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Human cytotoxic T lymphocyte

P16-23. Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance

P16-23. Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance

... Address: 1 University of Mainz, Mainz, Germany, 2 INSERM, Unité 580, Université Paris-Descartes, Paris, France, 3 University of Copenhagen, Copenhagen, Denmark, 4 Rigshospitalet, The National University Hospital, ...

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Polyoxidonium® Activates Cytotoxic Lymphocyte Responses Through Dendritic Cell Maturation: Clinical Effects in Breast Cancer

Polyoxidonium® Activates Cytotoxic Lymphocyte Responses Through Dendritic Cell Maturation: Clinical Effects in Breast Cancer

... and Human Epidermal Growth Factor 2 (HER2), and had a high proliferative index as measured by a high proliferation ratio based on Ki-67 staining (Figure ...

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Lutte d’influence membranaire pour inhiber ou activer le lymphocyte

Lutte d’influence membranaire pour inhiber ou activer le lymphocyte

... from human activated NK lymphocytes and inhibits cell-mediated ...within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic ...

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Cytotoxic T-lymphocyte-associated protein 4-Ig effectively controls immune activation and inflammatory disease in a novel murine model of leaky severe combined immunodeficiency

Cytotoxic T-lymphocyte-associated protein 4-Ig effectively controls immune activation and inflammatory disease in a novel murine model of leaky severe combined immunodeficiency

... CTLA4-Ig meets all of the intervention criteria listed above. First, as a potent suppressive molecule used by Treg cells for immune suppression, 22 CTLA4-Ig can be substitutive for Treg cells. Second, CTLA4-Ig is highly ...

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en fr Influence of hypoxia on tumour cell susceptibility to cytotoxic T lymphocyte mediated lysis Influence de l’hypoxie sur la susceptibilité des cellules tumorales à la lyse induite par les lymphocytes T cytotoxiques

... 48 IV. ANTI-TUMOR IMMUNE RESPONSE The major feature of the immune system is its ability to recognize “self” from “foreign” and to destroy the latter, potentially dangerous for host homeostasis. In this context, the ...

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Melanoma Cells Treated with GGTI and IFN-gamma Allow Murine Vaccination and Enhance Cytotoxic Response against Human Melanoma Cells.

Melanoma Cells Treated with GGTI and IFN-gamma Allow Murine Vaccination and Enhance Cytotoxic Response against Human Melanoma Cells.

... The specific cytotoxicity observed after co-cultivating PBMC with LB1319-MEL cells pretreated with the combination of hIFN- c and GGTI-298, suggests that these melanoma cells develop the ability to induce a specific ...

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en fr Dissecting early mechanism of melanoma cell resistance to cytotoxic T lymphocyte attack Etude du mécanisme précoce de la résistance des cellules du mélanome à l'attaque des lymphocytes T cytotoxique

... 88 II- Aim of the study Background: Several lines of evidence indicate that an endogenous immune response against cancer develops in some patients. Tumor-specific CTL expand at relatively high frequency in cancer ...

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Dissecting early mechanism of melanoma cell resistance to cytotoxic T lymphocyte attack

Dissecting early mechanism of melanoma cell resistance to cytotoxic T lymphocyte attack

... 88 II- Aim of the study Background: Several lines of evidence indicate that an endogenous immune response against cancer develops in some patients. Tumor-specific CTL expand at relatively high frequency in cancer ...

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Sequential adjustment of cytotoxic T lymphocyte densities improves efficacy in controlling tumor growth

Sequential adjustment of cytotoxic T lymphocyte densities improves efficacy in controlling tumor growth

... plex to extrapolate to clinical settings. To overcome such a technical bottleneck, we designed an agent-based model, calibrated on experimental measurements, which accurately reproduces human CTL/tumor cell ...

