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Peer Influence on Aggression at School : How Vulnerable Are Higher Risk Adolescents?

Peer Influence on Aggression at School : How Vulnerable Are Higher Risk Adolescents?

3 Antisocial behavior among adolescents is characterized by recurrent violations of socially prescribed norms in public settings, at home, or in school environments (Simcha- Fagan, Langner, Gersten, & Eisenberg, 1975). This behavior includes “physical or verbal abuse of a person, damage to or theft of property, or victimless clandestine juvenile behaviors such as truancy and drug or alcohol use” (Loeber, 1985). This definition corresponds with the behavioral descriptions of conduct disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; American Psychiatric Association, 2013), which refer to aggression, destruction of property, deceitfulness or theft, and serious violations of rules. Although not all categories of antisocial behavior need to be present in conduct disorder at the same time, aggression and delinquency often co-occur (e.g., r = .616 in a study by Barnow, Lucht, & Freyberger, 2005). The negative consequences of antisocial behavior affect more than just the social environment—they also affect the youths in question. For example, youth who exhibit pronounced antisocial behavior are more likely to engage in criminal behavior in the future (e.g., Monahan, Steinberg, Cauffman, & Mulvey, 2009) and to experience school failure, psychological disorders, and social rejection (Quinn & Poirier, 2004). Adolescents who exhibit high levels of antisocial behavior can therefore be considered to be at increased risk for future negative outcomes and are in need of support. Hereafter, we refer to this group of adolescents as “higher-risk adolescents”.
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Are tall people at higher risk of low back pain surgery? A discussion on the results of a multipurpose cohort.

Are tall people at higher risk of low back pain surgery? A discussion on the results of a multipurpose cohort.

A mechanism possibly involved in the lumbar pathology is the role of lumbar disc height. Natarajan suggests that taller people have more potential for instability under external loading, because of higher discs exposed to much higher risk of failure 8 . An anthropometric study found that alterations of facet joints in patients with lumbar disc hernia were more

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Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d'etude des Tumeurs Endocrines (GTE) cohort study.

Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d'etude des Tumeurs Endocrines (GTE) cohort study.

abdominal imaging follow-up every 3 – 5 years. We would rec- ommend a reinforced follow-up program in patients who are genetically at risk because of a JunD-LOI mutation. In conclusion, this study demonstrates the existence of at-risk mutations within the codons involved in the interaction between MENIN and JunD. In this study, JunD-LOI was sig- nificantly associated with a higher risk of death. This reduced survival was secondary to pleiotropic MEN1 cancers, suggest- ing that the tumors are more aggressive. Specific recommen- dations for pancreatic surgery and follow-up might be pertinent in patients carrying a JunD-LOI mutation. The exist- ence of an heterogeneity across families in MEN1 syndrome is now established, suggesting the importance of genetic modify- ing factors in the variable expressivity of MEN1 syndrome.
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Azacitidine improves outcome in higher-risk MDS patients with chromosome 7 abnormalities: a retrospective comparison of GESMD and GFM registries

Azacitidine improves outcome in higher-risk MDS patients with chromosome 7 abnormalities: a retrospective comparison of GESMD and GFM registries

Information suggesting a particular efficacy of AZA in patients with Abn 7 was based on low patient numbers (Fenaux et al, 2009; Itzykson et al, 2011; Komrokji et al, 2013). Additionally, apart from the AZA-001 trial (Fenaux et al, 2009), there are no data comparing long-term outcomes after AZA and BSC. In the AZA-001 randomized clinical trial, AZA showed an OS benefit over conventional care in higher- risk MDS patients with Abn 7 (Fenaux et al, 2009), but only 30 patients in this category had received AZA. Several studies demonstrated that chemotherapy not a reliable option for patients with higher-risk MDS and AML with CK because of the lower complete response rates (46% as compared to 70% for those with no CK) and the poorer OS (median of 4 months as compared to 18 months for those with normal karyotype)
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Genetic and Functional Profiling of CD16-Dependent Natural Killer Activation Identifies Patients at Higher Risk of Cardiac Allograft Vasculopathy

