• Aucun résultat trouvé

Histone deacetylase

Effect Of Inhibitors Of Histone Deacetylase On The Induction Of Cell Differentiation In Murine And Human Erythroleukemia Cell Lines

Effect Of Inhibitors Of Histone Deacetylase On The Induction Of Cell Differentiation In Murine And Human Erythroleukemia Cell Lines

... Franck Dequiedt c,d , Eric Verdin d , Clarissa Gerha¨user b and Manfred Jung a Histone deacetylase (HDAC) inhibitors are a novel class of promising anti-cancer agents. Little information is available on the ...

9

mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity.

mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity.

... II histone deacetylase, HDAC4, can interact with two different members of MEF2 family, MEF2A (12) and MEF2C ...II deacetylase, is also able to interact specifically with the MEF2A transcription ...

16

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

... enhancer; histone deacetylases; epigenetic; chromatin; acetylation; CREB ...by histone deacetylase (HDAC) inhibitors depends on CREB and its interaction with the coactivator CBP (CREB- binding ...

35

Prominent action of butyrate over beta-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

Prominent action of butyrate over beta-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

... be histone deacetylase (HDAC) inhibitors, and their administration has been associated to an improved metabolic profile and better cellular oxidative status, with butyrate inducing PGC1α and fatty acid ...

15

Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways.

Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways.

... murine histone deacetylase 6 (mHDAC6), a member of the class II HDACs, from mouse testis cytosolic extracts allowed the identification of two associated ...

24

Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells

Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells

... Combination of azacytidin, vorinostat, rapamycin and IL-2 enhances FOXP3 expression in expanding nTreg cells Since the addition of rapamycin to IL-2 is insufficient to maintain high expression of FOXP3 in nTreg, we ...

13

Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

... Aberrant deacetylase activity can promote or suppress tumorigenesis and cancer metastasis in different types of human cancers, including breast ...class-III histone deacetylase (HDAC) that ...

15

Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors.

Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors.

... Hartl M, Nist A, Khan MI, Valovka T, Bister K (2009) Inhibition of Myc-induced cell transformation by brain acid-soluble protein 1 (BASP1). Proc Natl Acad Sci U S A 106(14): 5604-9 Heller G, Schmidt WM, Ziegler B, Holzer ...

39

Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury.

Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury.

... genes. Histone deacetylase inhibitor (HDACi) treatment results in an accumulation of acety- lated proteins, which has been shown to either increase gene expression by reducing chromatin compaction or reduce ...

17

Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication

Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication

... In infected cells, IN functions in the context of the pre- integration complex (PIC), a large nucleoprotein complex formed in the cytoplasm with components derived from the core of the infecting virion (viral cDNA, ...

17

en
                                                                    fr

en fr Ubiquitin dependant functions of Histone deacetylase HDAC6 FONCTIONS UBIQUITINE-DEPENDANTES DE LA DEACETYLASE HDAC6

... (2005) Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase in[r] ...

211

Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines

Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines

... ○ Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles, 1050 Brussels, Belgium * S Supporting Information ABSTRACT: A new series of ...

20

Histone deacetylase inhibitors and genomic instability.

Histone deacetylase inhibitors and genomic instability.

... Abstract: Histone deacetylase inhibitors (HDACIs) are a promising new class of anticancer drugs. However, their mechanism of action has not been fully elucidated. Most studies have investigated the effect ...

33

en
                                                                    fr

en fr Epigenetic regulation of polymerase III RNA transcription machinery by histone deacetylase SIRT1 Régulation épigénétique de la machinerie de transcription de l'ARN polymérase III par l'histone désacétylase SIRT1

... SIRT1 dans les complexes répressifs Polycomb Les modifications des lysines des histones sont des éléments importants de la machinerie épigénétique régulant la structure de la chromatine et l’expression génique. La ...

180

PKB mediates Insulin-Like Growth Factor 1-induced phosphorylation and nuclear export of Histone Deacetylase 5 via NADPH Oxidase 4 activation in vascular smooth muscle cells

PKB mediates Insulin-Like Growth Factor 1-induced phosphorylation and nuclear export of Histone Deacetylase 5 via NADPH Oxidase 4 activation in vascular smooth muscle cells

... the histone proteins that make up chromatin is correlated with the transcriptional status of a given gene (119), information regarding HDAC structure has only become available more ...

118

A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.

A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.

... and histone H3 known as the nucleosomal response ...of histone H3 at serine 10 was previously shown to be associated with transcriptional activation of a variety of mammalian genes ...of histone H3, ...

20

Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity

Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity

... leads. Histone deacetylases (HDACs) play key roles in diverse intracellular processes and epigenetic regulation through the modification of histone and nonhistone proteins to repress ...

9

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1

Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1

... specifically histone deacetylases (HDACs) and bromodomains, have emerged as novel promising targets for anticancer ...vs histone acetylation), and by assessing their effects on various cancer cell ...

38

Antidepressant Actions of Histone Deacetylase Inhibitors

Antidepressant Actions of Histone Deacetylase Inhibitors

... Discussion Histone acetylation is a promising target for novel treatments of psychiatric illness because of its control over patterns of gene transcription that ultimately establish and stabilize cognitive and ...

11

Cytoplasmic I kappa B alpha increases NF-kappa B-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3

Cytoplasmic I kappa B alpha increases NF-kappa B-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3

... I ␬B␣ is an inhibitory molecule that sequesters NF-␬B dimers in the cytoplasm of unstimulated cells. Upon stimulation, NF- ␬B moves to the nucleus and induces the expression of a variety of genes including I ␬B␣. This ...

8

Show all 169 documents...

Sujets connexes