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Sequential adjustment of cytotoxic T lymphocyte densities improves efficacy in controlling tumor growth

Sequential adjustment of cytotoxic T lymphocyte densities improves efficacy in controlling tumor growth

... of human CTL efficacy against cancer ...of human CTL per capita killing ...of human CTL/tumor cell interaction is indeed crucial to define how efficient individual CTL are when facing cancer cells for a ...

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Recombinaisons suicides du locus IgH - Quand le lymphocyte B dépose les armes !

Recombinaisons suicides du locus IgH - Quand le lymphocyte B dépose les armes !

... Les deux événements, SHM comme CSR, nécessitent la transcrip- tion des régions cibles sous le contrôle d’activateurs situés à l’extrémité 3’ du locus IgH, dans la région 3’ régulatric[r] ...

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Biophysical mechanisms of lymphocyte adhesion to activated vascular endothelium

Biophysical mechanisms of lymphocyte adhesion to activated vascular endothelium

... The expression studies revealed that fluid extracted from the tumor interstitium upregulates specific CAMs on endothelial cells in vitro, which promotes lymphocyte bin[r] ...

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The endocrine milieu and CD4 T-lymphocyte polarization during pregnancy

The endocrine milieu and CD4 T-lymphocyte polarization during pregnancy

... estradiol, human chorionic gonadotropin, luteinizing hormone, regulatoryT cells,T helper 17 cells, pregnancy INTRODUCTION Pregnancy constitutes an immunological paradox since it implies that a fetus ...

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Highly Cytotoxic Copper(II) Terpyridine Complexes as Anticancer Drug Candidates

Highly Cytotoxic Copper(II) Terpyridine Complexes as Anticancer Drug Candidates

... ABSTRACT Cancer is one of the deadliest diseases worldwide. Chemotherapy remains one of the frequently applied treatment modalities in the clinics. However, as the currently applied agents are associated with severe ...

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Autophagy and CD4+ T lymphocyte destruction by HIV-1.

Autophagy and CD4+ T lymphocyte destruction by HIV-1.

... 9. Debatin KM, Fahrig-Faissner A, Enenkel-Stoodt S, Kreuz W, Benner A, Krammer PH. High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children. Blood 1994; 83:3101-3. 10. ...

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The role of SHIP1 in T-lymphocyte life and death

The role of SHIP1 in T-lymphocyte life and death

... Tel: + 32 4 366 24 26, Fax: + 32 4 366 99 33 Key Words: SHIP-1, T lymphocyte, PI3K, NF-κB, apoptosis, proliferation. ABBREVIATIONS PI3K: phosphoinositide 3-kinase; ITIM: immuno-receptor tyrosine inhibition motif; ...

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New low-cytotoxic P-containing nitrones targeting mitochondria

New low-cytotoxic P-containing nitrones targeting mitochondria

... Figure 1: Structure of new low-cytotoxic nitrones targeting mitochondria New mito-PPNs were good EPR probes for biologically-relevant carbon- and oxygen-derived free radicals, efficiently inhibited superoxide in ...

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[Autophagy and CD4 T lymphocyte destruction by HIV-1]

[Autophagy and CD4 T lymphocyte destruction by HIV-1]

... T lymphocyte destruction by HIV-1 REMERCIEMENTS Ce travail a été soutenu par le Centre National de la Recherche Scientifique (CNRS), l’Université Montpellier I (UMI), Sidaction et l’Agence Nationale de Recherche ...

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Actin nucleation at the centrosome controls lymphocyte polarity.

Actin nucleation at the centrosome controls lymphocyte polarity.

... both cytotoxic lymphocytes and natural killer cells 11 , of cytokine-loaded vesicles in helper T cells 12,13 and of hydrolase-containing lysosomes in B cells 5,14 ...

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Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells

Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells

... S1 Methods. Expression of stemness, pluripotency and differentiation markers in prolifer- ating and quiescent GSCs. The expression levels (mRNA) of 90 genes enclosing stemness, pluripotency and differentiation markers ...

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