Genetic and Functional Profiling of CD16-Dependent Natural Killer Activation Identifies Patients at Higher Risk of Cardiac Allograft Vasculopathy

14 early stratification of patients at risk is also a major challenge that favors the personalized indication of treatment. The potential contribution of genetic variation conditioning inflammatory processes resulting from CRP ligation to Fc-R has been evoked as a mechanism promoting vascular injury and predisposition to cardiovascular disease. Targeted anti- inflammatory therapies have been proposed as a novel approach to reduce cardiovascular risk 34 . Our study is the first establish a link between the genetic variation of the FCGR3A/ CD16 activating Fc-R and the predisposition for heart vasculopathy. Recent reports have identified the Fc-Receptor CD16 as a major checkpoint controlling inflammatory and vascular cytotoxicity resulting from immune alloreactivity. A recent report 21 illustrated the clinical potential of biopsy measurement of CD16 and NK cell transcripts to refine classification and diagnosis of antibody mediated heart transplant rejection. In this context, our study provides evidence that CD16 profiling identifies non-invasive biomarkers that reflect the intrinsic potential of a given recipient to mount deleterious cytotoxic immune responses towards heart vasculature. The strength of this study is to provide evidence that the FCGR3A-VV genetic variant encoding the CD16 receptor with high affinity for the Fc portion of antibodies is associated with an enhanced CD16-driven NK cell activation potential and behaves as a susceptibility factor identifying patients at higher risk to develop coronary artery disease of the transplanted heart. At the individual level, such a highly responsive NK cell profile associated with the VV genotype and CD16 expression levels is expected to shape the intensity of NK cell antibody-dependent cellular cytotoxic and inflammatory paracrine function through the release of CD107a/Lamp1 cytotoxic granules and inflammatory cytokines such as interferon (IFN)-γ.
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Obesity leads to higher risk of sperm DNA damage in infertile patients

Obesity leads to higher risk of sperm DNA damage in infertile patients

Over the past few years, there has been a growing interest on the link between male nutrition and infertility. It is important to evaluate the potential effect of overweight or obesity on DNA integrity, since lower pregnancy rates or higher miscarriage rates have been reported in cases of increased sperm DNA fragmentation. 13 Six studies have been pub- lished with conflicting results because of the heterogeneity of the techniques and the small samples used in some studies (Table 3). Kort et al. 3 reported an increased sperm DNA fragmentation rate,

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Impacts of climate change on tomato, a notorious pest and its natural enemy: small scale agriculture at higher risk

Impacts of climate change on tomato, a notorious pest and its natural enemy: small scale agriculture at higher risk

for a warmer world than the GCM/SERS used in the Figure 3. Change in area suitability for tomato cultivation between 1975H and 2050 (A1B—CSIRO MK.3). Data for areas equipped with AEI for 29 countries with more than 20000 ha of tomatoes in 2000 (FAOSTAT 2019 ), ranked from most to least affected. Area loss refers to areas suitable for tomato cultivation in 1975H (EI>30—suitability category medium or higher) and unsuitable-low suitability (EI „30) in 2050, while area gain refers to the opposite case. Worse/Better refers to a decrease/increase in area suitability, respectively. The black dashed line shows the average area of tomato cultivation (1998–2002) per country (FAOSTAT 2019 ).
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First-order (Conditional) Risk Aversion, Background Risk and Risk Diversification

First-order (Conditional) Risk Aversion, Background Risk and Risk Diversification

higher level of the background variable mitigates the detrimental effect of a reduction in wealth. This condition involves the expectation dependence between two risks and the cross derivative of the utility function. It captures the welfare interaction between the two risks. The sign of the first-degree expectation dependence indicates whether the movements on background risk tend to reinforce the movements on wealth (positive first-degree expectation dependence) or to counteract them (negative first-degree expectation dependence). Lemma (4.4) allows a quantitative treatment of the direction and size of first-degree expectation dependence effect on first order risk aversion. To clarify this, consider the following cases: (1) assume the agent is correlation neutral (u 12 = 0) or the background risk is independent (ED(y) = 0), then the
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Optimal risk sharing with background risk

