.8% ( Section 2 , Fig. 4 ). This value of S TA was similar to our observations. However, S GC was much larger than that observed here. Several reasons might explain this discrepancy. First, the excess of GC bias ...

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Investigating the function of histone H2A.Z in the human genome and mechanisms of chromatin incorporation

Investigating the function of histone H2A.Z in the human genome and mechanisms of chromatin incorporation

... the human genome is restricted to very specific loci such as gene transcription start sites (TSS), enhancers, and insulator sites (Gevry et ...in human cells and in yeast, that ...

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Characterizing and predicting enhancers in the human genome

Characterizing and predicting enhancers in the human genome

... Chromatin state data has been collected for the human genome across approximately 90 different cell types.. However, regulatory processes change across different cell types and[r] ...

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Defining functional DNA elements in the human genome

Defining functional DNA elements in the human genome

... approach quantifies selective constraint, and the biochemical approach measures evidence of molecular activity. All three approaches can be highly informative of the biological relevance of a genomic segment and groups ...

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Characterizing variation at short tandem repeats and their role in human genome regulation

Characterizing variation at short tandem repeats and their role in human genome regulation

... Short tandem repeats (STRs), also known as microsatellites, are a class of genetic variations with repetitive elements of 2 to 6 nucleotides that consists of approx[r] ...

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Bioinformatics approach for the identification of fragile regions on the human genome

Bioinformatics approach for the identification of fragile regions on the human genome

... Studies on the genome synteny have shown that conserved regions are not only significantly enriched in putative regulatory regions (Mongin et al. To infer the evol[r] ...

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Analysis of a Proposed First Generation Physical Map of the Human Genome

Analysis of a Proposed First Generation Physical Map of the Human Genome

... By contrast, STS pairs at < 5 cM show significantly higher connectivity for path length < 3 in the real data than in the randomized data, with the difference attributable [r] ...

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Multi-scale structural community organisation of the human genome

Multi-scale structural community organisation of the human genome

... IMR90 it increases from 40% for TADs ∼ 1 Mb up to 70% for TADs ≥ 2 Mb and in H1 ES from 70% for TADs ∼ 1 Mb up to 85% for TADs of ∼ 2 Mb (Fig. 5b). Compari- son of TAD borders to interval-community borders shows good ...

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Searching for novel peptide hormones in the human genome

Searching for novel peptide hormones in the human genome

... contract human LES (Cohen and Lipshutz 1971), vasoactive intestinal peptide (VIP) which has a relaxation effect on human, cat, and baboon LES (Biancani et ...

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Mobile Elements in the Human Genome: Implications for Disease

Mobile Elements in the Human Genome: Implications for Disease

... Exon skipping: splicing modification following the insertion of a transposable element that 541. result in the skipping of one or more exon during mRNA maturation[r] ...

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Design of a genetics database for gene clips and the Human Genome database

Design of a genetics database for gene clips and the Human Genome database

... The DistributedQuery object contains three String versions of the query: the original federated query, the federated query mapped with its database paths (DBPath), and the [r] ...

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Genome-wide studies highlight indirect links between human replication origins and gene regulation.

Genome-wide studies highlight indirect links between human replication origins and gene regulation.

... a genome-wide view of replication initiation was still ...a genome-wide mapping of replication origins based on hybridization of SNS to DNA microarrays, covering 30 Mb of the human ...Drosophila ...

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Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture

Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture

... for Genome Architecture thanks Janice, Robert, and Cary McNair for ...National Human Genome Research Institute (NHGRI) Center for Excellence for Genomic Sciences Grant HG006193, an NVIDIA Research ...

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