human CD4+ T-cells
Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells
... of CD4 + CD25 hi FoxP3 + natural regulatory T cells, and suggest that HLA-DR may have a functional role in these cells ...in human CD4 + T cells has not been ...
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SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue
... of human lymphoid tissues ex ...of CD4+ T cell depletion in the tissue blocks (left) and cells that migrated in the gel foams (right) at the end of culture at 15 days ...HEK293T cells were ...
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Interleukin-17-producing decidual CD4+ T cells are not deleterious for human pregnancy when they also produce interleukin-4
... the human effector CD4+ T helper cells have been classified as T helper (Th)1, (Th)2 and, more recently, as (Th17) cells [ 3 , 4 ...Indeed, CD4+ Th1 cells, which produce ...
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P17-04. Targeting HIV peptides to human dendritic cells via CD40 elicits expansion of multi-epitope polyfunctional CD4+ and CD8+ T cells in HIV patients
... internalizing human DC receptors and engineered them fused via the heavy chain C-terminus to a string of five 19- to 32-amino-acid long sequences from HIV-1 Gag, Nef and Pol proteins ...conserved CD4+ and ...
2
en fr Development of cellular immunotherapeutic strategies based on the activation of human CD4+ TL by artificial antigen presenting cells Développement de stratégies d'immunothérapies cellulaires basées sur l'activation de lymphocytes T CD4+ humains à l'aide de cellules présentatrices d'antigène artificielles.
... ABSTRACT CD4 T cell help is essential to promote robust cytotoxic T cell responses and could be harnessed to improve outcomes of cancer ...induce CD4+ T cell responses, we have previously developed ...
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IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity
... naive CD4 T-cell counts, indicating that the loss of cell replenishment due to thymic invo- lution is complemented by peripheral dilution due to cell prolif- eration ( 4 , 6 – 8 ...the human naive ...
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Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy
... incubation with increasing concentration of 3a-G1-Julo, we observed an increase in the mean fluorescence inten- sity of the cells, indicating a progressive labelling of the cells (Fig. 5a). However, the ...
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B7-H5 costimulates human T cells via CD28H
... co-stimulates human T cells through CD28H (a, b) Purified human CD4+ T cells were negatively selected and stimulated with OKT3 together with coated B7-H5, the control protein FLAG, and ...
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P04-27. Monoclonal neutralizing antibodies inhibit HIV-1 transfer from immature dendritic cells to human primary CD4 T-lymphocytes
... p24 released in the supernatant of the co-culture was only reduced in presence of antibodies. Conclusion Here we clearly demonstrated that neutralizing antibodies are efficient inhibitors of HIV transfer to CD4 T ...
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CD40L confers helper functions to human intra-melanoma class-I-restricted CD4 + CD8 + double positive T cells
... Although CD40L expression is mainly associated to helper CD4C T cells, early in vitro studies described that a subset of CD8C T cells can also induce, upon activation, the expression of [r] ...
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Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.
... inhibit human Th17 cell differentiation and function and induce a regulatory T cell phenotype ...Treg cells in vitro during the differentiation process or on fully differentiated Th1 and Th17 cells ...
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HIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomised phase 2 trial
... and CD4 + T-cell ...mediated CD4 + T-cell depletion, we immunised simian HIV (SHIV)- infected macaques with a 3S-based ...of CD4 + T cells from death and decreased immune activation and in ...
10
CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells
... the cells were resuspended in R10 and counted by Trypan Blue (Millipore, Billerica, MA) ...The cells were centrifuged at 1500 rpm for 5 minutes and plated at a density of 1 million cells per well in ...
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A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4+ and CD8+ T Cells
... the human population produc- ing significant morbidity, mainly because of the generation of genital ulcers and neonatal ...dendritic cells, professional antigen presenting cells that process viral ...
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Function of the immunoregulatory CD4-CD8- T cells in the context of autoimmune diabetes
... to human DN T cell studies. Although human DN T cells have been investigated by other groups 169, 238 , they have not been investigated in the context of autoimmune ...whether human DN T ...
241
Human Lymphoid Stromal Cells Contribute to Polarization of Follicular T Cells Into IL-4 Secreting Cells
... However, supervised stringent analysis identified only few differentially expressed genes between tonsil and FL LN R5- PD1 d i m : 47 upregulated and 38 downregulated genes ( Supplemental Table S4 ). Using Gene Set ...
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Human mucosal associated invariant T cells detect bacterially infected cells.
... T cells are restricted by ...T cells in response to DCs (25,000/well) treated as ...detection, cells were incubated with antibodies specific for ...represents CD4 + HLA-II–restricted clone ...
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Characterizing antigen-specific CD4⁺ T cells using HLA-DR oligomers
... c HLA-A2, rt peptide from HIV Figure I.3. Structures of MHC-peptide complexes. Peptide-binding MHCs are divided into class I and class II proteins. Structures determined by x-ray crystallography of examples from each ...
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Regulation of B cell responses by distinct populations of CD4 T cells
... Tfr cells [61] ...Treg cells, Tfr cells could also arise from Foxp3 neg precursors if the adjuvant used was one that sup- ports T cell plasticity [61] ...T cells showing that this phe- nomenon ...
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Coxsackievirus B4 infection of human fetal thymus cells
... incubation, cells were rinsed, pelleted, and resuspended in 100 l of phosphate-buffered saline (PBS)–2% FCS for FACS ...markers, cells were rinsed and ...of human gamma globulin/ ml, and 0.1% Triton ...
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