Optimal risk sharing with background risk

A drawback of this analysis is that it assumes that markets are complete. As already mentioned by Doherty and Schlesinger (1983a,b), Schlesinger and Doherty (1985) and Gol- lier (1996), first insurers prefer to cover different sources of risk by different contracts and next, some risks such as war, floods, earthquakes, market risks, and human capital are not insurable. Hence, it seems necessary to reconsider insurance problems under the assumption of background risk. Furthermore, the problem of insurance in the presence of background risk arises in the pricing of climatic options (the risk to be insured is a climatic risk and the background risk is the financial risk, see for example Barrieu and El Karoui (2002, 2003)). It also arises when an insured faces a sequence of risks over time and chooses at each date an insurance contract that depends on the forthcoming risk and on her history.
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Homotopy theory of higher categories

Homotopy theory of higher categories

In 1980, Dwyer and Kan came out with their theory of simplicial lo- calization, allowing the association of a simplicial category to any pair (M , W ) and giving the higher categorical version of Gabriel-Zisman’s theory. They developped an extensive theory of simplicial categories, in- cluding several different constructions of the simplicial localization which inverts the morphisms of W in a homotopical sense. This construction provides the door passing from the world of categories to the world of higher categories, because even if we start with a regular 1-category, then localize by inverting a collection of morphisms, the simplicial lo- calization is in general a simplicial category which is not a 1-category. The simplicial localization maps to the usual or Gabriel-Zisman local- ization but the latter is only the 1-truncation. So, if we want to invert a collection of morphisms in a “homotopically correct” way, we are forced to introduce some kind of higher categorical structure, at the very least the notion of simplicial category. Unfortunately, the importance of the Dwyer-Kan construction doesn’t seem to have been generally noticed at the time.
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Polynomial interpolation in higher dimensions

Polynomial interpolation in higher dimensions

Abstract We describe a recent advance in the theory of interpolation in the plane, based on the theory of line arrangements in the complex projective plane?. 1 Interpolation in dimension[r]

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Contributions to higher recursion theory

Contributions to higher recursion theory

Sacks and the author have constructed in E(wi) forcing which peserves E-closure while destroying the stationarity of some subset of w 1: this forcing is an example of so[r]

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On Sharing Risk in Large Economies: Risk and Risk Aversion

On Sharing Risk in Large Economies: Risk and Risk Aversion

The Arrow-Lind argument has been carried over to the private financial sector in an analogous way. It is argued that, with a very large number of investors, risk spreading implies that the risk premium goes to zero and thus eliminates any exposure to, and concern for risk. In other words, while the shareholders are risk-averse, there is no need to account for their risk aversion for large economies and they act as if they are risk-neutral. 1 Hence, only the expected payoff of a risky asset must be considered for trading decisions, which is then reflected in the market price.
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Tiered complexity at higher order

Tiered complexity at higher order

ar(op) → W be the function computed by the operator. 3 A tier-based type system We introduce a type system with k tiers (a tier can be viewed as a natural number) inspired by the type system of [3] that prevents data flows from lower tiers to higher tiers. Types are tuples of 3 tiers.

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From planar graphs to higher dimension

From planar graphs to higher dimension

Abstract. In this thesis, we look for generalizations of some properties of planar graphs to higher dimensions by replacing graphs by simplicial complexes. In particular we study the Dushnik-Miller dimension which measures how a partial order is far from being a linear order. When applied to simplicial complexes, this dimension seems to capture some geometric properties. In this idea, we disprove a conjecture asserting that any simplicial complex of Dushnik- Miller dimension at most d + 1 can be represented as a TD-Delaunay complex in R d , which is a variant of the well known Delaunay graphs in the plane. We show that any supremum section, particular simplicial complexes related to the Dushnik-Miller dimension, is collapsible, which means that it is possible to reach the single point by removing in a certain order the faces of the complex. We introduce the notion of stair packings and we prove that the Dushnik-Miller dimension is connected to contact complexes of such packings.
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Bisimulation for higher-order process calculi

Bisimulation for higher-order process calculi

Unite´ de recherche INRIA Lorraine, Technopoˆle de Nancy-Brabois, Campus scientifique, 615 rue du Jardin Botanique, BP 101, 54600 VILLERS LE`S NANCY Unite´ de recherche INRIA Rennes, Iri[r]

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Higher-­Level, Downward and Specific Causation

Higher-­Level, Downward and Specific Causation

The  modified  interventionist  framework  we  have  sketched  makes  it  possible  to   justify  the  claim  that  statements  of  higher-­‐level  and  downward  causation  are  empirically   significant.  The  content  of  such  statements,  spelled  out  in  terms  of  interventionist   criteria,  differs  from  the  content  of  the  corresponding  lower-­‐level  causal  statements.  The   empirical  truth-­‐conditions  of  a  downward  causal  statement  according  to  which  a  higher   level  variable  M  influences  a  lower-­‐level  variable  E  differ  from  the  truth-­‐conditions  of   the  statement  that  a  variable  P,  which  characterizes  M’s  supervenience  base,  influences   E.  The  absence  of  higher-­‐level  and  downward  causation  can  sometimes  be  justified  only   inductively  but  this  epistemic  problem  is  no  reason  to  deny  that  the  truth  conditions  of   such  statements  differ  from  those  of  the  underlying  lower-­‐level  statements.    
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Higher Order Unification via Explicit Substitutions

Higher Order Unification via Explicit Substitutions

Unité de recherche INRIA Lorraine, Technopôle de Nancy-Brabois, Campus scientifique, 615 rue du Jardin Botanique, BP 101, 54600 VILLERS LÈS NANCY Unité de recherche INRIA Rennes, Irisa, [r]

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Refinement Types as Higher Order Dependency Pairs

Refinement Types as Higher Order Dependency Pairs

component, the decrease condition holds, then every well-typed term is strongly normalizing under the rewrite rules and β-reduction. The actual operational se- mantics are defined not on the terms themselves, but on erased terms in which we remove the explicit type information. We then conclude with a comparison with other approaches to higher-order dependency pairs and possible extensions of our criterion.

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Higher education systems and industrial innovation

Higher education systems and industrial innovation

Hybrid worlds This model contrasts with another way of apprehending the links between academia and industry. This approach now unites many researchers in the social sciences who take the view that there are analogies between the academic world and industry. Markets and hierarchies, it is said, inform both systems, their objectives are compatible and often complementary and occupational identities in the two systems are closely related. It is therefore possible to establish networks of productive relationships between the two, linked either to the construction of competences or to that of knowledge and expertise. These networks are both a vehicle for information flows and the means by which the resources of all those involved in innovation are coordinated (Knorr-Cetina 1982; Laredo, Callon and Mustar, 1992). By controlling relations and creating trust between the partners, these research contracts make it possible to extend economic organisation beyond the firm (Cassier 1995, 1997, Estades 1995). Thus Aoki (1988) notes that the increasing co-operation on R&D both between firms and between firms and the higher education and research system in Japan may indicate that a new form of industrial organisation is emerging. This model emphasises the strength of the interactions between the initial socialisation and the construction of competences in firms. From this perspective, it is no longer relevant to think in terms of a clear distinction between the basic research carried out in academic institutions and the applied research carried out in firms. Any analysis must be holistic, taking account of the dynamic of the innovation cycle, the type of product that can be a vehicle for innovation, the competences, knowledge and expertise deployed and the various legitimation and incentive systems mobilised in the innovation process. Some of these processes may, through a multiplicity of feedback loops, bring into play different functions within research organisations and firms (Kline and Rosenberg's chain-link model, see Kline and Rosenberg 1986 in Gaffard 1990). From this point of view, there are "grey zones in
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